DE602005018834D1 - Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino-beta-hydroxybuttersäure ((r)-gabob) und (r)-carnitin - Google Patents

Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino-beta-hydroxybuttersäure ((r)-gabob) und (r)-carnitin

Info

Publication number
DE602005018834D1
DE602005018834D1 DE602005018834T DE602005018834T DE602005018834D1 DE 602005018834 D1 DE602005018834 D1 DE 602005018834D1 DE 602005018834 T DE602005018834 T DE 602005018834T DE 602005018834 T DE602005018834 T DE 602005018834T DE 602005018834 D1 DE602005018834 D1 DE 602005018834D1
Authority
DE
Germany
Prior art keywords
gabob
carnitine
stereoselective
gamma
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005018834T
Other languages
English (en)
Inventor
Ahmed Kamal
Gollapalli B R Khanna
T Krishnaji
Rondla Ramu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research CSIR
Original Assignee
Council of Scientific and Industrial Research CSIR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR
Publication of DE602005018834D1 publication Critical patent/DE602005018834D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602005018834T 2005-04-15 2005-11-29 Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino-beta-hydroxybuttersäure ((r)-gabob) und (r)-carnitin Active DE602005018834D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN963DE2005 2005-04-15
PCT/IN2005/000387 WO2006109322A1 (en) 2005-04-15 2005-11-29 A chemoenzymatic process for the stereoselective preparation of (r)-gamma-amino-beta-hydroxybutyric acid ((r) -gabob) and (r)-carnitine

Publications (1)

Publication Number Publication Date
DE602005018834D1 true DE602005018834D1 (de) 2010-02-25

Family

ID=36087740

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005018834T Active DE602005018834D1 (de) 2005-04-15 2005-11-29 Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino-beta-hydroxybuttersäure ((r)-gabob) und (r)-carnitin

Country Status (5)

Country Link
US (1) US7816119B2 (de)
EP (1) EP1869199B1 (de)
AT (1) ATE454460T1 (de)
DE (1) DE602005018834D1 (de)
WO (1) WO2006109322A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102432483A (zh) * 2011-09-23 2012-05-02 李氏大药厂（香港）有限公司 乙酰左卡尼汀盐酸盐的制备方法及其药物用途
CN111621494B (zh) * 2020-07-07 2021-04-02 厦门庚能新材料技术有限公司 一种磁性固定化脂肪酶的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248601A (en) * 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
JPH0227995A (ja) * 1988-07-15 1990-01-30 Earth Chem Corp Ltd ｌ‐カルニチンクロライドの製造法
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
US7374926B2 (en) * 2004-12-23 2008-05-20 Council Of Scientific And Industrial Research Enantioconvergent chemoenzymatic synthesis of (R)-γ-amino-β-hydroxybutyric acid ((R)-GABOB)

Also Published As

Publication number Publication date
US7816119B2 (en) 2010-10-19
US20090233337A1 (en) 2009-09-17
EP1869199A1 (de) 2007-12-26
EP1869199B1 (de) 2010-01-06
ATE454460T1 (de) 2010-01-15
WO2006109322A1 (en) 2006-10-19

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Legal Events

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8328 Change in the person/name/address of the agent

Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803

8364 No opposition during term of opposition