DE602006018746D1 - Ply-gbs-lysinmutanten - Google Patents

Ply-gbs-lysinmutanten

Info

Publication number
DE602006018746D1
DE602006018746D1 DE602006018746T DE602006018746T DE602006018746D1 DE 602006018746 D1 DE602006018746 D1 DE 602006018746D1 DE 602006018746 T DE602006018746 T DE 602006018746T DE 602006018746 T DE602006018746 T DE 602006018746T DE 602006018746 D1 DE602006018746 D1 DE 602006018746D1
Authority
DE
Germany
Prior art keywords
gbs
plygbs
streptococci
lysins
bacteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006018746T
Other languages
English (en)
Inventor
Vincent A Fischetti
Qi Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of DE602006018746D1 publication Critical patent/DE602006018746D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602006018746T 2005-08-24 2006-08-17 Ply-gbs-lysinmutanten Active DE602006018746D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71093605P 2005-08-24 2005-08-24
PCT/US2006/032176 WO2007024628A2 (en) 2005-08-24 2006-08-17 Ply-gbs mutant lysins

Publications (1)

Publication Number Publication Date
DE602006018746D1 true DE602006018746D1 (de) 2011-01-20

Family

ID=37772174

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006018746T Active DE602006018746D1 (de) 2005-08-24 2006-08-17 Ply-gbs-lysinmutanten

Country Status (9)

Country Link
US (1) US8105585B2 (de)
EP (2) EP2360248A1 (de)
JP (1) JP2009506033A (de)
CN (1) CN101297034A (de)
AT (1) ATE491026T1 (de)
CA (1) CA2620903A1 (de)
DE (1) DE602006018746D1 (de)
ES (1) ES2357626T3 (de)
WO (1) WO2007024628A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008018854A2 (en) * 2005-06-06 2008-02-14 The Rockefeller University Bactiophage lysins for bacillus anthracis
ATE491026T1 (de) 2005-08-24 2010-12-15 Univ Rockefeller Ply-gbs-lysinmutanten
WO2010002959A2 (en) * 2008-07-03 2010-01-07 The Rockefeller University A chimeric bacteriophage lysin with activity against staphylococci bacteria
US9034322B2 (en) 2011-04-21 2015-05-19 The Rockefeller University Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
CN108424464A (zh) 2011-10-05 2018-08-21 洛克菲勒大学 二聚噬菌体溶素
CN102516398B (zh) * 2011-12-27 2014-07-16 中国科学院遗传与发育生物学研究所 抗乳房炎转基因小鼠模型的构建方法及其专用载体
IL235527B2 (en) 2012-05-09 2023-10-01 Contrafect Corp Combinations of bacteriophage lysine and antibiotics against gram-positive bacteria
US9499594B2 (en) 2012-05-09 2016-11-22 Contrafect Corporation Biofilm prevention, disruption and treatment with bacteriophage lysin
DE102013106455A1 (de) 2013-06-20 2014-12-24 Airbus Defence and Space GmbH Verfahren zur Dekontamination von bakteriologischen Verunreinigungen
DK3454888T3 (da) 2016-05-12 2021-04-26 Contrafect Corp Bouillon-mikrofortyndingsfremgangsmåde til evaluering og bestemmelse af minimal inhibitorisk koncentration for antibakterielle polypeptider
CN107083434B (zh) * 2017-06-05 2020-09-08 武汉赛思锐微生物技术有限公司 一种非诊断目的的荧光pcr定量检测b族链球菌的样本前处理方法
WO2018231089A1 (ru) * 2017-06-16 2018-12-20 Борис Славинович ФАРБЕР Биологически активные комбинаторные производные полисахаридов
EP3771463A1 (de) * 2019-07-29 2021-02-03 Ludwig-Maximilians-Universität München Stabilisierung therapeutischer proteine mit piperazin- oder morpholinhaltigen zwitterionischen puffersubstanzen
CN112501189A (zh) * 2020-12-30 2021-03-16 吉林大学 一种能杀死马链球菌马亚种的裂解酶及其医用用途
KR20240015756A (ko) * 2022-07-26 2024-02-06 주식회사 인트론바이오테크놀로지 젖소유방염 치료용 항균단백질 조성물

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
EP0501523B1 (de) 1983-11-14 1997-04-09 Columbia Laboratories, Inc. Bioadhäsive Mittel
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
DE229046T1 (de) 1985-03-30 1987-12-17 Marc Genf/Geneve Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4680338A (en) 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
JPS63502716A (ja) 1986-03-07 1988-10-13 マサチューセッツ・インステチュート・オブ・テクノロジー 糖タンパク安定性の強化方法
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4948580A (en) 1988-12-08 1990-08-14 E. R. Squibb & Sons, Inc. Muco-bioadhesive composition
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
JPH02258718A (ja) 1989-03-31 1990-10-19 Nippon Kayaku Co Ltd ペースト状基剤及び製剤
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
DE69329295T2 (de) 1992-12-02 2001-03-15 Alkermes Controlled Therapeutics, Inc. Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5554380A (en) 1994-08-04 1996-09-10 Kv Pharmaceutical Company Bioadhesive pharmaceutical delivery system
PT779806E (pt) 1994-09-09 2001-02-28 Takeda Chemical Industries Ltd Preparacao de libertacao sustentada contendo um sal metalico de um peptido
AU708756B2 (en) 1995-06-07 1999-08-12 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of human growth hormone
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
US5942243A (en) 1996-11-12 1999-08-24 Polytherapeutics, Inc. Mucoadhesive compositions for administration of biologically active agents to animal tissue
US6056954A (en) 1997-10-31 2000-05-02 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6056955A (en) 1999-09-14 2000-05-02 Fischetti; Vincent Topical treatment of streptococcal infections
AU2003291614A1 (en) 2002-05-17 2004-04-08 New Horizons Diagnostics Corporation Identification of a phage associated lytic enzyme to rapidly and specifically detect and kill bacillus anthracis
WO2004020451A1 (en) * 2002-08-29 2004-03-11 The Uab Research Foundation Group b streptococcal phage lysin
US7569223B2 (en) 2004-03-22 2009-08-04 The Rockefeller University Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions
EP1744779A2 (de) 2004-03-24 2007-01-24 The Rockfeller University Lytische enzyme und sporen-oberflächenantigen zum nachweis und zur behandlung von bacillus anthracis bakterien und sporen
US7582291B2 (en) 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
ATE491026T1 (de) 2005-08-24 2010-12-15 Univ Rockefeller Ply-gbs-lysinmutanten
WO2010002959A2 (en) 2008-07-03 2010-01-07 The Rockefeller University A chimeric bacteriophage lysin with activity against staphylococci bacteria

Also Published As

Publication number Publication date
ES2357626T3 (es) 2011-04-28
JP2009506033A (ja) 2009-02-12
EP1917355A2 (de) 2008-05-07
US20080221035A1 (en) 2008-09-11
CN101297034A (zh) 2008-10-29
EP2360248A1 (de) 2011-08-24
EP1917355B1 (de) 2010-12-08
WO2007024628A3 (en) 2007-06-14
WO2007024628A2 (en) 2007-03-01
CA2620903A1 (en) 2007-03-01
ATE491026T1 (de) 2010-12-15
US8105585B2 (en) 2012-01-31
EP1917355A4 (de) 2009-05-27

Similar Documents

Publication Publication Date Title
DE602006018746D1 (de) Ply-gbs-lysinmutanten
DE602005012276D1 (de) Verwendung von probiotischen bakterien zur herstellung von topischen zusammensetzungen zum schutz der haut
TW200507841A (en) Antibacterial agents
DE60334016D1 (de) Antibakterielle mittel
ATE347277T1 (de) Zusammensetzung mit bakteriostatischen und bakteriziden eigenschaften gegen bakterielle sporen und zellen und verfahren zu deren verwendung zur behandlung von lebensmitteln
WO2005072826A3 (en) Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection
TW200621256A (en) Formulations
UA93384C2 (ru) Способ получения стерилизированного порошкообразного панкреатина
WO2006084210A3 (en) Hif modulating compounds and methods of use thereof
ATE484509T1 (de) Antibakterielle mittel
WO2006081182A3 (en) Antibacterial agents
WO2006081178A3 (en) Antibacterial agents
ATE461928T1 (de) Antibakterielle wirkstoffe
ATE549023T1 (de) Formulierungen mit jorumycin-, renieramycin-, safracin- oder saframycin-verwandten verbindungen und einen disaccharide zur behandlung von proliferativen erkrankungen
HK1106253A1 (en) Desoxo-nonadepsipeptides
NO20072890L (no) Behandling av mastitt
ATE455789T1 (de) Substituierte nonadepsipeptide
EA200400197A1 (ru) Способы получения поливалентных бактериофагов для лечения бактериальных инфекций
ATE410443T1 (de) Heterocyclyl-substituierte nonadepsipeptide
IL194353A0 (en) Lysobactin amides
TNSN06453A1 (en) Treatment of bacterial infections
WO2005042699A3 (en) Modified polypeptides with therapeutic activity and methods of use
WO2005086669A3 (en) Hydrogenase deficient bacterial strains
DE602006016724D1 (de) Methode zur herstellung von gluten-freien kulturen der gattung penicillium und deren verwendung in blauschimmelmilchprodukten
ATE418613T1 (de) Antimikrobielle zusammensetzungen