DE602006018152D1 - Triazolderivate als modulatoren von dopamin-d3-rezeptoren - Google Patents
Triazolderivate als modulatoren von dopamin-d3-rezeptorenInfo
- Publication number
- DE602006018152D1 DE602006018152D1 DE602006018152T DE602006018152T DE602006018152D1 DE 602006018152 D1 DE602006018152 D1 DE 602006018152D1 DE 602006018152 T DE602006018152 T DE 602006018152T DE 602006018152 T DE602006018152 T DE 602006018152T DE 602006018152 D1 DE602006018152 D1 DE 602006018152D1
- Authority
- DE
- Germany
- Prior art keywords
- 4alkyl
- group
- haloc1
- 4alkoxy
- 4alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0517202A GB0517202D0 (en) | 2005-08-22 | 2005-08-22 | Compounds |
GB0517181A GB0517181D0 (en) | 2005-08-22 | 2005-08-22 | Compounds |
PCT/EP2006/008200 WO2007022933A1 (en) | 2005-08-22 | 2006-08-18 | Triazole derivatives as modulators of dopamine d3 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006018152D1 true DE602006018152D1 (de) | 2010-12-23 |
Family
ID=37309176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006018152T Active DE602006018152D1 (de) | 2005-08-22 | 2006-08-18 | Triazolderivate als modulatoren von dopamin-d3-rezeptoren |
Country Status (6)
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1745040T1 (sl) * | 2004-02-23 | 2010-04-30 | Venue Glaxo Group Ltd | Derivati azabiciklo(3.1.0)heksana, uporabni kot modulatorji dopaminskih receptorjev d3 |
US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
GB0507601D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
GB0507602D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
EP1891056B1 (en) * | 2005-06-14 | 2010-10-13 | Glaxo Group Limited | Novel compounds |
EP2719384B1 (en) | 2005-07-27 | 2018-08-08 | Otsuka America Pharmaceutical, Inc. | Novel 1-naphthyl-3-azabicyclo[3.1.0]hexanes:preparation and use to treat neuropsychiatric disorders |
GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
GB0517187D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
GB0517193D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
GB0517175D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
US8222266B2 (en) * | 2006-04-03 | 2012-07-17 | Glaxo Group Limited | Azabicyclo [3.1.0] hexyl derivatives as modulators of dopamine D3 receptors |
US8163927B2 (en) * | 2006-04-03 | 2012-04-24 | Glaxo Group Limited | Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors |
US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
EP2167083B1 (en) * | 2007-06-06 | 2015-10-28 | Euthymics Bioscience, Inc. | 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
WO2010150281A2 (en) | 2009-06-26 | 2010-12-29 | Panacea Biotec Ltd. | Novel azabicyclohexanes |
US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
CN113956157B (zh) * | 2021-11-18 | 2024-05-03 | 西安都创医药科技有限公司 | 一种合成2-甲酰基-1-环丙烷甲酸乙酯的方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
AR022228A1 (es) | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion |
DE60305519T2 (de) * | 2002-10-07 | 2006-11-23 | Glaxo Group Ltd., Greenford | Sulfonamidderivate als antipsychotische mittel |
DE10304870A1 (de) * | 2003-02-06 | 2004-08-19 | Abbott Gmbh & Co. Kg | Triazolverbindungen und ihre therapeutische Verwendung |
SI1745040T1 (sl) | 2004-02-23 | 2010-04-30 | Venue Glaxo Group Ltd | Derivati azabiciklo(3.1.0)heksana, uporabni kot modulatorji dopaminskih receptorjev d3 |
GB0507602D0 (en) | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
GB0507601D0 (en) | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
EP1891056B1 (en) | 2005-06-14 | 2010-10-13 | Glaxo Group Limited | Novel compounds |
GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
GB0517187D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
GB0517193D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
GB0517175D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
PE20071152A1 (es) | 2006-04-03 | 2007-12-16 | Glaxo Group Ltd | Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3 |
GB0616574D0 (en) | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
-
2006
- 2006-08-18 US US12/064,128 patent/US7799815B2/en not_active Expired - Fee Related
- 2006-08-18 EP EP06776990A patent/EP1919908B1/en active Active
- 2006-08-18 JP JP2008527370A patent/JP5237807B2/ja not_active Expired - Fee Related
- 2006-08-18 WO PCT/EP2006/008200 patent/WO2007022933A1/en active Application Filing
- 2006-08-18 AT AT06776990T patent/ATE487715T1/de not_active IP Right Cessation
- 2006-08-18 DE DE602006018152T patent/DE602006018152D1/de active Active
Also Published As
Publication number | Publication date |
---|---|
US20090221593A1 (en) | 2009-09-03 |
EP1919908B1 (en) | 2010-11-10 |
JP2009504791A (ja) | 2009-02-05 |
EP1919908A1 (en) | 2008-05-14 |
JP5237807B2 (ja) | 2013-07-17 |
WO2007022933A1 (en) | 2007-03-01 |
ATE487715T1 (de) | 2010-11-15 |
US7799815B2 (en) | 2010-09-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602006018152D1 (de) | Triazolderivate als modulatoren von dopamin-d3-rezeptoren | |
ATE493404T1 (de) | Azabicyclo-(3,1,0)-hexan-derivate als modulatoren von dopamin-d3-rezeptoren | |
DE602006006850D1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate | |
NO20064309L (no) | Azabicyklo(3.1.0)heksanderivater anvendelige som modulatorer for dopamin D3 receptorer | |
ATE484502T1 (de) | Neue verbindungen | |
PE20070212A1 (es) | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen | |
GB0507601D0 (en) | Compounds | |
PE20061436A1 (es) | Derivados de amida sustituida como inhibidores de proteina quinasa | |
PE20110028A1 (es) | Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato | |
BR122012009489B8 (pt) | processo para produzir 2-etóxi-1-{[2-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso | |
PE20090188A1 (es) | Compuestos heterociclicos como moduladores de la senda de hedgehog | |
AR077935A1 (es) | Derivados de 3-amino-5 fenil-5,6-dihidro-2h-(1,4)oxazina | |
PE20090370A1 (es) | Derivados de heterociclo fusionado como inhibidores de quinasa | |
EA201101566A1 (ru) | Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ | |
EA200500304A1 (ru) | Производные 3-(сульфонамидоэтил)индола, предназначенные для использования в качестве миметиков глюкокортикоидов при лечении воспалительных, аллергических и пролиферативных заболеваний | |
WO2006078621A3 (en) | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders | |
MX2007007103A (es) | Derivados espiro como inhibidores de lipoxigenasa. | |
ECSP088253A (es) | Derivados de azol y tiazol y sus usos | |
PE20110995A1 (es) | DERIVADOS DE PIRROLO[3,4-e]PIRIMIDINA COMO INHIBIDORES DE PDE1 | |
PE20080925A1 (es) | DERIVADOS DE PIRROLO[2,3-b]PIRIDINA COMO INHIBIDORES DE QUINASA, EN PARTICULAR INHIBIDORES IKK2 (O IKK BETA) | |
NO20080456L (no) | Nye 2,4-dianilinopyrimidinderivater, fremstilling derav og deres anvendelse som medikamenter, farmasoytiske sammensetninger og, spesielt, som IKK inhibitorer | |
TW200716531A (en) | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia | |
AR050617A1 (es) | Derivados de pirimidin sulfonamidas como moduladores de receptores de quimioquinas | |
PE20091436A1 (es) | Derivados de sulfonamidas sustituidas como moduladores b1r | |
CY1112679T1 (el) | Κινολινες και θεραπευτικη χρηση αυτων |