DE60120356D1 - Verbesserte galactosylierung von rekombinanten proteinen - Google Patents

Verbesserte galactosylierung von rekombinanten proteinen

Info

Publication number
DE60120356D1
DE60120356D1 DE60120356T DE60120356T DE60120356D1 DE 60120356 D1 DE60120356 D1 DE 60120356D1 DE 60120356 T DE60120356 T DE 60120356T DE 60120356 T DE60120356 T DE 60120356T DE 60120356 D1 DE60120356 D1 DE 60120356D1
Authority
DE
Germany
Prior art keywords
recombinant proteins
galactosylation
improved
improved galactosylation
enhanced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60120356T
Other languages
English (en)
Other versions
DE60120356T2 (de
Inventor
Thomas Ryll
Frank S Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE60120356D1 publication Critical patent/DE60120356D1/de
Publication of DE60120356T2 publication Critical patent/DE60120356T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE60120356T 2000-02-08 2001-02-07 Verbesserte galactosylierung von rekombinanten proteinen Expired - Fee Related DE60120356T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18110800P 2000-02-08 2000-02-08
US181108P 2000-02-08
US19164100P 2000-03-23 2000-03-23
US191641P 2000-03-23
PCT/US2001/003945 WO2001059089A2 (en) 2000-02-08 2001-02-07 Improved galactosylation of recombinant glycoproteins

Publications (2)

Publication Number Publication Date
DE60120356D1 true DE60120356D1 (de) 2006-07-20
DE60120356T2 DE60120356T2 (de) 2007-06-14

Family

ID=26876894

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120356T Expired - Fee Related DE60120356T2 (de) 2000-02-08 2001-02-07 Verbesserte galactosylierung von rekombinanten proteinen

Country Status (10)

Country Link
US (2) US20030211573A1 (de)
EP (1) EP1254216B1 (de)
JP (1) JP2003521942A (de)
AT (1) ATE329018T1 (de)
AU (1) AU783973B2 (de)
CA (1) CA2399266A1 (de)
DE (1) DE60120356T2 (de)
ES (1) ES2266159T3 (de)
IL (1) IL151131A0 (de)
WO (1) WO2001059089A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1576182B2 (de) 2002-12-23 2020-01-15 Bristol-Myers Squibb Company Produktqualitätsverbesserung in säugerzellkulturverfahrenzur proteinproduktion
NZ568403A (en) * 2003-05-09 2009-10-30 Univ Duke CD20-specific antibodies and methods of employing same
BRPI0716762A2 (pt) 2006-09-13 2013-09-24 Abbott Lab melhorias da cultura celular
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
US7873748B2 (en) * 2007-11-30 2011-01-18 International Business Machines Corporation Synchronization of locally and remotely stored browser data
CA2738498A1 (en) 2008-10-20 2010-12-09 Abbott Laboratories Isolation and purification of antibodies using protein a affinity chromatography
SG195577A1 (en) 2008-10-20 2013-12-30 Abbott Lab Viral inactivation during purification of antibodies
AU2010254215A1 (en) * 2009-05-26 2011-12-01 Momenta Pharmaceuticals, Inc. Production of glycoproteins
MX2012011648A (es) 2010-04-07 2012-11-29 Momenta Pharmaceuticals Inc Glicanos de alta manosa.
WO2012125553A2 (en) 2011-03-12 2012-09-20 Momenta Pharmaceuticals, Inc. N-acetylhexosamine-containing n-glycans in glycoprotein products
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
SG11201504249XA (en) 2012-09-02 2015-07-30 Abbvie Inc Methods to control protein heterogeneity
CA2905010A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
WO2014170866A2 (en) * 2013-04-18 2014-10-23 Dr. Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased galactosylation content
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
RU2642285C1 (ru) * 2014-01-29 2018-01-24 ЭлДжи КЕМ, ЛТД. Способ получения целевого антитела с модулированным галактозилированием (варианты) и способ модулирования галактозилирования целевого антитела (варианты) путем оптимизации культуральной среды
KR101660580B1 (ko) * 2014-04-02 2016-09-28 프레스티지 바이오파마 피티이. 엘티디. 항체의 당 함량 조절을 통한 항체의 제조 방법
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3144193A (en) * 1991-11-21 1993-06-15 Board Of Trustees Of The Leland Stanford Junior University Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
WO2000029603A2 (en) * 1998-11-18 2000-05-25 Neose Technologies, Inc. Low cost manufacture of oligosaccharides
US6949372B2 (en) * 1999-03-02 2005-09-27 The Johns Hopkins University Engineering intracellular sialylation pathways
WO2001014569A2 (de) * 1999-08-20 2001-03-01 Basf Plant Science Gmbh Erhöhung des polysaccharidgehaltes in pflanzen

Also Published As

Publication number Publication date
DE60120356T2 (de) 2007-06-14
WO2001059089A2 (en) 2001-08-16
US20070111284A1 (en) 2007-05-17
AU3490301A (en) 2001-08-20
US20030211573A1 (en) 2003-11-13
CA2399266A1 (en) 2001-08-16
ES2266159T3 (es) 2007-03-01
WO2001059089A3 (en) 2002-07-04
IL151131A0 (en) 2003-04-10
JP2003521942A (ja) 2003-07-22
EP1254216A2 (de) 2002-11-06
ATE329018T1 (de) 2006-06-15
EP1254216B1 (de) 2006-06-07
AU783973B2 (en) 2006-01-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee