DE602005000874D1 - Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke - Google Patents

Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke

Info

Publication number
DE602005000874D1
DE602005000874D1 DE602005000874T DE602005000874T DE602005000874D1 DE 602005000874 D1 DE602005000874 D1 DE 602005000874D1 DE 602005000874 T DE602005000874 T DE 602005000874T DE 602005000874 T DE602005000874 T DE 602005000874T DE 602005000874 D1 DE602005000874 D1 DE 602005000874D1
Authority
DE
Germany
Prior art keywords
zebrief
blood brain
screening method
brain barriers
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE602005000874T
Other languages
English (en)
Other versions
DE602005000874T2 (de
Inventor
Paul Daniolabs Li Goldsmith
Angeleen Louise Fleming
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Summit (camdridge) Ltd Cambridge Cambrigesh Gb
Original Assignee
Daniolabs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32039873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005000874(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daniolabs Ltd filed Critical Daniolabs Ltd
Publication of DE602005000874D1 publication Critical patent/DE602005000874D1/de
Application granted granted Critical
Publication of DE602005000874T2 publication Critical patent/DE602005000874T2/de
Revoked legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DE602005000874T 2004-02-17 2005-02-17 Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke Revoked DE602005000874T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0403490 2004-02-17
GBGB0403490.6A GB0403490D0 (en) 2004-02-17 2004-02-17 Screening methods
PCT/GB2005/000583 WO2005080974A1 (en) 2004-02-17 2005-02-17 Screening methods employing zebrafish and the blood brain barrier

Publications (2)

Publication Number Publication Date
DE602005000874D1 true DE602005000874D1 (de) 2007-05-24
DE602005000874T2 DE602005000874T2 (de) 2008-01-17

Family

ID=32039873

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005000874T Revoked DE602005000874T2 (de) 2004-02-17 2005-02-17 Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke

Country Status (10)

Country Link
US (1) US20060193776A1 (de)
EP (1) EP1644733B1 (de)
JP (1) JP2007525665A (de)
AT (1) ATE359508T1 (de)
AU (1) AU2005215455A1 (de)
CA (1) CA2556680A1 (de)
DE (1) DE602005000874T2 (de)
ES (1) ES2286794T3 (de)
GB (1) GB0403490D0 (de)
WO (1) WO2005080974A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4383533B2 (ja) * 1998-02-23 2009-12-16 フィロニクス ファーマシューティカルズ， インコーポレイテッド 真骨魚類を使用する、活性についての薬剤のスクリーニング方法
US7951989B2 (en) * 1998-02-23 2011-05-31 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
US6656449B1 (en) * 1998-02-23 2003-12-02 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
WO2005098428A2 (en) * 2004-04-07 2005-10-20 Marinus Pharmaceuticals, Inc. Method and system for screening compounds for muscular and/or neurological activity in animals
WO2010031794A1 (en) * 2008-09-22 2010-03-25 Entomopharm Aps Screening methods employing insects with blood brain barrier
EP2399612B1 (de) * 2009-12-25 2018-02-21 Canon Kabushiki Kaisha Zusammensetzung zur gewebekennzeichnung im zentralnervensystem, verfahren zur gewebekennzeichnung im zentralnervensystem und screening-verfahren mit der zusammensetzung zur gewebekennzeichnung im zentralnervensystem
WO2011077733A1 (ja) 2009-12-25 2011-06-30 キヤノン株式会社 経鼻中枢神経系組織標識用組成物、経鼻中枢神経系組織標識用組成物を用いた標識方法及びスクリーニング方法
JP5888904B2 (ja) 2011-02-16 2016-03-22 国立大学法人三重大学 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法
CN102288750B (zh) * 2011-08-12 2014-04-16 杭州环特生物科技有限公司 斑马鱼p-糖蛋白抑制剂筛选模型的建立方法及其应用
US10143187B2 (en) 2017-02-17 2018-12-04 Denali Therapeutics Inc. Transferrin receptor transgenic models
DK3583120T3 (da) 2017-02-17 2022-12-19 Denali Therapeutics Inc Modificerede transferrinreceptorbindende polypeptider
US10457717B2 (en) 2017-02-17 2019-10-29 Denali Therapeutics Inc. Engineered polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4383533B2 (ja) * 1998-02-23 2009-12-16 フィロニクス ファーマシューティカルズ， インコーポレイテッド 真骨魚類を使用する、活性についての薬剤のスクリーニング方法

Also Published As

Publication number Publication date
EP1644733A1 (de) 2006-04-12
CA2556680A1 (en) 2005-09-01
AU2005215455A1 (en) 2005-09-01
JP2007525665A (ja) 2007-09-06
US20060193776A1 (en) 2006-08-31
DE602005000874T2 (de) 2008-01-17
WO2005080974A1 (en) 2005-09-01
EP1644733B1 (de) 2007-04-11
ES2286794T3 (es) 2007-12-01
GB0403490D0 (en) 2004-03-24
ATE359508T1 (de) 2007-05-15

Similar Documents

Publication Publication Date Title
DE602005000874D1 (de) Screening-verfahren unter verwendung von zebrafisch und der blut-hirn-schranke
DE602004009171D1 (de) Methode und vorrichtung zur verbesserung des ventrikulären status unter verwendung der kraft-intervall-beziehung
WO2007084979A3 (en) Method to quantitatively measure effect of psychotropic drugs on sensory discrimination
ATE457773T1 (de) Mittel zur funktionalen wiederherstellung eines geschädigten nervensystems
WO2004037204A3 (en) Methods and compounds for disruption of cd40r/cd40l signaling in the treatment of alzheimer's disease
ATE397676T1 (de) Identifikation und verwendung von mirnas zur differenzierung myelogener leukämiezellen
DE602004026767D1 (de) Immunsorbens-bluttests zur beurteilung von paroxysmalen zerebralentladungen
ATE520974T1 (de) Raman-spektralanalyse von unter der oberfläche liegenden geweben und flüssigkeiten
DE602005009060D1 (de) System und Vorrichtung zur Verwaltung von Artikeln
DE602006019413D1 (de) Verfahren und vorrichtung zur herstellung von elektrogesponnenen fasern und damit hergestellte fasern
DE602005014134D1 (de) Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten
DK1292680T3 (da) Agonist-anti-TrkC monoklonale antistoffer
MX2009006685A (es) Antagonistas del dr6 y usos de los mismos en el tratamiento de trastornos neurologicos.
EP1862433A4 (de) Personalisierter synthetischer diamant mit verschiedenen farben, erhalten aus keratin (lebender oder toter) menschen oder tiere und herstellungsverfahren dafür
DE602005000024D1 (de) System zur Verwaltung von Erfassungshilfsinformationen, Vorrichtung zur Verwaltung von Erfassungshilfsinformationen und Methode zur Verwaltung von Erfassungshilfsinformationen
ATE462140T1 (de) Verfahren zum nachweis aggregatbildender zirkulierender proteinformen und mittel zum einfangen gebildeter aggregate
DE502004010500D1 (de) Vorrichtung zur koagulation von gewebe
DE602004001627D1 (de) Methode zur Racemisierung von (S)-(+)- und (R)-(-)-10,11-Dihydro-10-hydroxy-5H-dibenzib,föazepine-5-carboxamiden und optisch angereicherten Mischungen davon
ATE489628T1 (de) Galk1s als modifikatoren des pten/akt-wegs
DE60327533D1 (de) Vorrichtung zur transcervicalen sterilisierung unter verwendung von ultraschall
ATE534902T1 (de) Replikationsproteinn ciz1
WO2005016279A3 (en) Melks as modifiers of the rac pathway and methods of use
ATE536549T1 (de) Galnts als modifikatoren des igfr-weges und verwendungsverfahren
DE602005025737D1 (de) C20orf23 als modifikator des igfr-wegs und verwendungsverfahren
ATE501278T1 (de) Verfahren zur verwendung von il-21

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: SUMMIT (CAMDRIDGE) LTD., CAMBRIDGE, CAMBRIGESH, GB

8331 Complete revocation