DE602006017217D1 - Stereoselektives hydrierverfahren zur herstellung von cis-6-phenyl-5-ä4-(2-pyrrolidin-1-yl-ethoxy)-phenylü-2-methoxy-5,6,7,8-tetrahydronaphthalin-hydrochlorid - Google Patents
Stereoselektives hydrierverfahren zur herstellung von cis-6-phenyl-5-ä4-(2-pyrrolidin-1-yl-ethoxy)-phenylü-2-methoxy-5,6,7,8-tetrahydronaphthalin-hydrochloridInfo
- Publication number
- DE602006017217D1 DE602006017217D1 DE602006017217T DE602006017217T DE602006017217D1 DE 602006017217 D1 DE602006017217 D1 DE 602006017217D1 DE 602006017217 T DE602006017217 T DE 602006017217T DE 602006017217 T DE602006017217 T DE 602006017217T DE 602006017217 D1 DE602006017217 D1 DE 602006017217D1
- Authority
- DE
- Germany
- Prior art keywords
- phenyl
- pyrrolidin
- ethoxy
- cis
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69288205P | 2005-06-22 | 2005-06-22 | |
| PCT/IB2006/001773 WO2006136944A1 (en) | 2005-06-22 | 2006-06-12 | Stereoselective hydrogenation process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006017217D1 true DE602006017217D1 (de) | 2010-11-11 |
Family
ID=37057316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006017217T Active DE602006017217D1 (de) | 2005-06-22 | 2006-06-12 | Stereoselektives hydrierverfahren zur herstellung von cis-6-phenyl-5-ä4-(2-pyrrolidin-1-yl-ethoxy)-phenylü-2-methoxy-5,6,7,8-tetrahydronaphthalin-hydrochlorid |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100160648A1 (de) |
| EP (1) | EP1899310B1 (de) |
| JP (1) | JP2009501143A (de) |
| AT (1) | ATE482940T1 (de) |
| CA (1) | CA2611035C (de) |
| DE (1) | DE602006017217D1 (de) |
| ES (1) | ES2350853T3 (de) |
| WO (1) | WO2006136944A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011146610A2 (en) * | 2010-05-19 | 2011-11-24 | Dr. Reddy's Laboratories Ltd. | An enantioselective synthesis of chiral amines for the production of rotigotine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3522319A (en) * | 1964-01-23 | 1970-07-28 | Ciba Geigy Corp | Phenol substituted tetrahydronaphthalenes useful as estrogenics |
| US5117013A (en) * | 1990-05-03 | 1992-05-26 | Eastman Kodak Company | Process for the selective hydrogenation γ, δ-epoxyalkenes to epoxyalkanes |
| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| UA51676C2 (uk) * | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція |
| EE200200580A (et) * | 2000-04-07 | 2004-06-15 | Pfizer Products Inc. | Östrogeeni agonisti/antagonisti metaboliidid |
-
2006
- 2006-06-12 EP EP06779787A patent/EP1899310B1/de not_active Not-in-force
- 2006-06-12 ES ES06779787T patent/ES2350853T3/es active Active
- 2006-06-12 DE DE602006017217T patent/DE602006017217D1/de active Active
- 2006-06-12 AT AT06779787T patent/ATE482940T1/de not_active IP Right Cessation
- 2006-06-12 WO PCT/IB2006/001773 patent/WO2006136944A1/en not_active Application Discontinuation
- 2006-06-12 JP JP2008517627A patent/JP2009501143A/ja active Pending
- 2006-06-12 US US11/993,387 patent/US20100160648A1/en not_active Abandoned
- 2006-06-12 CA CA2611035A patent/CA2611035C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009501143A (ja) | 2009-01-15 |
| EP1899310B1 (de) | 2010-09-29 |
| ATE482940T1 (de) | 2010-10-15 |
| CA2611035C (en) | 2010-09-14 |
| CA2611035A1 (en) | 2006-12-28 |
| EP1899310A1 (de) | 2008-03-19 |
| ES2350853T3 (es) | 2011-01-27 |
| US20100160648A1 (en) | 2010-06-24 |
| WO2006136944A1 (en) | 2006-12-28 |
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