DE602007007757D1 - Proliferationshemmende verbindungen aus einem 3-aryl-coumarin oder einem 3-aryl-chinolin-2-on und anwendungen davon - Google Patents

Proliferationshemmende verbindungen aus einem 3-aryl-coumarin oder einem 3-aryl-chinolin-2-on und anwendungen davon

Info

Publication number
DE602007007757D1
DE602007007757D1 DE602007007757T DE602007007757T DE602007007757D1 DE 602007007757 D1 DE602007007757 D1 DE 602007007757D1 DE 602007007757 T DE602007007757 T DE 602007007757T DE 602007007757 T DE602007007757 T DE 602007007757T DE 602007007757 D1 DE602007007757 D1 DE 602007007757D1
Authority
DE
Germany
Prior art keywords
aryl
coumarine
proliferation
chinolin
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007007757T
Other languages
English (en)
Inventor
Matthieu Schapira
Cyrile Lamigeon
Mathieu Gutmann
Audrey Barthelaix
Nicolas Hugo
Pierre Colas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clovis Oncology Italy SRL
Original Assignee
EOS Ethical Oncology Science SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EOS Ethical Oncology Science SpA filed Critical EOS Ethical Oncology Science SpA
Publication of DE602007007757D1 publication Critical patent/DE602007007757D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE602007007757T 2006-05-22 2007-05-22 Proliferationshemmende verbindungen aus einem 3-aryl-coumarin oder einem 3-aryl-chinolin-2-on und anwendungen davon Active DE602007007757D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06290821A EP1860104A1 (de) 2006-05-22 2006-05-22 Von 3-Arylcoumarin oder 3-Arylchinolin-2-on abgeleitete antiproliferative Verbindungen und ihre Verwendung
PCT/IB2007/002179 WO2007135565A2 (en) 2006-05-22 2007-05-22 Anti-proliferative compounds deriving from a 3-aryl-coumarine or 3-aryl-quinolin-2-one and uses thereof

Publications (1)

Publication Number Publication Date
DE602007007757D1 true DE602007007757D1 (de) 2010-08-26

Family

ID=37075181

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007007757T Active DE602007007757D1 (de) 2006-05-22 2007-05-22 Proliferationshemmende verbindungen aus einem 3-aryl-coumarin oder einem 3-aryl-chinolin-2-on und anwendungen davon

Country Status (7)

Country Link
US (1) US20090203685A1 (de)
EP (2) EP1860104A1 (de)
JP (1) JP2009538290A (de)
CN (1) CN101448811A (de)
AT (1) ATE473969T1 (de)
DE (1) DE602007007757D1 (de)
WO (1) WO2007135565A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115403549B (zh) * 2022-08-30 2023-05-26 郑州大学 蛇床子素硫脲类衍生物、及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2781218B1 (fr) * 1998-07-15 2001-09-07 Lafon Labor Compositions pharmaceutiques comprenant des 2-quinolones
DE69910830T2 (de) * 1998-12-30 2004-06-17 Signal Pharmaceutical, Inc., San Diego Verbindungen und verfahren zur modulation von estrogen rezeptoren
AU2002334355A1 (en) * 2001-09-06 2003-03-18 Prochon Biotech Ltd. Protein tyrosine kinase inhibitors
CA2514244A1 (en) * 2003-02-11 2004-08-26 Warner-Lambert Company Llc Benzyl urea and thiourea derivatives useful as androgen antagonists

Also Published As

Publication number Publication date
EP1860104A1 (de) 2007-11-28
WO2007135565A3 (en) 2008-04-03
CN101448811A (zh) 2009-06-03
WO2007135565A2 (en) 2007-11-29
ATE473969T1 (de) 2010-07-15
EP2021333B1 (de) 2010-07-14
US20090203685A1 (en) 2009-08-13
EP2021333A2 (de) 2009-02-11
JP2009538290A (ja) 2009-11-05

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