DE60034888D1 - N-substituierte l-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation - Google Patents

N-substituierte l-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation

Info

Publication number
DE60034888D1
DE60034888D1 DE60034888T DE60034888T DE60034888D1 DE 60034888 D1 DE60034888 D1 DE 60034888D1 DE 60034888 T DE60034888 T DE 60034888T DE 60034888 T DE60034888 T DE 60034888T DE 60034888 D1 DE60034888 D1 DE 60034888D1
Authority
DE
Germany
Prior art keywords
peptide
beta
strand
substituted
nalpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034888T
Other languages
English (en)
Inventor
Kelvin Stott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senexis Ltd
Original Assignee
Senexis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senexis Ltd filed Critical Senexis Ltd
Application granted granted Critical
Publication of DE60034888D1 publication Critical patent/DE60034888D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60034888T 1999-07-28 2000-07-28 N-substituierte l-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation Expired - Lifetime DE60034888D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9917724.8A GB9917724D0 (en) 1999-07-28 1999-07-28 Peptides
PCT/GB2000/002901 WO2001007473A1 (en) 1999-07-28 2000-07-28 Peptides containing n-substituted l-amino acids for preventing beta-strand association

Publications (1)

Publication Number Publication Date
DE60034888D1 true DE60034888D1 (de) 2007-06-28

Family

ID=10858096

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034888T Expired - Lifetime DE60034888D1 (de) 1999-07-28 2000-07-28 N-substituierte l-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation

Country Status (10)

Country Link
US (1) US7125838B1 (de)
EP (1) EP1203019B1 (de)
JP (1) JP2003505469A (de)
AT (1) ATE362487T1 (de)
AU (1) AU766992B2 (de)
CA (1) CA2378779A1 (de)
DE (1) DE60034888D1 (de)
GB (1) GB9917724D0 (de)
NZ (1) NZ516441A (de)
WO (1) WO2001007473A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4235544B2 (ja) 2001-05-31 2009-03-11 アドライフ インコーポレーティッド 欠陥折畳み蛋白質センサー方法
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
WO2004005336A2 (en) * 2002-07-08 2004-01-15 Applied Research Systems Ars Holding N.V. β-SHEET BREAKING PEPTIDES
CA2522460A1 (en) * 2003-04-30 2004-11-11 Applied Research Systems Ars Holding N.V. Beta-amyloid inhibitors and use thereof
WO2006088823A2 (en) * 2005-02-15 2006-08-24 Adlyfe, Inc. Method for detecting misfolded proteins and prions
TWI515007B (zh) 2006-01-05 2016-01-01 美國猶他大學研究基金會 改善以神經系統為標的之藥劑之性質之方法及組合物
WO2008013859A2 (en) * 2006-07-28 2008-01-31 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
US9364449B2 (en) 2010-06-09 2016-06-14 New York University Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same
CN103517712A (zh) 2010-12-15 2014-01-15 神经佐剂股份有限公司 神经肽类似物、组合物和治疗疼痛的方法
WO2013054110A2 (en) * 2011-10-10 2013-04-18 University Of Lancaster Compositions for binding to amyloid proteins
CN114630584A (zh) * 2019-11-07 2022-06-14 纽崔西亚公司 具有致耐受性肽的深度乳清蛋白水解产物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2214247C (en) * 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
AU1072897A (en) * 1995-12-12 1997-07-03 Karolinska Innovations Ab Peptide binding the klvff-sequence of amyloid beta
US6034211A (en) * 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien

Also Published As

Publication number Publication date
EP1203019A1 (de) 2002-05-08
JP2003505469A (ja) 2003-02-12
AU766992B2 (en) 2003-10-30
US7125838B1 (en) 2006-10-24
EP1203019B1 (de) 2007-05-16
AU6173700A (en) 2001-02-13
ATE362487T1 (de) 2007-06-15
GB9917724D0 (en) 1999-09-29
CA2378779A1 (en) 2001-02-01
NZ516441A (en) 2003-11-28
WO2001007473A1 (en) 2001-02-01

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Legal Events

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