DE602005020042D1 - Verfahren zur abschätzung des metabolismus eines arzneistoffs in der menschlichen leber sowie der leberfunktion - Google Patents

Verfahren zur abschätzung des metabolismus eines arzneistoffs in der menschlichen leber sowie der leberfunktion

Info

Publication number
DE602005020042D1
DE602005020042D1 DE602005020042T DE602005020042T DE602005020042D1 DE 602005020042 D1 DE602005020042 D1 DE 602005020042D1 DE 602005020042 T DE602005020042 T DE 602005020042T DE 602005020042 T DE602005020042 T DE 602005020042T DE 602005020042 D1 DE602005020042 D1 DE 602005020042D1
Authority
DE
Germany
Prior art keywords
liver
chimeric animal
human
metabolism
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005020042T
Other languages
English (en)
Inventor
Shin-Ichi Ninomiya
Yoshihiro Ohzone
Yasuhisa Adachi
Toru Horie
Yoshinori Soeno
Tae Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phoenixbio Co Ltd
Sekisui Medical Co Ltd
Original Assignee
Phoenixbio Co Ltd
Sekisui Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phoenixbio Co Ltd, Sekisui Medical Co Ltd filed Critical Phoenixbio Co Ltd
Publication of DE602005020042D1 publication Critical patent/DE602005020042D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DE602005020042T 2004-08-20 2005-08-19 Verfahren zur abschätzung des metabolismus eines arzneistoffs in der menschlichen leber sowie der leberfunktion Active DE602005020042D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004240827 2004-08-20
PCT/JP2005/015148 WO2006019162A1 (ja) 2004-08-20 2005-08-19 薬物のヒトにおける肝代謝及び肝機能を予測する方法

Publications (1)

Publication Number Publication Date
DE602005020042D1 true DE602005020042D1 (de) 2010-04-29

Family

ID=35907545

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005020042T Active DE602005020042D1 (de) 2004-08-20 2005-08-19 Verfahren zur abschätzung des metabolismus eines arzneistoffs in der menschlichen leber sowie der leberfunktion

Country Status (9)

Country Link
US (1) US20080199847A1 (de)
EP (1) EP1801582B1 (de)
JP (1) JP4854509B2 (de)
KR (1) KR101159573B1 (de)
CN (1) CN101014855A (de)
AT (1) ATE461448T1 (de)
CA (1) CA2577644C (de)
DE (1) DE602005020042D1 (de)
WO (1) WO2006019162A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006054755A1 (ja) * 2004-11-16 2008-06-05 財団法人 ひろしま産業振興機構 医薬候補物質のスクリーニング方法
JP2011106846A (ja) * 2009-11-13 2011-06-02 Hamamatsu Univ School Of Medicine 新規ｎｓａｉｄ潰瘍リスク判定方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106368A0 (en) * 1992-07-24 1993-11-15 Univ Pennsylvania Non-native liver generation in an animal with impaired native liver function,by cell implantation
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
KR100873690B1 (ko) * 1999-01-19 2008-12-12 유니버시티 오브 노스캐롤라이나 앳 채플 힐 인간 간 전구세포
US6525242B1 (en) * 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6509514B1 (en) * 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection
JP2002045087A (ja) * 2000-05-19 2002-02-12 Japan Science & Technology Corp キメラ動物
US7211404B2 (en) * 2001-06-22 2007-05-01 Stem Cells, Inc. Liver engrafting cells, assays, and uses thereof
EP1496110B1 (de) * 2002-03-25 2012-05-09 Hiroshima Industrial Promotion Organization Verfahren zur vermehrung menschlicher hepatozyten und verfahren zur gewinnung menschlicher hepatozyten
EP1552740A1 (de) * 2004-01-09 2005-07-13 Institut Pasteur Chimaeres Mausmodell enthaltend humane Hepatocyten - Anwendung zum Screening von Verbindungen

Also Published As

Publication number Publication date
EP1801582A4 (de) 2007-12-19
KR20070051277A (ko) 2007-05-17
EP1801582B1 (de) 2010-03-17
EP1801582A1 (de) 2007-06-27
CA2577644A1 (en) 2006-02-23
JPWO2006019162A1 (ja) 2008-05-08
CN101014855A (zh) 2007-08-08
US20080199847A1 (en) 2008-08-21
WO2006019162A1 (ja) 2006-02-23
JP4854509B2 (ja) 2012-01-18
KR101159573B1 (ko) 2012-06-26
CA2577644C (en) 2012-11-27
ATE461448T1 (de) 2010-04-15

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