DE60129933D1 - Verfahren zum screening - Google Patents

Verfahren zum screening

Info

Publication number
DE60129933D1
DE60129933D1 DE60129933T DE60129933T DE60129933D1 DE 60129933 D1 DE60129933 D1 DE 60129933D1 DE 60129933 T DE60129933 T DE 60129933T DE 60129933 T DE60129933 T DE 60129933T DE 60129933 D1 DE60129933 D1 DE 60129933D1
Authority
DE
Germany
Prior art keywords
salt
tgr
screening
neuromedin
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60129933T
Other languages
English (en)
Other versions
DE60129933T2 (de
Inventor
Shuji Hinuma
Yasushi Shintani
Masaki Hosoya
Ryo Fujii
Takeo Moriya
Hideki Matsui
Shoichi Okubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of DE60129933D1 publication Critical patent/DE60129933D1/de
Application granted granted Critical
Publication of DE60129933T2 publication Critical patent/DE60129933T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Holo Graphy (AREA)
DE60129933T 2000-02-04 2001-02-02 Verfahren zum screening Expired - Lifetime DE60129933T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2000032773 2000-02-04
JP2000032773 2000-02-04
JP2000052252 2000-02-24
JP2000052252 2000-02-24
JP2000097896 2000-03-30
JP2000097896 2000-03-30
JP2000187536 2000-06-19
JP2000187536 2000-06-19
PCT/JP2001/000746 WO2001057524A1 (fr) 2000-02-04 2001-02-02 Procede de criblage

Publications (2)

Publication Number Publication Date
DE60129933D1 true DE60129933D1 (de) 2007-09-27
DE60129933T2 DE60129933T2 (de) 2008-02-14

Family

ID=27481019

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60129933T Expired - Lifetime DE60129933T2 (de) 2000-02-04 2001-02-02 Verfahren zum screening

Country Status (10)

Country Link
US (1) US7138249B2 (de)
EP (1) EP1255109B1 (de)
KR (1) KR20020086491A (de)
CN (1) CN1397019A (de)
AT (1) ATE370411T1 (de)
AU (1) AU3222701A (de)
CA (1) CA2399052A1 (de)
DE (1) DE60129933T2 (de)
IL (1) IL150824A0 (de)
WO (1) WO2001057524A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998255B1 (en) * 1999-09-24 2006-02-14 Solvay Pharmaceuticals B.V. Human G-protein coupled receptor
US6461836B1 (en) * 1999-11-05 2002-10-08 Smithkline Beecham Corporation Molecular cloning of a 7TM receptor (AxOR34) and screening methods thereof
US7163799B2 (en) 2000-04-27 2007-01-16 Merck & Co., Inc. Neuromedin U receptor NMUR2 and nucleotides encoding it
GB0100782D0 (en) * 2001-01-11 2001-02-21 Glaxo Group Ltd Assay
EP1365246A1 (de) * 2002-05-23 2003-11-26 Bayer Ag Diagnose und Therapie von mit dem Neuromedin U2 Rezeptor assoziierten Erkrankungen
JP5317318B2 (ja) 2004-12-24 2013-10-16 武田薬品工業株式会社 新規ポリペプチドおよびその用途
US20100298234A1 (en) * 2006-08-16 2010-11-25 Naoki Kimura Cancer therapeutic agents comprising a ligand for the neuromedin u receptor 2 (fm4) molecule as an active ingredient
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801455D0 (sv) 1998-04-24 1998-04-24 Astra Pharma Inc New receptor
EP1097170A1 (de) 1998-07-13 2001-05-09 Merck & Co., Inc. Verwandte rezeptoren des wachstumshormon-sekretionsförderers und nukleinsäuren
CA2348688A1 (en) 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
US20030017528A1 (en) * 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
EP1849866B1 (de) * 1998-11-20 2008-05-21 Arena Pharmaceuticals, Inc. Menschliche, an ein G-Protein gekoppelte Rezeptor RUP3 ohne bekannte Ligand
AU1553101A (en) 1999-11-29 2001-06-12 Takeda Chemical Industries Ltd. Screening method
US7029857B1 (en) 1999-12-17 2006-04-18 H. Lundbeck A/S Processes for obtaining compounds employing SNORF72 receptors
US7163799B2 (en) 2000-04-27 2007-01-16 Merck & Co., Inc. Neuromedin U receptor NMUR2 and nucleotides encoding it

Also Published As

Publication number Publication date
AU3222701A (en) 2001-08-14
EP1255109A4 (de) 2005-03-23
US20040152136A1 (en) 2004-08-05
EP1255109A1 (de) 2002-11-06
CN1397019A (zh) 2003-02-12
IL150824A0 (en) 2003-02-12
WO2001057524A1 (fr) 2001-08-09
DE60129933T2 (de) 2008-02-14
US7138249B2 (en) 2006-11-21
CA2399052A1 (en) 2001-08-09
EP1255109B1 (de) 2007-08-15
ATE370411T1 (de) 2007-09-15
KR20020086491A (ko) 2002-11-18

Similar Documents

Publication Publication Date Title
ATA8612001A (de) Verfahren zum testen von software
DE60122131D1 (de) Verfahren zum verkleben eines fügeteils
ATE429510T1 (de) Verfahren zum nachweis von liganden
DE60203210D1 (de) Automatisches System zum Reparieren von Artikeln
DE60132243D1 (de) Verfahren zum indizieren von entitäten
DE60222206D1 (de) Verfahren zum Schneiden von elastomerischen Materialien
DE50211265D1 (de) Verfahren zum Herstellen von Zigarettenpackungen
DE60136355D1 (de) Verfahren zum entwickeln von werkzeugen
DE50104569D1 (de) Verfahren zum behandeln von tabak
DE60044618D1 (de) Verfahren zum verbinden von strickwaren
DE60129933D1 (de) Verfahren zum screening
DE602004022156D1 (de) Verfahren zum verbinden von strickwaren
DE502004008042D1 (de) Verfahren zum umformen von blechen
DE60206863D1 (de) Verfahren zum hydraulischen Transfer
DE50310109D1 (de) Verfahren zum einfärben von düngemitteln
DE112004000431T8 (de) Verfahren zum Herstellen von Ventileinstellungsanordnungen
DE60113684D1 (de) Verfahren zum dispergieren von polyacrylamiden
DE50306401D1 (de) Verfahren und vorrichtung zum dauerhaften verbinden von einander überlappenden, plattenförmigen bauteilen
DE60303359D1 (de) Verfahren zum verdichten von beuteln
DE60203614D1 (de) Verfahren zum herstellen von kunststoffbeuteln
DE50105279D1 (de) Verfahren zum Zuführen von Blechtafeln
DE60208973D1 (de) Verfahren zum Transportieren von sehr grossen Reifen
DE50105330D1 (de) Verfahren zum herstellen von flachbandkabeln
DE60130929D1 (de) Giessverfahren zum herstellen von zementgegenständen
DE60105997D1 (de) Verfahren zum einstellen der härte von fischer-tropschwachs durch mischung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition