DE602004014237D1 - Herstellungsverfahren von kristallinem Losartan-Kaliumsalz - Google Patents

Herstellungsverfahren von kristallinem Losartan-Kaliumsalz

Info

Publication number
DE602004014237D1
DE602004014237D1 DE602004014237T DE602004014237T DE602004014237D1 DE 602004014237 D1 DE602004014237 D1 DE 602004014237D1 DE 602004014237 T DE602004014237 T DE 602004014237T DE 602004014237 T DE602004014237 T DE 602004014237T DE 602004014237 D1 DE602004014237 D1 DE 602004014237D1
Authority
DE
Germany
Prior art keywords
losartan potassium
production process
potassium salt
crystalline losartan
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004014237T
Other languages
English (en)
Inventor
Gabriele Razetti
Domenico Magrone
Mauro Ercoli
Pietro Allegrini
Graziano Castaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma SpA
Original Assignee
Dipharma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dipharma SpA filed Critical Dipharma SpA
Publication of DE602004014237D1 publication Critical patent/DE602004014237D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004014237T 2003-12-16 2004-11-19 Herstellungsverfahren von kristallinem Losartan-Kaliumsalz Expired - Fee Related DE602004014237D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002472A ITMI20032472A1 (it) 2003-12-16 2003-12-16 Procedimento per la preparazione di losartan potassio cristallino

Publications (1)

Publication Number Publication Date
DE602004014237D1 true DE602004014237D1 (de) 2008-07-17

Family

ID=34509471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014237T Expired - Fee Related DE602004014237D1 (de) 2003-12-16 2004-11-19 Herstellungsverfahren von kristallinem Losartan-Kaliumsalz

Country Status (7)

Country Link
US (1) US20050131040A1 (de)
EP (1) EP1544198B1 (de)
JP (1) JP2005179355A (de)
AT (1) ATE397603T1 (de)
DE (1) DE602004014237D1 (de)
ES (1) ES2306949T3 (de)
IT (1) ITMI20032472A1 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017396A1 (en) * 1993-12-23 1995-06-29 Merck & Co., Inc. Polymorphs of losartan and the process for the preparation of form ii of losartan
JP3249827B2 (ja) * 1996-10-29 2002-01-21 メルク エンド カンパニー インコーポレーテッド ロサルタンの結晶化法
WO2002094816A1 (en) * 2001-05-18 2002-11-28 Aurobindo Pharma Limited Process for the crystallization of losartan potassium
CN1612866A (zh) * 2001-11-14 2005-05-04 特瓦制药工业有限公司 无定形和结晶形的氯沙坦钾及其制备方法
WO2004066997A2 (en) * 2003-01-30 2004-08-12 Lek Pharmaceuticals D.D. Preparation of new pharmaceutically suitable salt of losartan and forms thereof with new purification and isolation methods

Also Published As

Publication number Publication date
EP1544198B1 (de) 2008-06-04
US20050131040A1 (en) 2005-06-16
ATE397603T1 (de) 2008-06-15
EP1544198A1 (de) 2005-06-22
ITMI20032472A1 (it) 2005-06-17
JP2005179355A (ja) 2005-07-07
ES2306949T3 (es) 2008-11-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee