DE602006012115D1 - Behandlung von amyotrophischer lateralsklerose mit pyrimethamin und analoga - Google Patents

Behandlung von amyotrophischer lateralsklerose mit pyrimethamin und analoga

Info

Publication number
DE602006012115D1
DE602006012115D1 DE602006012115T DE602006012115T DE602006012115D1 DE 602006012115 D1 DE602006012115 D1 DE 602006012115D1 DE 602006012115 T DE602006012115 T DE 602006012115T DE 602006012115 T DE602006012115 T DE 602006012115T DE 602006012115 D1 DE602006012115 D1 DE 602006012115D1
Authority
DE
Germany
Prior art keywords
pyrimethamine
analogue
treatment
lateral sclerosis
amyotrophic lateral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006012115T
Other languages
German (de)
English (en)
Inventor
Sean Scott
Daniel Benjamin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALSGEN Inc
Original Assignee
ALSGEN Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALSGEN Inc filed Critical ALSGEN Inc
Publication of DE602006012115D1 publication Critical patent/DE602006012115D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyurethanes Or Polyureas (AREA)
DE602006012115T 2005-03-04 2006-03-01 Behandlung von amyotrophischer lateralsklerose mit pyrimethamin und analoga Active DE602006012115D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65850505P 2005-03-04 2005-03-04
PCT/US2006/007257 WO2006096405A2 (en) 2005-03-04 2006-03-01 Treatment of amyotrophic lateral sclerosis with pyrimethamine and analogues

Publications (1)

Publication Number Publication Date
DE602006012115D1 true DE602006012115D1 (de) 2010-03-25

Family

ID=36953835

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006012115T Active DE602006012115D1 (de) 2005-03-04 2006-03-01 Behandlung von amyotrophischer lateralsklerose mit pyrimethamin und analoga

Country Status (10)

Country Link
US (1) US20060211645A1 (cg-RX-API-DMAC7.html)
EP (1) EP1917017B1 (cg-RX-API-DMAC7.html)
JP (1) JP2008531710A (cg-RX-API-DMAC7.html)
CN (1) CN101184493A (cg-RX-API-DMAC7.html)
AT (1) ATE456953T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006220919A1 (cg-RX-API-DMAC7.html)
CA (1) CA2600067A1 (cg-RX-API-DMAC7.html)
DE (1) DE602006012115D1 (cg-RX-API-DMAC7.html)
ES (1) ES2340708T3 (cg-RX-API-DMAC7.html)
WO (1) WO2006096405A2 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101232888A (zh) * 2005-03-04 2008-07-30 阿尔斯根公司 用炔诺酮及其类似物治疗肌萎缩性侧索硬化
US20070135437A1 (en) * 2005-03-04 2007-06-14 Alsgen, Inc. Modulation of neurodegenerative diseases
WO2006096415A2 (en) * 2005-03-04 2006-09-14 Alsgen, Llc Modulation of neurodegenerative diseases through the estrogen receptor
US20080153094A1 (en) * 2006-10-13 2008-06-26 Minor James M Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
AR076601A1 (es) 2009-05-21 2011-06-22 Chlorion Pharma Inc Pirimidinas como agentes terapeuticos
GB201015079D0 (en) 2010-09-10 2010-10-27 Helperby Therapeutics Ltd Novel use
SI2718270T1 (sl) 2011-06-10 2022-11-30 Merck Patent Gmbh Sestavki in postopki za proizvodnjo pirimidinskih in piridinskih spojin z BTK inhibitorno aktivnostjo
CN104398517A (zh) * 2014-11-28 2015-03-11 四川大学 乙胺嘧啶的新用途及治疗肿瘤的药物组合物
KR20210056931A (ko) * 2019-11-11 2021-05-20 에스케이케미칼 주식회사 피리메타민을 유효성분으로 포함하는 면역 관련 질환의 치료 또는 예방용 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231170A (en) * 1986-08-27 1993-07-27 Paul Averback Antibodies to dense microspheres
US5866562A (en) * 1996-10-25 1999-02-02 Bayer Aktiengesellschaft Ring-bridged bis-quinolines
US7442629B2 (en) * 2004-09-24 2008-10-28 President & Fellows Of Harvard College Femtosecond laser-induced formation of submicrometer spikes on a semiconductor substrate
KR101031720B1 (ko) * 2001-11-28 2011-04-29 비티지 인터내셔널 리미티드 질소함유 헤테로아릴 화합물을 함유하는 알츠하이머병의예방약 또는 치료약 또는 아밀로이드 단백질 섬유화억제제
KR20040099324A (ko) * 2002-03-13 2004-11-26 유로-셀티큐 에스.에이. 아릴 치환된 피리미딘 및 이것의 용도
US20050026823A1 (en) * 2003-06-20 2005-02-03 Biomarin Pharmaceutical Inc. Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
CN101232888A (zh) * 2005-03-04 2008-07-30 阿尔斯根公司 用炔诺酮及其类似物治疗肌萎缩性侧索硬化
US20070135437A1 (en) * 2005-03-04 2007-06-14 Alsgen, Inc. Modulation of neurodegenerative diseases

Also Published As

Publication number Publication date
WO2006096405A2 (en) 2006-09-14
EP1917017B1 (en) 2010-02-03
AU2006220919A1 (en) 2006-09-14
WO2006096405A8 (en) 2008-04-10
JP2008531710A (ja) 2008-08-14
US20060211645A1 (en) 2006-09-21
EP1917017A2 (en) 2008-05-07
ES2340708T3 (es) 2010-06-08
WO2006096405A3 (en) 2007-05-18
CA2600067A1 (en) 2006-09-14
CN101184493A (zh) 2008-05-21
ATE456953T1 (de) 2010-02-15

Similar Documents

Publication Publication Date Title
EA200602062A1 (ru) Амидосоединения и их применение в качестве фармацевтических средств
BRPI0413022A (pt) derivados de 3-amino cromado e 2-amino tetralina
EA200700118A1 (ru) Амидосоединения и их применение в качестве лекарственных средств
WO2008067389A3 (en) Modulation of sod protein synthesis for the treatment of neurodegenerative diseases
BRPI0508085A (pt) compostos de enxofre como inibidores da ns3 serina protease do vìrus da hepatite c
TW200612905A (en) Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EA200870019A1 (ru) Лактамовые соединения и способы их применения
BRPI0518281A2 (pt) inibidores de 11-beta hidroxilesteràide desidrogenase do tipo i e mÉtodos uso dos mesmos
TW200611702A (en) Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EA200700175A1 (ru) Композиции и способы лечения воспалительных заболеваний
ATE451376T1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
DE60327999D1 (de) Azolylaminoazine als inhibitoren von proteinkinasen
SG161261A1 (en) Lactam compounds and their use as pharmaceuticals
TW200531689A (en) Therapeutic agents
ATE497961T1 (de) Als proteinkinaseinhibitoren geeignete verbindungen
CY1112790T1 (el) Χρηση μαγιας σεληνιου στην αντιμετωπιση της νοσου αλτσχαιμερ
CL2007000789A1 (es) Compuestos derivados de malonamida, inhibidores de la gamma-secretasa; proceso de preparacion; composicion farmaceutica; y su uso en el tratamiento de la enfermedad de alzheimer.
MXPA06012500A (es) Compuestos para el tratamiento de la enfermedad de alzheimer y para la inhibicion de la produccion del peptido beta-amiloideo.
DE602006012115D1 (de) Behandlung von amyotrophischer lateralsklerose mit pyrimethamin und analoga
WO2008079270A3 (en) Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis
ATE433966T1 (de) Methylendipiperidinderivate
ATE538790T1 (de) Scopolamin für die behandlung von depression und ängstlichkeit
BRPI0506970B8 (pt) derivados de alfa-aminoamida úteis no tratamento de distúrbios do trato urinário inferior
ATE528309T1 (de) Als proteinkinaseinhibitoren geeignete verbindungen
ATE435858T1 (de) Prodrugs von als erk-proteinkinase-inhibitoren wirkenden pyrrolylpyrimidinen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition