DE602004019086D1 - Mikroorganismus und verfahren zur herstellung von pravastatin - Google Patents
Mikroorganismus und verfahren zur herstellung von pravastatinInfo
- Publication number
- DE602004019086D1 DE602004019086D1 DE602004019086T DE602004019086T DE602004019086D1 DE 602004019086 D1 DE602004019086 D1 DE 602004019086D1 DE 602004019086 T DE602004019086 T DE 602004019086T DE 602004019086 T DE602004019086 T DE 602004019086T DE 602004019086 D1 DE602004019086 D1 DE 602004019086D1
- Authority
- DE
- Germany
- Prior art keywords
- microorganism
- preparing pravastatin
- pravastatin
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
- 229960002965 pravastatin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/365—Nocardia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031414753A CN1244688C (zh) | 2003-07-09 | 2003-07-09 | 生产普伐他汀钠的微生物和方法 |
| PCT/CN2004/000699 WO2005005618A1 (fr) | 2003-07-09 | 2004-06-28 | Micro-organisme et procede pour la preparation de pravastatine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004019086D1 true DE602004019086D1 (de) | 2009-03-05 |
Family
ID=33752648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004019086T Expired - Lifetime DE602004019086D1 (de) | 2003-07-09 | 2004-06-28 | Mikroorganismus und verfahren zur herstellung von pravastatin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7582464B2 (de) |
| EP (1) | EP1642964B1 (de) |
| JP (1) | JP4263741B2 (de) |
| CN (1) | CN1244688C (de) |
| DE (1) | DE602004019086D1 (de) |
| WO (1) | WO2005005618A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2029750T3 (da) * | 2006-06-22 | 2011-10-17 | Dsm Ip Assets Bv | Fremstilling af pravastatin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3682557D1 (de) | 1985-09-13 | 1992-01-02 | Sankyo Co | Hydroxy-ml-236b-derivate, deren herstellung und anwendung. |
| US5942423A (en) | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| ZA969974B (en) | 1995-11-29 | 1997-06-17 | Sankyo Co | Actinomycete promoter |
| KR100210482B1 (ko) * | 1997-04-10 | 1999-07-15 | 김종인 | 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 |
| JP3645491B2 (ja) | 1999-02-03 | 2005-05-11 | インスティテュート フォー ドラッグ リサーチ リミティド | プラバスタチンの微生物学的製法 |
| HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
-
2003
- 2003-07-09 CN CNB031414753A patent/CN1244688C/zh not_active Expired - Lifetime
-
2004
- 2004-06-28 EP EP04738297A patent/EP1642964B1/de not_active Expired - Fee Related
- 2004-06-28 JP JP2006517934A patent/JP4263741B2/ja not_active Expired - Lifetime
- 2004-06-28 DE DE602004019086T patent/DE602004019086D1/de not_active Expired - Lifetime
- 2004-06-28 WO PCT/CN2004/000699 patent/WO2005005618A1/zh active Application Filing
-
2006
- 2006-01-06 US US11/328,494 patent/US7582464B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1642964A1 (de) | 2006-04-05 |
| EP1642964B1 (de) | 2009-01-14 |
| CN1244688C (zh) | 2006-03-08 |
| WO2005005618A1 (fr) | 2005-01-20 |
| EP1642964A4 (de) | 2007-04-25 |
| JP4263741B2 (ja) | 2009-05-13 |
| JP2007508805A (ja) | 2007-04-12 |
| US7582464B2 (en) | 2009-09-01 |
| US20060166340A1 (en) | 2006-07-27 |
| CN1566328A (zh) | 2005-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |