DE602004019659D1 - Verfahren zum nachweis geringer konzentrationen eines fusionsproteins - Google Patents

Verfahren zum nachweis geringer konzentrationen eines fusionsproteins

Info

Publication number
DE602004019659D1
DE602004019659D1 DE602004019659T DE602004019659T DE602004019659D1 DE 602004019659 D1 DE602004019659 D1 DE 602004019659D1 DE 602004019659 T DE602004019659 T DE 602004019659T DE 602004019659 T DE602004019659 T DE 602004019659T DE 602004019659 D1 DE602004019659 D1 DE 602004019659D1
Authority
DE
Germany
Prior art keywords
fusion protein
sample
protein
binding molecule
low concentrations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004019659T
Other languages
English (en)
Inventor
Frank Jakob Staal
Dongen Jacobus Johannes Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erasmus University Medical Center
Original Assignee
Erasmus University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erasmus University Medical Center filed Critical Erasmus University Medical Center
Publication of DE602004019659D1 publication Critical patent/DE602004019659D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE602004019659T 2003-08-12 2004-08-11 Verfahren zum nachweis geringer konzentrationen eines fusionsproteins Active DE602004019659D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03077529A EP1507147A1 (de) 2003-08-12 2003-08-12 Verfahren zum Nachweiss von niedrigem Gehalt an Fusionsprotein
PCT/NL2004/000562 WO2005015235A1 (en) 2003-08-12 2004-08-11 Method for detecting low levels of a fusion protein

Publications (1)

Publication Number Publication Date
DE602004019659D1 true DE602004019659D1 (de) 2009-04-09

Family

ID=33560826

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004019659T Active DE602004019659D1 (de) 2003-08-12 2004-08-11 Verfahren zum nachweis geringer konzentrationen eines fusionsproteins

Country Status (11)

Country Link
US (1) US20060172345A1 (de)
EP (2) EP1507147A1 (de)
JP (1) JP2007502404A (de)
CN (1) CN1836165B (de)
AT (1) ATE423974T1 (de)
AU (1) AU2004264178A1 (de)
CA (1) CA2535073A1 (de)
DE (1) DE602004019659D1 (de)
DK (1) DK1660888T3 (de)
ES (1) ES2323067T3 (de)
WO (1) WO2005015235A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1565746T3 (da) 2002-11-07 2011-01-10 Univ Erasmus Fremgangsmåde og prober til detektion af et tumor-specifikt fusionsprotein
EP2108956A1 (de) * 2008-04-07 2009-10-14 Erasmus University Medical Center Rotterdam Verbesserte Verfahren und Kits zum Erkennen von tumorspezifischen Fusionsproteinen
RU2558797C2 (ru) * 2009-10-20 2015-08-10 Нестек С.А. Способы выявления онкогенных слитых белков, основанные на анализе близкого взаимного расположения
KR20170123849A (ko) 2016-04-29 2017-11-09 주식회사유한양행 Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
WO1992021032A1 (en) * 1991-05-24 1992-11-26 The Regents Of The University Of California Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients
WO1994027698A2 (en) * 1993-05-28 1994-12-08 Baxter International Inc. Continuous centrifugation process for the separation of biologic components from heterogeneous cell populations
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US6107457A (en) * 1995-02-16 2000-08-22 Board Of Regents, The University Of Texas System Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth
US6159748A (en) * 1995-03-13 2000-12-12 Affinitech, Ltd Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
IL121659A (en) * 1996-10-25 2000-07-16 Bayer Ag Method for determining CPSA in a blood sample
CA2290656C (en) * 1997-05-20 2008-01-15 Erasmus Universiteit Rotterdam Recognition of tumour-specific gene products in cancer
US6686165B2 (en) * 1997-05-20 2004-02-03 Erasmus Universiteit Rotterdam Recognition of tumor-specific gene products in cancer
DE19856261C1 (de) * 1998-12-07 2000-03-30 Hoechst Marion Roussel De Gmbh Aß-Peptid Screening Assay
CA2411392C (en) * 2001-11-07 2012-10-16 Stemcell Technologies Inc. Tetrameric antibody complexes for blocking non-specific binding of antigens

Also Published As

Publication number Publication date
CN1836165B (zh) 2010-10-06
CN1836165A (zh) 2006-09-20
AU2004264178A1 (en) 2005-02-17
JP2007502404A (ja) 2007-02-08
EP1660888B1 (de) 2009-02-25
ATE423974T1 (de) 2009-03-15
WO2005015235A1 (en) 2005-02-17
CA2535073A1 (en) 2005-02-17
ES2323067T3 (es) 2009-07-06
DK1660888T3 (da) 2009-06-15
EP1660888A1 (de) 2006-05-31
US20060172345A1 (en) 2006-08-03
EP1507147A1 (de) 2005-02-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition