DE602006009269D1 - Verfahren zur herstellung von eptifibatid - Google Patents
Verfahren zur herstellung von eptifibatidInfo
- Publication number
- DE602006009269D1 DE602006009269D1 DE602006009269T DE602006009269T DE602006009269D1 DE 602006009269 D1 DE602006009269 D1 DE 602006009269D1 DE 602006009269 T DE602006009269 T DE 602006009269T DE 602006009269 T DE602006009269 T DE 602006009269T DE 602006009269 D1 DE602006009269 D1 DE 602006009269D1
- Authority
- DE
- Germany
- Prior art keywords
- eptifibatide
- producing
- solution
- derivative
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 title abstract 5
- 108010056764 Eptifibatide Proteins 0.000 title abstract 2
- 229960004468 eptifibatide Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000006184 cosolvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69981805P | 2005-07-15 | 2005-07-15 | |
| PCT/EP2006/064253 WO2007009946A2 (en) | 2005-07-15 | 2006-07-14 | Process for the manufacture of eptifibatide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006009269D1 true DE602006009269D1 (de) | 2009-10-29 |
Family
ID=36992592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006009269T Expired - Fee Related DE602006009269D1 (de) | 2005-07-15 | 2006-07-14 | Verfahren zur herstellung von eptifibatid |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100125050A1 (de) |
| EP (2) | EP2145962B1 (de) |
| AT (1) | ATE443153T1 (de) |
| CA (1) | CA2614811C (de) |
| CH (1) | CH698710B1 (de) |
| DE (1) | DE602006009269D1 (de) |
| NL (1) | NL2000126C2 (de) |
| WO (1) | WO2007009946A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS51929B (en) | 2004-04-08 | 2012-02-29 | Millennium Pharmaceuticals Inc. | PROCEDURE FOR THE PREPARATION OF EPTIFIBATIDES AND RESPONSIBLE INTERMEDIATE UNITS |
| US20100317827A1 (en) * | 2008-02-06 | 2010-12-16 | Biocon Limited | Method of Purifying a Peptide |
| DE102014219095A1 (de) | 2014-09-22 | 2016-03-24 | Nissan Chemical Industries, Ltd. | Wafer-Träger-Anordnung |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2569384A (en) * | 1947-12-19 | 1951-09-25 | Standard Oil Dev Co | Recovery of oxygenated compounds from hydrocarbon oils |
| CH369468A (de) * | 1957-10-17 | 1963-05-31 | Hoffmann La Roche | Verfahren zur Herstellung von a-tert.-Aminoessigsäuren |
| US5795868A (en) | 1989-06-16 | 1998-08-18 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5843897A (en) * | 1989-06-16 | 1998-12-01 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
| SE510666C2 (sv) * | 1996-12-20 | 1999-06-14 | Astra Ab | Nya Kristallmodifikationer |
| US6518244B2 (en) * | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
| MXPA04010910A (es) * | 2002-05-03 | 2005-01-25 | Avecia Ltd | Procedimiento para la sintesis de peptidos. |
| RS51929B (en) * | 2004-04-08 | 2012-02-29 | Millennium Pharmaceuticals Inc. | PROCEDURE FOR THE PREPARATION OF EPTIFIBATIDES AND RESPONSIBLE INTERMEDIATE UNITS |
| CA2582083A1 (en) * | 2004-10-04 | 2006-04-20 | Novetide, Ltd. | A counterion exchange process for peptides |
| EP2119724A1 (de) * | 2005-05-03 | 2009-11-18 | Novetide Ltd. | Festphaseverfahren zur Herstellung von Goserelin |
-
2006
- 2006-07-05 NL NL2000126A patent/NL2000126C2/nl not_active IP Right Cessation
- 2006-07-14 CH CH00421/07A patent/CH698710B1/fr not_active IP Right Cessation
- 2006-07-14 WO PCT/EP2006/064253 patent/WO2007009946A2/en active Application Filing
- 2006-07-14 CA CA2614811A patent/CA2614811C/en not_active Expired - Fee Related
- 2006-07-14 EP EP09170310.8A patent/EP2145962B1/de not_active Not-in-force
- 2006-07-14 AT AT06777777T patent/ATE443153T1/de not_active IP Right Cessation
- 2006-07-14 EP EP06777777A patent/EP1904641B1/de not_active Not-in-force
- 2006-07-14 DE DE602006009269T patent/DE602006009269D1/de not_active Expired - Fee Related
- 2006-07-14 US US11/995,476 patent/US20100125050A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2145962A2 (de) | 2010-01-20 |
| NL2000126C2 (nl) | 2008-01-29 |
| EP1904641A2 (de) | 2008-04-02 |
| US20100125050A1 (en) | 2010-05-20 |
| EP1904641B1 (de) | 2009-09-16 |
| CH698710B1 (fr) | 2009-10-15 |
| EP2145962A3 (de) | 2010-04-07 |
| WO2007009946A3 (en) | 2007-03-29 |
| NL2000126A1 (nl) | 2006-11-07 |
| EP2145962B1 (de) | 2016-11-16 |
| CA2614811C (en) | 2016-02-23 |
| CA2614811A1 (en) | 2007-01-25 |
| ATE443153T1 (de) | 2009-10-15 |
| WO2007009946A2 (en) | 2007-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |