DE60106942D1 - S-nitrosylierungsverfahren mit hoher ausbeute - Google Patents

S-nitrosylierungsverfahren mit hoher ausbeute

Info

Publication number
DE60106942D1
DE60106942D1 DE60106942T DE60106942T DE60106942D1 DE 60106942 D1 DE60106942 D1 DE 60106942D1 DE 60106942 T DE60106942 T DE 60106942T DE 60106942 T DE60106942 T DE 60106942T DE 60106942 D1 DE60106942 D1 DE 60106942D1
Authority
DE
Germany
Prior art keywords
nitrosylation
high yield
yield
nitrosylation method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106942T
Other languages
English (en)
Other versions
DE60106942T2 (de
Inventor
A Herrmann
David Knapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of DE60106942D1 publication Critical patent/DE60106942D1/de
Application granted granted Critical
Publication of DE60106942T2 publication Critical patent/DE60106942T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
DE60106942T 2000-08-24 2001-08-21 S-nitrosylierungsverfahren mit hoher ausbeute Expired - Lifetime DE60106942T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/645,171 US6417347B1 (en) 2000-08-24 2000-08-24 High yield S-nitrosylation process
US645171 2000-08-24
PCT/US2001/026113 WO2002016320A2 (en) 2000-08-24 2001-08-21 High yield s-nitrosylation process

Publications (2)

Publication Number Publication Date
DE60106942D1 true DE60106942D1 (de) 2004-12-09
DE60106942T2 DE60106942T2 (de) 2005-10-27

Family

ID=24587901

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106942T Expired - Lifetime DE60106942T2 (de) 2000-08-24 2001-08-21 S-nitrosylierungsverfahren mit hoher ausbeute

Country Status (7)

Country Link
US (4) US6417347B1 (de)
EP (1) EP1311479B1 (de)
JP (1) JP2004506785A (de)
AU (1) AU2001286588A1 (de)
CA (1) CA2432321A1 (de)
DE (1) DE60106942T2 (de)
WO (1) WO2002016320A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
GB2386900B (en) * 2002-03-25 2006-11-01 Johnson & Johnson Medical Ltd Use in wound dressings of chemically modified polysaccharides
JP2006516534A (ja) * 2002-09-11 2006-07-06 フレセニウス・カビ・ドイッチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｈａｓ化ポリペプチド、特にｈａｓ化エリスロポエチン
JP2004188969A (ja) * 2002-11-27 2004-07-08 Canon Inc 記録方法および記録装置
US7608344B2 (en) * 2003-07-30 2009-10-27 Corning Incorporated Metal honeycomb substrates for chemical and thermal applications
US20080274948A1 (en) * 2003-08-08 2008-11-06 Fresenius Kabi Deutschland Gmbh Conjugates of Hydroxyalkyl Starch and G-Csf
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
US7682012B2 (en) * 2003-12-29 2010-03-23 E. I. Du Pont De Nemours And Company Inkjet printing method and apparatus
EP2279752A3 (de) * 2004-03-11 2011-08-24 Fresenius Kabi Deutschland GmbH Konjugate von hydroxyalkylstärke und einem protein hergestellt durch native chemische ligation
EP2336192A1 (de) * 2004-03-11 2011-06-22 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt.
WO2006094810A2 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
WO2008031182A1 (en) * 2006-09-14 2008-03-20 Cristália Produtos Químicos Farmacêuticos Ltda. Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions
US20090311292A1 (en) * 2006-09-14 2009-12-17 Cristalia Produtos Quimicos Farmaceuticos Ltda. Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions
EP2070950A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern
WO2009132227A1 (en) 2008-04-24 2009-10-29 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
JP2011518837A (ja) 2008-04-24 2011-06-30 メドトロニック，インコーポレイテッド 再水和可能なチオール化多糖粒子およびスポンジ
EP2291448B1 (de) 2008-04-24 2017-01-04 Medtronic, Inc Rehydratisierbare polysaccharidteilchen und schwamm
CN102883715B (zh) 2008-04-24 2014-11-12 麦德托尼克公司 包含壳聚糖的保护性组合物
EP2591009A1 (de) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Stickoxidfreisetzende hydroxyalkylstärkederivate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5025001A (en) 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5380758A (en) 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5385937A (en) 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
DK1023905T3 (da) 1991-11-14 2005-05-30 Brigham & Womens Hospital Farmaceutisk præparat indeholdende S-nitroso-immunoglobuliner og anvendelse deraf
US5583101A (en) 1994-07-15 1996-12-10 Harvard College Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5612314A (en) 1995-04-21 1997-03-18 Brigham & Women's Hospital Nitrosylated neuropeptides
US5770645A (en) 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US6057367A (en) 1996-08-30 2000-05-02 Duke University Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses

Also Published As

Publication number Publication date
US6762282B2 (en) 2004-07-13
WO2002016320A3 (en) 2002-06-13
US20030208036A1 (en) 2003-11-06
WO2002016320A2 (en) 2002-02-28
CA2432321A1 (en) 2002-02-28
US6417347B1 (en) 2002-07-09
AU2001286588A1 (en) 2002-03-04
EP1311479B1 (de) 2004-11-03
JP2004506785A (ja) 2004-03-04
US7488794B2 (en) 2009-02-10
EP1311479A2 (de) 2003-05-21
US20020062020A1 (en) 2002-05-23
US20050038235A1 (en) 2005-02-17
DE60106942T2 (de) 2005-10-27

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Legal Events

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