DE602004031284D1 - Transposon-system zur gezielten integration - Google Patents
Transposon-system zur gezielten integrationInfo
- Publication number
- DE602004031284D1 DE602004031284D1 DE602004031284T DE602004031284T DE602004031284D1 DE 602004031284 D1 DE602004031284 D1 DE 602004031284D1 DE 602004031284 T DE602004031284 T DE 602004031284T DE 602004031284 T DE602004031284 T DE 602004031284T DE 602004031284 D1 DE602004031284 D1 DE 602004031284D1
- Authority
- DE
- Germany
- Prior art keywords
- transposase
- fragment
- derivative
- function
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000010354 integration Effects 0.000 title 1
- 102000008579 Transposases Human genes 0.000 abstract 9
- 108010020764 Transposases Proteins 0.000 abstract 9
- 239000012634 fragment Substances 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 230000008685 targeting Effects 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03002630 | 2003-02-10 | ||
PCT/EP2004/001222 WO2004069995A2 (en) | 2003-02-10 | 2004-02-10 | Transposon-based targeting system |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004031284D1 true DE602004031284D1 (de) | 2011-03-17 |
Family
ID=32842693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004031284T Expired - Lifetime DE602004031284D1 (de) | 2003-02-10 | 2004-02-10 | Transposon-system zur gezielten integration |
Country Status (7)
Country | Link |
---|---|
US (1) | US20060236413A1 (de) |
EP (1) | EP1594971B1 (de) |
JP (1) | JP2006517104A (de) |
AT (1) | ATE497540T1 (de) |
DE (1) | DE602004031284D1 (de) |
DK (1) | DK1594971T3 (de) |
WO (1) | WO2004069995A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040172667A1 (en) | 2002-06-26 | 2004-09-02 | Cooper Richard K. | Administration of transposon-based vectors to reproductive organs |
US7527966B2 (en) * | 2002-06-26 | 2009-05-05 | Transgenrx, Inc. | Gene regulation in transgenic animals using a transposon-based vector |
ATE536419T1 (de) * | 2003-02-10 | 2011-12-15 | Max Delbrueck Centrum | Transposon basiertes targeting- system |
US8071364B2 (en) | 2003-12-24 | 2011-12-06 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
EP2067402A1 (de) | 2007-12-07 | 2009-06-10 | Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; | Transposon-vermittelte Mutagenese in Spermatogoniestammzellen |
WO2010036976A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of antibodies |
WO2010036978A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of growth hormone |
EP2369916A4 (de) | 2008-12-01 | 2013-04-10 | Univ Texas | Herstellung und verfwendung von spermatogonialen stammzelllinien aus der ratte |
WO2010118360A1 (en) | 2009-04-09 | 2010-10-14 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Production of proteins using transposon-based vectors |
US9074251B2 (en) * | 2011-02-10 | 2015-07-07 | Illumina, Inc. | Linking sequence reads using paired code tags |
AU2012212148B8 (en) | 2011-02-02 | 2017-07-06 | University Of Washington Through Its Center For Commercialization | Massively parallel contiguity mapping |
EP2740353A1 (de) | 2012-12-06 | 2014-06-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Neuartige induzierbare Tiermodelle für Stressverhalten |
US9683230B2 (en) | 2013-01-09 | 2017-06-20 | Illumina Cambridge Limited | Sample preparation on a solid support |
AU2013382098B2 (en) | 2013-03-13 | 2019-02-07 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
WO2014143383A1 (en) * | 2013-03-13 | 2014-09-18 | Agilent Technologies, Inc. | Transposome tethered to a gene delivery vehicle |
US10246746B2 (en) | 2013-12-20 | 2019-04-02 | Illumina, Inc. | Preserving genomic connectivity information in fragmented genomic DNA samples |
FR3024464A1 (fr) * | 2014-07-30 | 2016-02-05 | Centre Nat Rech Scient | Ciblage de vecteurs integratifs non-viraux dans les sequences d'adn nucleolaires chez les eucaryotes |
JP6808617B2 (ja) | 2014-10-17 | 2021-01-06 | イルミナ ケンブリッジ リミテッド | 連続性を維持した転位 |
US11913015B2 (en) | 2017-04-17 | 2024-02-27 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994027643A1 (en) * | 1993-06-01 | 1994-12-08 | Targeted Genetics Corporation | Envelope fusion vectors for use in gene delivery |
KR0166606B1 (ko) * | 1993-12-07 | 1999-04-15 | 가네코 야스조 | 배선용 바닥 재료 |
CA2280997C (en) * | 1997-03-11 | 2013-05-28 | Perry B. Hackett | Dna-based transposon system for the introduction of nucleic acid into dna of a cell |
WO1999005295A1 (en) * | 1997-07-25 | 1999-02-04 | Thomas Jefferson University | Composition and method for targeted integration into cells |
WO2001030965A2 (en) * | 1999-10-28 | 2001-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of in vivo gene transfer using a sleeping beauty transposon system |
IL154059A0 (en) * | 2000-07-21 | 2003-07-31 | Syngenta Participations Ag | Zinc finger domain recognition code and uses thereof |
ES2358994T3 (es) * | 2002-07-24 | 2011-05-17 | Manoa Biosciences Inc. | Vectores basados en transposones y métodos para la integración de ácidos nucleicos. |
-
2004
- 2004-02-10 JP JP2006501792A patent/JP2006517104A/ja active Pending
- 2004-02-10 EP EP04709591A patent/EP1594971B1/de not_active Expired - Lifetime
- 2004-02-10 DE DE602004031284T patent/DE602004031284D1/de not_active Expired - Lifetime
- 2004-02-10 AT AT04709591T patent/ATE497540T1/de not_active IP Right Cessation
- 2004-02-10 DK DK04709591.4T patent/DK1594971T3/da active
- 2004-02-10 WO PCT/EP2004/001222 patent/WO2004069995A2/en active Application Filing
- 2004-02-10 US US10/544,879 patent/US20060236413A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006517104A (ja) | 2006-07-20 |
EP1594971B1 (de) | 2011-02-02 |
US20060236413A1 (en) | 2006-10-19 |
DK1594971T3 (da) | 2011-05-23 |
WO2004069995A3 (en) | 2004-10-28 |
EP1594971A2 (de) | 2005-11-16 |
WO2004069995A2 (en) | 2004-08-19 |
ATE497540T1 (de) | 2011-02-15 |
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