DE602004017151D1 - Gonadotropin releasing hormone analoga konjugate mit steroid hormonen - Google Patents

Gonadotropin releasing hormone analoga konjugate mit steroid hormonen

Info

Publication number
DE602004017151D1
DE602004017151D1 DE602004017151T DE602004017151T DE602004017151D1 DE 602004017151 D1 DE602004017151 D1 DE 602004017151D1 DE 602004017151 T DE602004017151 T DE 602004017151T DE 602004017151 T DE602004017151 T DE 602004017151T DE 602004017151 D1 DE602004017151 D1 DE 602004017151D1
Authority
DE
Germany
Prior art keywords
konjugate
hormonen
analoga
steroid
mit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004017151T
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of DE602004017151D1 publication Critical patent/DE602004017151D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE602004017151T 2003-04-04 2004-04-05 Gonadotropin releasing hormone analoga konjugate mit steroid hormonen Expired - Lifetime DE602004017151D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0307777.3A GB0307777D0 (en) 2003-04-04 2003-04-04 Conjugate compounds
PCT/GB2004/001478 WO2004087215A1 (en) 2003-04-04 2004-04-05 Gonadotropin releasing hormone analogues conjugates with steroid hormones

Publications (1)

Publication Number Publication Date
DE602004017151D1 true DE602004017151D1 (en) 2008-11-27

Family

ID=9956164

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004017151T Expired - Lifetime DE602004017151D1 (en) 2003-04-04 2004-04-05 Gonadotropin releasing hormone analoga konjugate mit steroid hormonen

Country Status (8)

Country Link
US (1) US7700559B2 (de)
EP (1) EP1613357B1 (de)
JP (1) JP4614943B2 (de)
AT (1) ATE411052T1 (de)
DE (1) DE602004017151D1 (de)
ES (1) ES2318284T3 (de)
GB (1) GB0307777D0 (de)
WO (1) WO2004087215A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005020359D1 (de) 2005-01-14 2010-05-12 Camurus Ab Topische bioadhäsive formulierungen
US9649382B2 (en) 2005-01-14 2017-05-16 Camurus Ab Topical bioadhesive formulations
CA2594710C (en) * 2005-01-14 2011-01-25 Camurus Ab Topical bioadhesive formulations
DE602005026998D1 (de) 2005-01-14 2011-04-28 Camurus Ab Somatostatin-analog-formulierungen
KR101245022B1 (ko) 2005-01-21 2013-03-19 카무러스 에이비 약제학적 지질 조성물
US8546326B2 (en) 2005-06-06 2013-10-01 Camurus Ab Glp-1 analogue formulations
EP2129402A2 (de) * 2007-02-16 2009-12-09 KTB Tumorforschungsgesellschaft mbH Prodrug mit rezeptor- und antigen-target
US20080261933A1 (en) * 2007-04-23 2008-10-23 Jens Hoffmann Combination of progesterone-receptor antagonist together with a lutein-hormone-releasing hormone agonist and antagonist for use in brca mediated diseases
GB0711656D0 (en) 2007-06-15 2007-07-25 Camurus Ab Formulations
GB0716385D0 (en) 2007-08-22 2007-10-03 Camurus Ab Formulations
ES2633453T3 (es) 2008-01-24 2017-09-21 Esperance Pharmaceuticals Constructos de fusión de dominios líticos y métodos de preparación y utilización de los mismos
GB0815435D0 (en) 2008-08-22 2008-10-01 Camurus Ab Formulations
US8828938B2 (en) * 2009-04-24 2014-09-09 Polypeptide Laboratories A/S Method for the manufacture of degarelix
US10093961B2 (en) 2009-12-22 2018-10-09 Esperance Pharmaceuticals Methods for diagnosis of and predicting treatment efficacy of hormone receptor expressing tumors, cancers and neoplasias
US20150272622A1 (en) 2011-12-22 2015-10-01 Previvo Genetics, Llc Recovery and processing of human embryos formed in vivo
US9216037B2 (en) 2013-06-21 2015-12-22 Previvo Genetics, Llc Uterine lavage for embryo retrieval
US11672843B2 (en) 2012-05-25 2023-06-13 Camurus Ab Somatostatin receptor agonist formulations
JP6559066B2 (ja) 2012-10-30 2019-08-14 エスペランス ファーマシューティカルズ， インコーポレイテッド 抗体／薬剤結合体及び使用方法
EP4223298A3 (de) 2013-03-15 2023-08-16 AbbVie Inc. Zusammensetzungen zur verwendung bei der behandlung von schweren menstruationsblutungen
EP3275888B1 (de) * 2016-07-28 2019-09-25 Council of Scientific & Industrial Research Hybrid aus progesteron und kationischem lipid als antikrebsmittel und verfahren zur synthese davon
JP7184775B2 (ja) 2016-12-14 2022-12-06 パーデュー・リサーチ・ファウンデイション 黄体化ホルモン放出ホルモン受容体（ｌｈｒｈ－ｒ）コンジュゲートおよびその使用
JP2021531236A (ja) 2018-04-19 2021-11-18 アッヴィ・インコーポレイテッド 重度の月経出血を治療する方法
CN113166086A (zh) * 2018-09-05 2021-07-23 组装生物科学股份有限公司 用于治疗hbv的环状磺酰胺化合物

