DE602005021135D1 - Verfahren zur veränderung der oberflächeneigenschaften von mikrokügelchen - Google Patents

Verfahren zur veränderung der oberflächeneigenschaften von mikrokügelchen

Info

Publication number
DE602005021135D1
DE602005021135D1 DE602005021135T DE602005021135T DE602005021135D1 DE 602005021135 D1 DE602005021135 D1 DE 602005021135D1 DE 602005021135 T DE602005021135 T DE 602005021135T DE 602005021135 T DE602005021135 T DE 602005021135T DE 602005021135 D1 DE602005021135 D1 DE 602005021135D1
Authority
DE
Germany
Prior art keywords
microsphere
surface characteristics
reagent
enolic acid
coupled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021135T
Other languages
English (en)
Inventor
Ananda G Lugade
Kurt D Hoffacker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Luminex Corp
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Corp filed Critical Luminex Corp
Publication of DE602005021135D1 publication Critical patent/DE602005021135D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G01N33/546—Synthetic resin as water suspendable particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2650/00—Assays involving polymers whose constituent monomers bore biological functional groups before polymerization, i.e. vinyl, acryl derivatives of amino acids, sugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicinal Preparation (AREA)
DE602005021135T 2004-10-12 2005-10-11 Verfahren zur veränderung der oberflächeneigenschaften von mikrokügelchen Active DE602005021135D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61833804P 2004-10-12 2004-10-12
PCT/US2005/036264 WO2006044275A2 (en) 2004-10-12 2005-10-11 Methods for altering surface characteristics of microspheres

Publications (1)

Publication Number Publication Date
DE602005021135D1 true DE602005021135D1 (de) 2010-06-17

Family

ID=35709114

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021135T Active DE602005021135D1 (de) 2004-10-12 2005-10-11 Verfahren zur veränderung der oberflächeneigenschaften von mikrokügelchen

Country Status (9)

Country Link
US (2) US7867774B2 (de)
EP (1) EP1802973B1 (de)
JP (1) JP4988578B2 (de)
KR (1) KR101230020B1 (de)
CN (1) CN101044403B (de)
AT (1) ATE467127T1 (de)
CA (1) CA2583474C (de)
DE (1) DE602005021135D1 (de)
WO (1) WO2006044275A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010019718A2 (en) * 2008-08-13 2010-02-18 California Institute Of Technology Carrier nanoparticles and related compositions, methods and systems
US9132097B2 (en) 2013-03-01 2015-09-15 California Institute Of Technology Nanoparticles stabilized with nitrophenylboronic acid compositions
JP6251294B2 (ja) * 2013-03-01 2017-12-20 カリフォルニア インスティテュート オブ テクノロジー 標的化ナノ粒子
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
US9211314B2 (en) 2014-04-04 2015-12-15 Biodesix, Inc. Treatment selection for lung cancer patients using mass spectrum of blood-based sample
US11754563B2 (en) * 2014-11-20 2023-09-12 Global Life Sciences Solutions Operations UK Ltd Porous membranes with a polymer grafting, methods and uses thereof
ES2882255T3 (es) 2015-07-01 2021-12-01 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
JP2019108371A (ja) * 2019-03-04 2019-07-04 カリフォルニア インスティテュート オブ テクノロジー 標的化ナノ粒子
CN109946453A (zh) * 2019-04-02 2019-06-28 珠海丽珠试剂股份有限公司 一种增殖细胞核抗原的偶联方法
EP4069707A4 (de) 2019-12-04 2023-12-06 Dantari, Inc. Verfahren und zusammensetzungen zur synthese von therapeutischen nanopartikeln

Family Cites Families (28)

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Publication number Priority date Publication date Assignee Title
DE960534C (de) 1950-01-09 1957-03-21 Hoechst Ag Verfahren zur Herstellung echter Faerbungen und Drucke
BE507417A (de) * 1950-01-09
US4935147A (en) * 1985-12-20 1990-06-19 Syntex (U.S.A.) Inc. Particle separation method
CA1304006C (en) 1985-12-20 1992-06-23 Edwin F. Ullman Particle separation method
US5414135A (en) * 1991-12-30 1995-05-09 Sterling Winthrop Inc. Vinyl sulfone coupling of polyoxyalkylenes to proteins
GB9304979D0 (en) * 1993-03-11 1993-04-28 Sinvent As Imobilisation and separation of cells and other particles
CA2164725A1 (en) * 1993-06-08 1994-12-22 Alexander Saunders Two-phase optical assay method and apparatus
DE4341524C2 (de) * 1993-12-06 1997-01-16 Gluesenkamp Karl Heinz Dr Verfahren zur Immobilisierung von Biomolekülen und Affinitätsliganden an polymere Träger
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
JPH0892294A (ja) 1994-09-29 1996-04-09 Teijin Ltd ヒト活性化プロテインｃ誘導体
CA2227895C (en) * 1995-10-11 2012-07-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US6075126A (en) * 1996-08-05 2000-06-13 Prolinx, Inc. Phenyldiboronic acid reagents and complexes
US6630577B2 (en) * 1996-08-05 2003-10-07 Prolinx, Inc. 1,2-Phenylenediboronic acid reagents and complexes
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6146833A (en) * 1997-02-11 2000-11-14 Beckman Coulter, Inc. Polymeric reagents for immobilizing biopolymers
WO1998059233A1 (en) * 1997-06-23 1998-12-30 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
AU1080999A (en) * 1997-10-14 1999-05-03 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
WO1999037814A1 (en) * 1998-01-22 1999-07-29 Luminex Corporation Microparticles with multiple fluorescent signals
AU4184099A (en) * 1998-05-14 1999-11-29 Luminex Corporation Zero dead time architecture and method for flow cytometer
WO1999058958A1 (en) * 1998-05-14 1999-11-18 Luminex Corporation Diode laser based measurement apparatus
WO1999067228A1 (en) 1998-06-24 1999-12-29 Aventis Pharmaceuticals Products Inc. Fluorophenyl resin compounds
ES2272099T3 (es) * 1998-10-16 2007-04-16 Ge Healthcare Bio-Sciences Ab Composicion estable en el almacenamiento que comprende un soporte activado por acido escuarico utilizable para la inmovilizacion de compuestos que contienen grupos de amina.
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US20050118199A1 (en) * 2003-10-07 2005-06-02 Esser Mark T. Process for covalently conjugating polysaccharides to microspheres or biomolecules

Also Published As

Publication number Publication date
CA2583474C (en) 2013-12-03
CN101044403B (zh) 2012-10-31
KR101230020B1 (ko) 2013-02-05
CA2583474A1 (en) 2006-04-27
US8153440B2 (en) 2012-04-10
ATE467127T1 (de) 2010-05-15
KR20070085341A (ko) 2007-08-27
EP1802973A2 (de) 2007-07-04
WO2006044275A2 (en) 2006-04-27
JP2008516240A (ja) 2008-05-15
JP4988578B2 (ja) 2012-08-01
EP1802973B1 (de) 2010-05-05
US20060078997A1 (en) 2006-04-13
CN101044403A (zh) 2007-09-26
US7867774B2 (en) 2011-01-11
US20110086431A1 (en) 2011-04-14
WO2006044275A3 (en) 2007-04-26

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