DE602007013365D1 - Mikrofluidische Vorrichtung und Verfahren für Reaktionen nicht mischbarer Flüssigkeiten - Google Patents

Mikrofluidische Vorrichtung und Verfahren für Reaktionen nicht mischbarer Flüssigkeiten

Info

Publication number
DE602007013365D1
DE602007013365D1 DE602007013365T DE602007013365T DE602007013365D1 DE 602007013365 D1 DE602007013365 D1 DE 602007013365D1 DE 602007013365 T DE602007013365 T DE 602007013365T DE 602007013365 T DE602007013365 T DE 602007013365T DE 602007013365 D1 DE602007013365 D1 DE 602007013365D1
Authority
DE
Germany
Prior art keywords
chamber
channels
width
microfluidic device
reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007013365T
Other languages
English (en)
Inventor
Berengere Chevalier
Clemens Horn
Maxime Moreno
Pierre Woehl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Inc
Original Assignee
Corning Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Inc filed Critical Corning Inc
Publication of DE602007013365D1 publication Critical patent/DE602007013365D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/421—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/00862—Dimensions of the reaction cavity itself
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/0093—Electric or magnetic energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00932—Sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00934—Electromagnetic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00975—Ultraviolet light

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
DE602007013365T 2007-05-15 2007-07-11 Mikrofluidische Vorrichtung und Verfahren für Reaktionen nicht mischbarer Flüssigkeiten Active DE602007013365D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07301042A EP1992403B1 (de) 2007-05-15 2007-05-15 Mikrofluidische und selbstverzögernde oszillierende Mischer sowie Vorrichtungen und Verfahren zu deren Verwendung

Publications (1)

Publication Number Publication Date
DE602007013365D1 true DE602007013365D1 (de) 2011-05-05

Family

ID=38537743

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602007013010T Active DE602007013010D1 (de) 2007-05-15 2007-05-15 Mikrofluidische und selbstverzögernde oszillierende Mischer sowie Vorrichtungen und Verfahren zu deren Verwendung
DE602007013365T Active DE602007013365D1 (de) 2007-05-15 2007-07-11 Mikrofluidische Vorrichtung und Verfahren für Reaktionen nicht mischbarer Flüssigkeiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE602007013010T Active DE602007013010D1 (de) 2007-05-15 2007-05-15 Mikrofluidische und selbstverzögernde oszillierende Mischer sowie Vorrichtungen und Verfahren zu deren Verwendung

Country Status (9)

Country Link
US (1) US20100182868A1 (de)
EP (1) EP1992403B1 (de)
JP (1) JP2011504221A (de)
KR (1) KR20100017806A (de)
CN (1) CN101678293B (de)
AT (2) ATE500884T1 (de)
DE (2) DE602007013010D1 (de)
TW (1) TW200946217A (de)
WO (1) WO2008143923A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2955508B1 (fr) * 2010-01-25 2012-03-30 Corning Inc Microreacteurs avec dispositif microfluidique plan et systeme d'application d'ultrasons ; mise en oeuvre de reactions chimiques en leur sein
US8475738B2 (en) * 2010-05-04 2013-07-02 Electronics And Telecommunications Research Institute Photocatalytic apparatus and method for injecting microfluidic volumes
WO2012133394A1 (ja) * 2011-03-28 2012-10-04 学校法人加計学園 試料溶液濃度測定方法及び試料溶液濃度測定装置
US9138714B2 (en) 2011-10-31 2015-09-22 General Electric Company Microfluidic chip and a related method thereof
TWI426951B (zh) * 2011-11-07 2014-02-21 Univ Nat Pingtung Sci & Tech 流體混合裝置
WO2017175207A1 (en) * 2016-04-08 2017-10-12 Universidade Do Minho Modular oscillatory flow plate reactor
CA3063989A1 (en) * 2017-05-30 2018-12-06 Glaxosmithkline Biologicals Sa Methods for manufacturing a liposome encapsulated rna
CN108636308A (zh) * 2018-05-02 2018-10-12 侯建华 一种管式通用型氯化微反应器
BE1026312B1 (nl) * 2018-05-25 2019-12-23 Ajinomoto Omnichem Doorstroomreactor en gebruik ervan
WO2020115178A2 (en) 2018-12-06 2020-06-11 Glaxosmithkline Biologicals Sa Microfluidic devices
CN109531851B (zh) * 2019-01-16 2023-08-01 浙江富士特硅橡胶材料有限公司 一种婴童用品用加成型液体硅橡胶混料装置
CN113019212B (zh) * 2019-12-23 2023-08-25 胡桃夹子治疗公司 微流体装置及其使用方法
CN111939856B (zh) * 2020-07-02 2022-12-30 山东豪迈机械制造有限公司 一种振动反应器及板式反应器
CN114471217A (zh) * 2022-04-02 2022-05-13 深圳市瑞吉生物科技有限公司 一种用于脂质体合成的对冲流混合装置及方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926373A (en) * 1974-07-26 1975-12-16 Us Air Force Thrust augmentation system with oscillating jet nozzles
JP3906324B2 (ja) 2001-09-10 2007-04-18 インターナショナル・ビジネス・マシーンズ・コーポレーション 自動化されたデータ・ストレージ・ライブラリにおけるデータ・ストレージ・ドライブを割り振るための割振りシステム、方法及びコンピュータ可読プログラム
SE0103110D0 (sv) * 2001-09-18 2001-09-18 Aamic Ab Microscale fluid handling system
FR2830206B1 (fr) 2001-09-28 2004-07-23 Corning Inc Dispositif microfluidique et sa fabrication
WO2004076056A2 (en) * 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US7435391B2 (en) * 2003-05-23 2008-10-14 Lucent Technologies Inc. Light-mediated micro-chemical reactors
EP1944079B1 (de) 2004-06-11 2012-05-30 Corning Incorporated Mikrostrukturentwürfe zur Optimierung von Mischen und Druckverlust
CN100427194C (zh) * 2004-08-27 2008-10-22 中国科学院长春光学精密机械与物理研究所 芯片内微流体动态混合器、混合池模具及其驱动方法
KR100634525B1 (ko) * 2004-11-23 2006-10-16 삼성전자주식회사 복수 개의 전자석이 배치되어 있는 마이크로채널을포함하는 미세유동 장치, 그를 이용하여 시료를 혼합하는방법 및 세포를 용해하는 방법
EP1679115A1 (de) 2005-01-07 2006-07-12 Corning Incorporated Hochleistungsmikroreaktor
DE602007008355D1 (de) 2007-02-28 2010-09-23 Corning Inc Verfahren zur Herstellung von mikrofluidischen Vorrichtungen

Also Published As

Publication number Publication date
TW200946217A (en) 2009-11-16
JP2011504221A (ja) 2011-02-03
ATE502692T1 (de) 2011-04-15
DE602007013010D1 (de) 2011-04-21
CN101678293B (zh) 2012-11-07
KR20100017806A (ko) 2010-02-16
WO2008143923A1 (en) 2008-11-27
EP1992403A1 (de) 2008-11-19
EP1992403B1 (de) 2011-03-09
ATE500884T1 (de) 2011-03-15
CN101678293A (zh) 2010-03-24
US20100182868A1 (en) 2010-07-22

Similar Documents

Publication Publication Date Title
DE602007013365D1 (de) Mikrofluidische Vorrichtung und Verfahren für Reaktionen nicht mischbarer Flüssigkeiten
ATE413921T1 (de) Mikrofluidische vorrichtung enthaltend eine blasenfalle
DE602007011745D1 (de) Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung
ATE530250T1 (de) Mikrofluidische vorrichtung und verfahren zur verdünnung von flüssigkeit in spuren
Wang et al. Mixing enhancement of novel passive microfluidic mixers with cylindrical grooves
WO2009069608A1 (ja) マイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法
EP1894619A3 (de) Mikrokanalstruktur und Verfahren zur Feinteilchenherstellung damit
MXPA06012259A (es) Dispositivo y metodo para crear cavitacion de vortice en fluidos.
HK1127091A1 (en) Droplet-based pyrosequencing
ATE409077T1 (de) Verfahren zur mehrfachreaktion in einem mikroreaktor und mikroreaktor
US7585462B2 (en) Biochip with microchannels
ATE392947T1 (de) Mischen in mikrofluidvorrichtungen
ATE375199T1 (de) Vorrichtung zur mischung von fluiden
DE602005007154D1 (de) Mikrofluidische Vorrichtung mit einem Mikrokanal mit mehreren Elektromagneten, und Verfahren zur Mischung von Proben und zur Zellyse durch die Verwendung der mikrofluidischen Vorrichtung
ATE547694T1 (de) Vorrichtung zum mischen von flüssigkeiten und darauf bezogenes verfahren
DE502005003443D1 (de) Statischer Mikrovermischer
MX2013012365A (es) Sistema microfluidico para control de la concentracion de moleculas para la estimulacion de un objetivo.
EP1908514A3 (de) Mikroreaktor
ATE399054T1 (de) Probenmischen auf einer mikrofluidischen vorrichtung und verfahren
ATE392251T1 (de) Vorrichtung zum dispergieren eines festen, flüssigen oder gasförmigen stoffes in einer flüssigkeit
ATE273744T1 (de) Mikrokanalvorrichtung und verfahren
Sarma et al. Design and analysis of passive Y-type micromixers for enhanced mixing performance for biomedical and microreactor application
ATE405339T1 (de) Fluidisches misch- und reaktionsverfahren mit verwendung einer mikrovorrichtung, und mikrovorrichtung
ATE337534T1 (de) Verfahren zur gewinnung einer gasförmigen phase aus einem flüssigen medium und vorrichtung zu seiner durchführung
EP1724007A3 (de) Mischvorrichtung für Fluide unter Verwendung von Querkanälen