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3974135A (en) 1971-06-24 1976-08-10 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same
US3953416A (en) 1971-12-20 1976-04-27 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
US3843065A (en) 1972-10-13 1974-10-22 Bauer Bros Co Labyrinth seal ring for pulp refiner
US3849389A (en) 1972-10-19 1974-11-19 Lilly Co Eli Intermediates to the 5-phe analog of lh-rh
US3813382A (en) 1972-12-20 1974-05-28 American Home Prod Analogs of luteinizing hormone releasing factor substituted in position 9
US3890437A (en) 1973-10-03 1975-06-17 American Home Prod Method of inhibiting fertility in mammals using D{13 Phe{hu 2{b {13 D{13 Ala{hu 6{b {13 LRF
US3855199A (en) 1973-10-03 1974-12-17 American Home Prod P-glu-d-phe-t rp-ser-tyr-d-ala-leu-arg-pro-gly-nh2-and intermediates
US3914412A (en) 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US4072668A (en) 1973-11-06 1978-02-07 The Salk Institute For Biological Studies LH-RH Analogs
US3892723A (en) 1974-02-04 1975-07-01 American Home Prod P-Glu-Trp-Ser-Tyr-D-Pgl-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates
US3901872A (en) 1974-03-13 1975-08-26 American Home Prod P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates
US3886135A (en) 1974-04-10 1975-05-27 American Home Prod P-GLU-D-PHE-TRP-SER-TYR-D-PGL-LEU-ARG-PRO-GLY-NH{HD 2 {B and intermediates
US3896104A (en) 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates
US3915947A (en) 1974-07-11 1975-10-28 Lilly Co Eli Des-{8 His{hu 2{b ,Gly{hu 10{b {9 -D-Ala{hu 6 {b LHRH ethylamide as an inhibitor of LHRH
DE2438350C3 (de) 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3937695A (en) 1974-11-04 1976-02-10 American Home Products Corporation P-Glu-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH2 and intermediates
US3929759A (en) 1974-11-04 1975-12-30 American Home Prod P-Glu-D-Phe-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates
US4010125A (en) 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
FR2329293A1 (fr) 1975-10-29 1977-05-27 Parke Davis & Co Nouveaux nonapeptides et procedes pour leur production
US4018914A (en) 1975-11-13 1977-04-19 Abbott Laboratories Parturition inducement
US4022761A (en) 1976-01-19 1977-05-10 Parke, Davis & Company Tripeptides and methods for their production
US4022759A (en) 1976-01-19 1977-05-10 Parke, Davis & Company Tripeptides and methods for their production
US4022760A (en) 1976-01-19 1977-05-10 Parke, Davis & Company Tripeptides and methods for their production
US4034082A (en) 1976-03-01 1977-07-05 Abbott Laboratories Method to prevent reproduction in warm-blooded female animals with nonapeptides
US4075189A (en) 1976-09-15 1978-02-21 Parke, Davis & Company Hexapeptides
US4101538A (en) 1977-06-13 1978-07-18 Warner-Lambert Nonapeptides and methods for their production
US4124577A (en) 1977-06-13 1978-11-07 Warner-Lambert Nonapeptides and methods for their production
US4075192A (en) 1977-06-13 1978-02-21 Parke, Davis & Company Nonapeptides and methods for their production
US4143133A (en) 1977-10-03 1979-03-06 American Home Products Corporation Claudogenic-interceptive nonapeptides
US4124578A (en) 1978-01-03 1978-11-07 American Home Products Corporation Antiovulatory polypeptides
US4234571A (en) 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
US4292313A (en) 1980-04-15 1981-09-29 The Salk Institute For Biological Studies LRF Antagonists
US4341767A (en) 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
AU9102582A (en) 1981-12-10 1983-06-16 David Howard Coy Lh-rh antagonists
US4504414A (en) 1983-03-28 1985-03-12 Board Of Regents, The University Of Texas System Synthetic pyridyl-alanyl decapeptides having antiovulatory activity
US4677193A (en) 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
US4705778A (en) 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
WO1990009799A1 (en) * 1989-02-23 1990-09-07 Colorado State University Research Foundation GnRH ANALOGS FOR DESTROYING GONADOTROPHS
US6156731A (en) 1989-05-10 2000-12-05 G. D. Searle & Co. Polypeptide composition for oral administration
US5064939A (en) 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
AU647138B2 (en) 1990-03-16 1994-03-17 Laboratoires Serono Sa Treatment of polycystic ovarian disease
CA2112566A1 (en) 1991-07-01 1993-02-18 Graham J. Moore Non-desensitizing analogs of gnrh and other biologically active ligands
US5371070A (en) 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
SG50426A1 (en) 1993-05-20 1998-07-20 Biotech Australia Pty Ltd Lhrh antagonists
US5413990A (en) 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
US5502035A (en) 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
EP0738154A1 (de) 1993-08-06 1996-10-23 Abbott Laboratories N-terminus modifizierte lhrh analoge
TW449600B (en) 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
CA2163325A1 (en) 1994-11-21 1996-05-22 Kaneyoshi Kato Amine compounds, their production and use
UY23948A1 (es) 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd Derivados de anillos condensados de tiofeno su producción y uso.
KR0134534B1 (ko) * 1995-03-20 1998-04-21 김은영 (-)3(s)-메틸벤즈옥사진 유도체의 제조방법
GB2310660A (en) 1996-03-01 1997-09-03 Merck & Co Inc Benzoxazinone oxytocin receptor antagonists
US5756497A (en) 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
ID17260A (id) 1996-04-26 1997-12-11 Takeda Chemical Industries Ltd Turunan tieno piridina dan produksi serta gunanya
AU706818B2 (en) 1996-05-20 1999-06-24 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2000511186A (ja) 1996-05-20 2000-08-29 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモン拮抗薬
WO1997044339A1 (en) 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6500934B1 (en) 1996-07-24 2002-12-31 Michael Rush Lerner Bivalent agonists for G-protein coupled receptors
EP0882736A1 (de) 1997-06-02 1998-12-09 Laboratoire Theramex S.A. Peptidanaloge des LH-RH, ihre Verwendungen und die sie enthaltenden pharmazeutischen Zusammensetzungen
JP2001520997A (ja) 1997-10-28 2001-11-06 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
US6211224B1 (en) * 1997-10-28 2001-04-03 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999033831A1 (en) 1997-12-26 1999-07-08 Takeda Chemical Industries, Ltd. Nitrogen-containing heterocyclic compounds, their production and use
CA2317451A1 (en) 1998-02-11 1999-08-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999041252A1 (en) 1998-02-11 1999-08-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
NZ506839A (en) 1998-03-09 2003-05-30 Zealand Pharma As Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
AU4393199A (en) 1998-06-26 2000-01-17 Takeda Chemical Industries Ltd. Thienopyridine compounds, their production and use
US6191115B1 (en) 1998-08-12 2001-02-20 Abbott Laboratories C-terminus modified heptapeptide LHRH analogs
WO2000053178A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
AU2001248760A1 (en) 2000-04-13 2001-10-30 Takeda Chemical Industries Ltd. Preventives/remedies for alzheimer's disease
CA2415010C (en) 2000-07-05 2011-05-03 Yamanouchi Pharmaceutical Co., Ltd. Propane-1,3-dione derivatives useful as gnrh receptor antagonist
JP2003137814A (ja) 2001-08-10 2003-05-14 Takeda Chem Ind Ltd ＧｎＲＨアゴニストの併用剤
FR2849380A1 (fr) 2002-12-27 2004-07-02 Ernest Loumaye NOUVELLE UTILISATION D'UN AGONISTE DU GnRH

Also Published As

Publication number Publication date
US20060247177A1 (en) 2006-11-02
GB0307777D0 (en) 2003-05-07
WO2004087215A1 (en) 2004-10-14
ATE411052T1 (de) 2008-10-15
JP4614943B2 (ja) 2011-01-19
ES2318284T3 (es) 2009-05-01
EP1613357A1 (de) 2006-01-11
JP2006522085A (ja) 2006-09-28
EP1613357B1 (de) 2008-10-15
US7700559B2 (en) 2010-04-20

Similar Documents

Publication Publication Date Title
DE602004017151D1 (en) Gonadotropin releasing hormone analoga konjugate mit steroid hormonen
WO2006009734A8 (en) Gonadotropin releasing hormone receptor antagonists
HK1048269A1 (en) The use of non-oral androgenic steroids in the manufacture of medicine for improving elevated sex hormone binding globulin levels
WO2006058012A3 (en) Gonadotropin releasing hormone receptor antagonists
HK1098769A1 (en) Neutralizable epitope of hgf and neutralizing antibody binding to the same
HRP20050173A2 (en) Composition containing an androgenous 11?-halogensteroid and a progestational hormone, and male contraceptive based on said comosition
WO2005084296A3 (en) Fused tricyclic compounds as inhibitors of 17beta-hydroxysteroid dehydrogernase 3
UY27793A1 (es) Pirazolopiridinas substituidas con carbamato
WO2002092102A3 (en) Treatment of conditions relating to hormone deficiencies by administration of progestins
WO2002092004A3 (en) Use of hmg fragment as anti-inflammatory agents
WO2005077968A3 (en) 17-methylene-or 17 - spiro - cyclopropane 7 - substituted estra - 1, 3, 5 (10) - triene derivatives with anti - estrogenic activity
AU2003255820A1 (en) Derivatives of 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazole as antagonists of the gonadotropin releasing hormone (gnrh) for use in the treatment of sex hormone related conditions, such as prostatic of uterine cancer
CY1114121T1 (el) Λυοφιλοποιημενα σκευασματα fsh/lh
AU2003301129A1 (en) Steroid compositions for intraocular use
TW200612962A (en) Estriol and estetrol prodrugs
WO2003006063A3 (en) Formulation comprising fulvestrant
TR200102448T2 (tr) COPD tedavisi için kontrollu salma formülasyonu.
AU2003267551A1 (en) Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
BR0310085A (pt) Terapia de substituição de hormÈnio
WO2004105768A8 (en) Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
IL159478A0 (en) Remedies for eosinophilic diseases
AU2001275244A1 (en) Starter kit for low dose oral contraceptives
WO2004030687A8 (en) Long-acting gonadotropin-releasing hormone analogs and methods of use thereof
BR0311184A (pt) Terapia de reposição de hormÈnio
AU2002304816A1 (en) Modulation of steroid hormone uptake

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8370 Indication related to discontinuation of the patent is to be deleted