DE60126482D1 - Einkettige antikörper gegen eine p53 mutante - Google Patents

Einkettige antikörper gegen eine p53 mutante

Info

Publication number
DE60126482D1
DE60126482D1 DE60126482T DE60126482T DE60126482D1 DE 60126482 D1 DE60126482 D1 DE 60126482D1 DE 60126482 T DE60126482 T DE 60126482T DE 60126482 T DE60126482 T DE 60126482T DE 60126482 D1 DE60126482 D1 DE 60126482D1
Authority
DE
Germany
Prior art keywords
mutante
antibodies against
scfv
pharmaceutical compositions
epitope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60126482T
Other languages
English (en)
Other versions
DE60126482T2 (de
Inventor
Beka Solomon
Gerald Cohen
Dimitri Govorko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd filed Critical Ramot at Tel Aviv University Ltd
Publication of DE60126482D1 publication Critical patent/DE60126482D1/de
Application granted granted Critical
Publication of DE60126482T2 publication Critical patent/DE60126482T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
DE60126482T 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante Expired - Lifetime DE60126482T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US526738 2000-03-16
US09/526,738 US6630584B1 (en) 2000-03-16 2000-03-16 Single chain antibody against mutant p53
PCT/IL2001/000225 WO2001068801A2 (en) 2000-03-16 2001-03-09 Single chain antibody against mutant p53

Publications (2)

Publication Number Publication Date
DE60126482D1 true DE60126482D1 (de) 2007-03-22
DE60126482T2 DE60126482T2 (de) 2007-11-29

Family

ID=24098588

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60126482T Expired - Lifetime DE60126482T2 (de) 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante

Country Status (6)

Country Link
US (2) US6630584B1 (de)
EP (1) EP1272609B1 (de)
AT (1) ATE353335T1 (de)
AU (1) AU2001239517A1 (de)
DE (1) DE60126482T2 (de)
WO (1) WO2001068801A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53
US7799556B2 (en) * 2004-06-17 2010-09-21 George Dacai Liu System and method for antigen structure-independent detection of antigens captured on antibody arrays
US20060263837A1 (en) * 2004-06-17 2006-11-23 Liu George D Immunoassay system and method for detection of antigens
JP4991544B2 (ja) 2004-08-23 2012-08-01 イエダ リサーチ アンド デベロップメント カンパニー リミテッド ストレス応答を媒介するためのペプチド阻害剤
WO2006100681A2 (en) 2005-03-25 2006-09-28 Ramot At Tel Aviv University Ltd. Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses
NZ568762A (en) 2005-11-07 2011-11-25 Scripps Research Inst Use of an inhibitor of tissue factor signaling in the manufacture of a medcament for inhibiting or suppressing tissue factor/tissue factor VIIa signaling involving protease activated receptor 2 in a mammal
US8187601B2 (en) * 2008-07-01 2012-05-29 Aveo Pharmaceuticals, Inc. Fibroblast growth factor receptor 3 (FGFR3) binding proteins
GB2482536B (en) * 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
US20140088017A1 (en) 2011-05-23 2014-03-27 Yeda Research And Development Co., Ltd. Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
US20150329639A1 (en) 2012-12-12 2015-11-19 University Of Virginia Patent Foundation Compositions and methods for regulating erythropoiesis
EP2958584A1 (de) * 2013-02-20 2015-12-30 Yeda Research and Development Co., Ltd. Gegen mutante p53-exprimierende zellen gerichtete interferonbehandlung
EP3220953B1 (de) * 2014-11-21 2020-04-01 University of the Sciences in Philadelphia Zusammensetzungen und verfahren zur verwendung therapeutischer p53-peptide und analoge
CA2980292A1 (en) * 2015-03-23 2016-09-29 The Johns Hopkins University Hla-restricted epitopes encoded by somatically mutated genes
GB201617564D0 (en) 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies
CA3063905A1 (en) 2017-05-16 2018-11-22 The Johns Hopkins University Manabodies and methods of using
CN113528467B (zh) * 2021-06-24 2023-12-01 新乡学院 一种靶向性双展示噬菌体及其制备方法和应用
WO2023060248A1 (en) * 2021-10-08 2023-04-13 Sola Biosciences Llc Compositions and methods for the treatment of p53-mediated cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5258498A (en) * 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
CN1141059A (zh) * 1993-11-22 1997-01-22 昂尼克斯药物公司 P53-结合多肽和编码该多肽的多核苷酸
FR2755144B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Fragments d'anticorps a chaine unique anti-p53 et utilisation
US20020155114A1 (en) * 1998-08-31 2002-10-24 James D. Marks Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53

Also Published As

Publication number Publication date
WO2001068801A3 (en) 2002-02-07
WO2001068801A2 (en) 2001-09-20
EP1272609B1 (de) 2007-02-07
AU2001239517A1 (en) 2001-09-24
US7288637B2 (en) 2007-10-30
US6630584B1 (en) 2003-10-07
DE60126482T2 (de) 2007-11-29
ATE353335T1 (de) 2007-02-15
EP1272609A4 (de) 2004-12-22
EP1272609A2 (de) 2003-01-08
US20030022244A1 (en) 2003-01-30

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