DE602004008083D1 - Verstärkung der aktivität und/oder wirkdauer von ausgewählten entzündungshemmenden steroiden - Google Patents
Verstärkung der aktivität und/oder wirkdauer von ausgewählten entzündungshemmenden steroidenInfo
- Publication number
- DE602004008083D1 DE602004008083D1 DE602004008083T DE602004008083T DE602004008083D1 DE 602004008083 D1 DE602004008083 D1 DE 602004008083D1 DE 602004008083 T DE602004008083 T DE 602004008083T DE 602004008083 T DE602004008083 T DE 602004008083T DE 602004008083 D1 DE602004008083 D1 DE 602004008083D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- duration
- inflammatory steroids
- activity
- reinforcement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title 1
- 230000002787 reinforcement Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47949703P | 2003-06-19 | 2003-06-19 | |
| US479497P | 2003-06-19 | ||
| PCT/US2004/019368 WO2004112800A1 (en) | 2003-06-19 | 2004-06-17 | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004008083D1 true DE602004008083D1 (de) | 2007-09-20 |
| DE602004008083T2 DE602004008083T2 (de) | 2008-04-24 |
Family
ID=33539182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004008083T Expired - Lifetime DE602004008083T2 (de) | 2003-06-19 | 2004-06-17 | Verstärkung der aktivität und/oder wirkdauer von ausgewählten entzündungshemmenden steroiden |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7419971B2 (de) |
| EP (1) | EP1658083B1 (de) |
| AT (1) | ATE369138T1 (de) |
| CA (1) | CA2558941C (de) |
| DE (1) | DE602004008083T2 (de) |
| HK (1) | HK1089691A1 (de) |
| WO (1) | WO2004112800A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799331B2 (en) * | 2005-08-04 | 2010-09-21 | Taro Pharmaceutical North America, Inc. | Oral suspension of prednisolone acetate |
| US7691811B2 (en) | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
| US7687484B2 (en) | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
| WO2008118426A1 (en) * | 2007-03-26 | 2008-10-02 | Combinatorx, Incorporated | Split dose corticosteroid therapy |
| WO2019155468A1 (en) | 2018-02-08 | 2019-08-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use |
| SG11202113211PA (en) | 2019-06-03 | 2021-12-30 | Biotheryx Inc | Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1384372A (en) | 1971-01-20 | 1975-02-19 | Glaxo Lab Ltd | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids |
| US3828080A (en) * | 1972-01-20 | 1974-08-06 | Glaxo Lab Ltd | Androstane-17beta-carboxylic acids and processes for the preparation thereof |
| GB1438940A (en) | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
| CH628355A5 (de) | 1976-02-24 | 1982-02-26 | Ciba Geigy Ag | Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze. |
| US4996335A (en) * | 1980-07-10 | 1991-02-26 | Nicholas S. Bodor | Soft steroids having anti-inflammatory activity |
| US4710495A (en) * | 1980-07-10 | 1987-12-01 | Otsuka Pharmaceutical Co., Ltd. | Soft steroids having anti-inflammatory activity |
| EP0502080A4 (en) * | 1989-11-21 | 1993-02-10 | The University Of Melbourne | Anti-inflammatory compositions and methods |
| US5981517A (en) | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
| TW503113B (en) | 1997-01-16 | 2002-09-21 | Senju Pharma Co | Aqueous suspension for nasal administration |
| KR100508227B1 (ko) | 1997-03-14 | 2006-03-23 | 센주 세이야꾸 가부시키가이샤 | 로테프레드놀에타보네이트수성현탁액 |
-
2004
- 2004-06-17 WO PCT/US2004/019368 patent/WO2004112800A1/en active IP Right Grant
- 2004-06-17 EP EP04755494A patent/EP1658083B1/de not_active Expired - Lifetime
- 2004-06-17 DE DE602004008083T patent/DE602004008083T2/de not_active Expired - Lifetime
- 2004-06-17 US US10/868,955 patent/US7419971B2/en active Active
- 2004-06-17 AT AT04755494T patent/ATE369138T1/de not_active IP Right Cessation
- 2004-06-17 CA CA2558941A patent/CA2558941C/en not_active Expired - Fee Related
-
2006
- 2006-10-11 HK HK06111152A patent/HK1089691A1/xx not_active IP Right Cessation
-
2008
- 2008-06-26 US US12/146,747 patent/US7776846B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004008083T2 (de) | 2008-04-24 |
| US20050020551A1 (en) | 2005-01-27 |
| US20080261930A1 (en) | 2008-10-23 |
| CA2558941C (en) | 2012-05-15 |
| WO2004112800A1 (en) | 2004-12-29 |
| EP1658083B1 (de) | 2007-08-08 |
| US7776846B2 (en) | 2010-08-17 |
| ATE369138T1 (de) | 2007-08-15 |
| CA2558941A1 (en) | 2004-12-29 |
| HK1089691A1 (en) | 2006-12-08 |
| US7419971B2 (en) | 2008-09-02 |
| EP1658083A1 (de) | 2006-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |