DE60129123D1 - BIOLOGISCH AKTIVE 4H-BENZOi1,4öOXAZIN-3-ONE - Google Patents

BIOLOGISCH AKTIVE 4H-BENZOi1,4öOXAZIN-3-ONE

Info

Publication number
DE60129123D1
DE60129123D1 DE60129123T DE60129123T DE60129123D1 DE 60129123 D1 DE60129123 D1 DE 60129123D1 DE 60129123 T DE60129123 T DE 60129123T DE 60129123 T DE60129123 T DE 60129123T DE 60129123 D1 DE60129123 D1 DE 60129123D1
Authority
DE
Germany
Prior art keywords
40oxazin
benzo1
biologically active
biologically
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60129123T
Other languages
English (en)
Other versions
DE60129123T2 (de
Inventor
Thomas P Burris
Donald W Combs
Philip J Rybczynski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of DE60129123D1 publication Critical patent/DE60129123D1/de
Application granted granted Critical
Publication of DE60129123T2 publication Critical patent/DE60129123T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60129123T 2000-05-12 2001-05-11 BIOLOGISCH AKTIVE 4H-BENZOi1,4öOXAZIN-3-ONE Expired - Lifetime DE60129123T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20386000P 2000-05-12 2000-05-12
US203860P 2000-05-12
PCT/US2001/015383 WO2001087862A2 (en) 2000-05-12 2001-05-11 Biologically active 4h-benzo[1,4]oxazin-3-ones
US09/854,302 US6555536B2 (en) 2000-05-12 2001-05-11 Biologically active 4H-benzo [1,4]oxazin-3-ones
US854302 2001-05-11

Publications (2)

Publication Number Publication Date
DE60129123D1 true DE60129123D1 (de) 2007-08-09
DE60129123T2 DE60129123T2 (de) 2008-02-28

Family

ID=26898967

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60129123T Expired - Lifetime DE60129123T2 (de) 2000-05-12 2001-05-11 BIOLOGISCH AKTIVE 4H-BENZOi1,4öOXAZIN-3-ONE

Country Status (12)

Country Link
US (1) US6555536B2 (de)
EP (1) EP1280784B1 (de)
AR (1) AR033375A1 (de)
AT (1) ATE365725T1 (de)
AU (1) AU2001263083A1 (de)
CY (1) CY1106863T1 (de)
DE (1) DE60129123T2 (de)
DK (1) DK1280784T3 (de)
ES (1) ES2288957T3 (de)
MY (1) MY141659A (de)
PT (1) PT1280784E (de)
WO (1) WO2001087862A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US6908908B2 (en) * 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
WO2002100341A2 (en) * 2001-06-12 2002-12-19 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7041693B2 (en) 2002-10-04 2006-05-09 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
WO2006057448A1 (ja) * 2004-11-26 2006-06-01 Takeda Pharmaceutical Company Limited アリールアルカン酸誘導体
MX2008011022A (es) * 2006-02-28 2008-09-10 Wellstat Therapeutics Corp Compuestos para el tratamiento de trastornos metabolicos.
JP2010502719A (ja) 2006-09-08 2010-01-28 ロード アイランド ホスピタル アルコール誘発性脳疾患の治療、予防および回復

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
BR9508468A (pt) 1994-07-29 1997-11-25 Smithkline Beecham Plc Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário
JPH0912575A (ja) * 1995-06-28 1997-01-14 Sankyo Co Ltd ベンゾオキサジンおよびベンゾチアジン誘導体
US5696117A (en) * 1995-11-07 1997-12-09 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
US5707990A (en) 1996-01-30 1998-01-13 Ortho Pharmaceutical Corporation 2-substituted amino and thio alkyl benzoxazine antimicrobial agents
NZ504106A (en) 1998-05-27 2003-02-28 Dr Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US6555536B2 (en) 2003-04-29
PT1280784E (pt) 2007-09-03
ATE365725T1 (de) 2007-07-15
MY141659A (en) 2010-05-31
WO2001087862A2 (en) 2001-11-22
ES2288957T3 (es) 2008-02-01
DK1280784T3 (da) 2007-10-29
EP1280784B1 (de) 2007-06-27
AU2001263083A1 (en) 2001-11-26
AR033375A1 (es) 2003-12-17
WO2001087862A3 (en) 2002-05-30
EP1280784A2 (de) 2003-02-05
CY1106863T1 (el) 2012-09-26
DE60129123T2 (de) 2008-02-28
US20020165228A1 (en) 2002-11-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition