DE602005008721D1 - Verfahren zur herstellung von festen dosierformen von amorphem valganciclovir-hydrochlorid - Google Patents
Verfahren zur herstellung von festen dosierformen von amorphem valganciclovir-hydrochloridInfo
- Publication number
- DE602005008721D1 DE602005008721D1 DE602005008721T DE602005008721T DE602005008721D1 DE 602005008721 D1 DE602005008721 D1 DE 602005008721D1 DE 602005008721 T DE602005008721 T DE 602005008721T DE 602005008721 T DE602005008721 T DE 602005008721T DE 602005008721 D1 DE602005008721 D1 DE 602005008721D1
- Authority
- DE
- Germany
- Prior art keywords
- dosage forms
- solid dosage
- amorphem
- producing solid
- valganciclovir hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- ZORWARFPXPVJLW-MTFPJWTKSA-N [2-[(2-amino-6-oxo-3h-purin-9-yl)methoxy]-3-hydroxypropyl] (2s)-2-amino-3-methylbutanoate;hydron;chloride Chemical compound Cl.N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 ZORWARFPXPVJLW-MTFPJWTKSA-N 0.000 title abstract 2
- 239000007909 solid dosage form Substances 0.000 title abstract 2
- 229960004983 valganciclovir hydrochloride Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN410DE2004 | 2004-03-10 | ||
| PCT/IB2005/000615 WO2005087198A1 (en) | 2004-03-10 | 2005-03-10 | Processes for the preparation of solid dosage forms of amorphous valganciclovir hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005008721D1 true DE602005008721D1 (de) | 2008-09-18 |
Family
ID=34961286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005008721T Active DE602005008721D1 (de) | 2004-03-10 | 2005-03-10 | Verfahren zur herstellung von festen dosierformen von amorphem valganciclovir-hydrochlorid |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070292499A1 (de) |
| EP (1) | EP1725217B1 (de) |
| AT (1) | ATE403418T1 (de) |
| DE (1) | DE602005008721D1 (de) |
| WO (1) | WO2005087198A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2671470C (en) | 2006-12-13 | 2012-05-01 | F. Hoffmann-La Roche Ag | Powder formulation for valganciclovir |
| US20100298564A1 (en) * | 2009-05-25 | 2010-11-25 | Venu Nalivela | Preparation of amorphous valganciclovir hydrochloride |
| CN104055746B (zh) * | 2014-07-12 | 2017-06-30 | 河北仁合益康药业有限公司 | 一种盐酸缬更昔洛韦包衣片剂组合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292534A (en) * | 1992-03-25 | 1994-03-08 | Valentine Enterprises, Inc. | Sustained release composition and method utilizing xanthan gum and an active ingredient |
| US5856481A (en) * | 1994-07-28 | 1999-01-05 | Syntex (U.S.A.) Inc. | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
| US6395029B1 (en) * | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| CA2371940C (en) * | 1999-03-31 | 2008-07-15 | Janssen Pharmaceutica N.V. | Pregelatinized starch in a controlled release formulation |
| US6660303B2 (en) * | 1999-12-06 | 2003-12-09 | Edward Mendell & Co. | Pharmaceutical superdisintegrant |
| US20070196481A1 (en) * | 2002-07-25 | 2007-08-23 | Amidon Gregory E | Sustained-release tablet composition |
| US20070129385A1 (en) * | 2003-08-28 | 2007-06-07 | Sharma Mukesh K | Amorphous valganciclovir hydrochloride |
| US8771735B2 (en) * | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
-
2005
- 2005-03-10 WO PCT/IB2005/000615 patent/WO2005087198A1/en active IP Right Grant
- 2005-03-10 US US10/598,546 patent/US20070292499A1/en not_active Abandoned
- 2005-03-10 EP EP05708710A patent/EP1725217B1/de active Active
- 2005-03-10 AT AT05708710T patent/ATE403418T1/de not_active IP Right Cessation
- 2005-03-10 DE DE602005008721T patent/DE602005008721D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1725217A1 (de) | 2006-11-29 |
| WO2005087198A1 (en) | 2005-09-22 |
| EP1725217B1 (de) | 2008-08-06 |
| ATE403418T1 (de) | 2008-08-15 |
| US20070292499A1 (en) | 2007-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |