DE60116642D1 - Verbindungen mit cytochrom p450ra1 hemmenden aktivität - Google Patents
Verbindungen mit cytochrom p450ra1 hemmenden aktivitätInfo
- Publication number
- DE60116642D1 DE60116642D1 DE60116642T DE60116642T DE60116642D1 DE 60116642 D1 DE60116642 D1 DE 60116642D1 DE 60116642 T DE60116642 T DE 60116642T DE 60116642 T DE60116642 T DE 60116642T DE 60116642 D1 DE60116642 D1 DE 60116642D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- p450ra1
- cytochrom
- hardening activity
- hardening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US651003 | 2000-08-29 | ||
US09/651,235 US6252090B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
US651566 | 2000-08-29 | ||
US651235 | 2000-08-29 | ||
US09/651,564 US6380256B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
US09/651,003 US6303785B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
US09/651,234 US6387951B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
US09/651,001 US6291677B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
US651001 | 2000-08-29 | ||
US651004 | 2000-08-29 | ||
US651234 | 2000-08-29 | ||
US09/651,566 US6369225B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
US651564 | 2000-08-29 | ||
US09/651,004 US6369261B1 (en) | 2000-08-29 | 2000-08-29 | Compounds having activity as inhibitors of cytochrome P450RAI |
PCT/US2001/025443 WO2002018361A2 (en) | 2000-08-29 | 2001-08-14 | Compounds having activity as inhibitors of cytochrome p450rai |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60116642D1 true DE60116642D1 (de) | 2006-04-06 |
DE60116642T2 DE60116642T2 (de) | 2006-11-09 |
Family
ID=27569871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60116642T Expired - Fee Related DE60116642T2 (de) | 2000-08-29 | 2001-08-14 | Verbindungen mit cytochrom p450ra1 hemmenden aktivität |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1366036B1 (de) |
JP (1) | JP2004507531A (de) |
AT (1) | ATE315558T1 (de) |
AU (2) | AU2001286471B2 (de) |
CA (1) | CA2420869A1 (de) |
DE (1) | DE60116642T2 (de) |
ES (1) | ES2256288T3 (de) |
HK (1) | HK1059439A1 (de) |
WO (1) | WO2002018361A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
JP5082033B2 (ja) | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Lxrのモジュレーター |
US6740676B2 (en) * | 2002-03-19 | 2004-05-25 | Allergan, Inc. | 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity |
KR20050055747A (ko) | 2002-10-04 | 2005-06-13 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 염증 질환 치료용의 pgd2 수용체 길항제 |
US7504508B2 (en) | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
CA2537093C (en) | 2003-08-29 | 2013-11-12 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding s1p receptor and pharmaceutical use thereof |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
US7226951B2 (en) * | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
EP2371811B1 (de) | 2004-12-13 | 2014-10-08 | Ono Pharmaceutical Co., Ltd. | Azetidincarboxylsäurederivat und medizinische Verwendung davon |
MX2007010215A (es) | 2005-02-24 | 2007-11-07 | Millennium Pharm Inc | Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias. |
EP2643303A1 (de) * | 2010-11-24 | 2013-10-02 | Allergan, Inc. | Modulatoren von s1p-rezeptoren |
EP2910549A1 (de) | 2011-09-15 | 2015-08-26 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalenderivate als rxr-modulatoren zur behandlung von alzheimer-krankheit und krebs |
US10328040B2 (en) | 2014-01-17 | 2019-06-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic methods |
PL3204357T3 (pl) * | 2014-10-10 | 2022-04-25 | High Force Research Limited | Fluorescencyjne retinoidy syntetyczne |
US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3475305D1 (en) * | 1983-07-05 | 1988-12-29 | Pfizer | Carboxylic acid derivatives useful for inhibiting the degradation of cartilage |
JPS6323868A (ja) * | 1986-07-11 | 1988-02-01 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | アンギオテンシン2受容体遮断性イミダゾ−ル |
US5089509A (en) * | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US5015658A (en) * | 1988-06-29 | 1991-05-14 | Allergan, Inc. | Thiochroman esters of phenols and terephthallates having retinoid-like activity |
US5023341A (en) * | 1989-09-19 | 1991-06-11 | Allergan, Inc. | Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity |
US5045551A (en) * | 1989-09-19 | 1991-09-03 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5202471A (en) * | 1990-02-06 | 1993-04-13 | Allergan, Inc. | Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes having retinoid like activity |
US5134159A (en) * | 1991-03-26 | 1992-07-28 | Allergan, Inc. | 7-chromanyl esters of phenols and benzoic acids having retinoid-like activity |
US5489584A (en) * | 1994-12-29 | 1996-02-06 | Allergan, Inc. | Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
AU698527B2 (en) * | 1994-12-29 | 1998-10-29 | Allergan, Inc. | Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
-
2001
- 2001-08-14 CA CA002420869A patent/CA2420869A1/en not_active Abandoned
- 2001-08-14 AU AU2001286471A patent/AU2001286471B2/en not_active Ceased
- 2001-08-14 AT AT01965920T patent/ATE315558T1/de not_active IP Right Cessation
- 2001-08-14 AU AU8647101A patent/AU8647101A/xx active Pending
- 2001-08-14 ES ES01965920T patent/ES2256288T3/es not_active Expired - Lifetime
- 2001-08-14 EP EP01965920A patent/EP1366036B1/de not_active Expired - Lifetime
- 2001-08-14 WO PCT/US2001/025443 patent/WO2002018361A2/en active IP Right Grant
- 2001-08-14 JP JP2002523479A patent/JP2004507531A/ja active Pending
- 2001-08-14 DE DE60116642T patent/DE60116642T2/de not_active Expired - Fee Related
-
2004
- 2004-03-31 HK HK04102361A patent/HK1059439A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2002018361A3 (en) | 2003-07-31 |
AU2001286471B2 (en) | 2006-09-07 |
EP1366036B1 (de) | 2006-01-11 |
ATE315558T1 (de) | 2006-02-15 |
EP1366036A2 (de) | 2003-12-03 |
ES2256288T3 (es) | 2006-07-16 |
AU8647101A (en) | 2002-03-13 |
JP2004507531A (ja) | 2004-03-11 |
HK1059439A1 (en) | 2004-07-02 |
DE60116642T2 (de) | 2006-11-09 |
WO2002018361A2 (en) | 2002-03-07 |
CA2420869A1 (en) | 2002-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60116642D1 (de) | Verbindungen mit cytochrom p450ra1 hemmenden aktivität | |
WO2002026727A3 (en) | Methods of providing and using compounds (retinoids) having activity as inhibitors of cytochrome p450rai | |
ATE357272T1 (de) | Verwendung von phthalazin-derivaten zur behandlung neurodegenerativer krankheiten | |
ATE312635T1 (de) | Ventilanordnung | |
NO20002440D0 (no) | Hydroksam- og karboksylsyrederivater med MMP- og TNF- inhiberende aktivitet | |
ATE395052T1 (de) | Verwendung von c-kit-inhibitoren für die behandlung von typ-2-diabetes | |
ID24398A (id) | Metode untuk menghasilkan asam l-amino | |
DE60143901D1 (de) | Antisense-modulation der clusterinexpression | |
SG146682A1 (en) | Modulation of eif4e expression | |
WO2004031350A3 (en) | Modulation of forkhead box o1a expression | |
ID30237A (id) | KOMBINASI PENGHAMBAT-PENGHAMBAT FBPase DAN PEMEKA-PEMEKA INSULIN UNTUK PENGOBATAN DIABETES | |
DE50207442D1 (de) | Behandlung der akne mit lipoxygenase inhibitoren | |
ATE355075T1 (de) | Behandlung der glykogenspeicherkrankheit typ ii | |
DE60026152D1 (de) | Verwendung von stearidonsäure zur herstellung eines arzneimittels für die behandlung oder vorbeugung von krebs | |
DE60322121D1 (de) | Zusammensetzung zur verabreichung von eisen für die behandlung des unruhigen beinsyndroms | |
DK1123414T3 (da) | Antisense-modulering af integrin alpha 4.ekspression | |
IS2254B (is) | Meðhöndlun á risaeitlingasarkmeini með tálmum viðeitilfrumueiturslóðinni | |
DE60142899D1 (de) | Verbindungen für den transfer von oligonukleotiden | |
DE60111620D1 (de) | Aktiviertes protein c zur behandlung von pankreatitis | |
ATE427745T1 (de) | Zusammensetzungen und verfahren zur erhíhung der compliance mit therapien unter verwendung von aldehyddehydrogenase-hemmern und zur behandlung von alkoholsmus | |
ATE322244T1 (de) | Verwendung von polyaminosäurederivaten zur behandlung von seborrhoe und verwandten hautstörungen | |
NO955258L (no) | Medisinsk anvendelse av enzymer | |
DK1438034T3 (da) | Anvendelse af -phenyl-3-dimethylaminiopropanforbindelser til behandling af urininkontinens | |
DE50111407D1 (de) | Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen | |
HUP0103660A2 (hu) | Mikróbaeredetű hialuronsavbontó enzimet tartalmazó gyógyászati készítmény |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |