DE60031686T2 - Pyrazinone, diese verbindungen enthaltende zusammenstellungen - Google Patents
Pyrazinone, diese verbindungen enthaltende zusammenstellungen Download PDFInfo
- Publication number
- DE60031686T2 DE60031686T2 DE60031686T DE60031686T DE60031686T2 DE 60031686 T2 DE60031686 T2 DE 60031686T2 DE 60031686 T DE60031686 T DE 60031686T DE 60031686 T DE60031686 T DE 60031686T DE 60031686 T2 DE60031686 T2 DE 60031686T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- aryl
- het
- halogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 *C(C(NC(CC(O)=O)C(*)=O)=*)(N(C(*)=C(*)N=C1NO)C1=O)O Chemical compound *C(C(NC(CC(O)=O)C(*)=O)=*)(N(C(*)=C(*)N=C1NO)C1=O)O 0.000 description 1
- IESCTEDUMKXVDT-UHFFFAOYSA-N CCC(C(NCC(CSCc1ccccc1)=O)=O)N(C=CN=C1NCCCN(CCC2)C2=O)C1=O Chemical compound CCC(C(NCC(CSCc1ccccc1)=O)=O)N(C=CN=C1NCCCN(CCC2)C2=O)C1=O IESCTEDUMKXVDT-UHFFFAOYSA-N 0.000 description 1
- ASJBVJYXHWFKJN-NSHDSACASA-N CC[C@@H](C(O)=O)N(C=CN=C1NCCCN(CCC2)C2=O)C1=O Chemical compound CC[C@@H](C(O)=O)N(C=CN=C1NCCCN(CCC2)C2=O)C1=O ASJBVJYXHWFKJN-NSHDSACASA-N 0.000 description 1
- FSGQCXRZYRRALZ-ZDUSSCGKSA-N CC[C@@H](C(OCC)=O)N(C=CN=C1NCCCN(CCC2)C2=O)C1=O Chemical compound CC[C@@H](C(OCC)=O)N(C=CN=C1NCCCN(CCC2)C2=O)C1=O FSGQCXRZYRRALZ-ZDUSSCGKSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14446699P | 1999-07-19 | 1999-07-19 | |
| US144466P | 1999-07-19 | ||
| US17061499P | 1999-12-14 | 1999-12-14 | |
| US170614P | 1999-12-14 | ||
| PCT/CA2000/000833 WO2001005772A1 (en) | 1999-07-19 | 2000-07-17 | Pyrazinones, compositions containing such compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60031686D1 DE60031686D1 (de) | 2006-12-14 |
| DE60031686T2 true DE60031686T2 (de) | 2007-08-30 |
Family
ID=26842025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60031686T Expired - Lifetime DE60031686T2 (de) | 1999-07-19 | 2000-07-17 | Pyrazinone, diese verbindungen enthaltende zusammenstellungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6444811B1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1202976B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4749640B2 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE344249T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU773317B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2378834C (cg-RX-API-DMAC10.html) |
| DE (1) | DE60031686T2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2274795T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2001005772A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE344249T1 (de) * | 1999-07-19 | 2006-11-15 | Merck Frosst Canada Ltd | Pyrazinone, diese verbindungen enthaltende zusammenstellungen |
| US20020155172A1 (en) * | 2000-04-07 | 2002-10-24 | Junying Yuan | Methods and compounds for decreasing cell toxicity or death |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| AU2002246065A1 (en) * | 2001-01-26 | 2002-08-06 | Evotec Oai Ag | Methods and means for detecting enzymatic cleavage and linkage reactions |
| FR2827288B1 (fr) * | 2001-07-12 | 2003-10-31 | Servier Lab | Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1485107A1 (en) | 2002-02-11 | 2004-12-15 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
| EP1499898A2 (en) * | 2002-04-19 | 2005-01-26 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
| CA2526467C (en) | 2003-05-20 | 2015-03-03 | Kagutech Ltd. | Digital backplane recursive feedback control |
| AU2005223767B2 (en) * | 2004-03-12 | 2011-12-01 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
| CN1980658A (zh) | 2004-05-27 | 2007-06-13 | 沃泰克斯药物股份有限公司 | 治疗自身炎性疾病的ice抑制剂 |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
| KR20080042286A (ko) * | 2006-11-09 | 2008-05-15 | 주식회사 엘지생명과학 | 피리다지논 구조를 포함하는 캐스파제 저해제 |
| MY148484A (en) | 2007-08-03 | 2013-04-30 | Sanofi Aventis | Caspase imaging probes |
| EP2262783A2 (en) * | 2008-02-21 | 2010-12-22 | Sanofi-Aventis | Covalently binding imaging probes |
| JP6006908B2 (ja) | 2010-11-05 | 2016-10-12 | ブランダイス ユニバーシティＢｒａｎｄｅｉｓ Ｕｎｉｖｅｒｓｉｔｙ | Ｉｃｅ阻害化合物およびその使用 |
| CN109180690A (zh) * | 2018-10-15 | 2019-01-11 | 烟台显华化工科技有限公司 | 一类用作蓝色荧光材料的氮杂芳香化合物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| PL329441A1 (en) * | 1996-04-23 | 1999-03-29 | Merck & Co Inc | Pyrasinone-type thrombin inhibitors |
| US5981546A (en) * | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
| JP2002511052A (ja) | 1996-08-29 | 2002-04-09 | メルク エンド カンパニー インコーポレーテッド | インテグリンアンタゴニスト |
| BR9712000A (pt) * | 1996-09-06 | 1999-08-24 | Nippon Kayaku Kk | Derivados de acetamida sais dos mesmos composi-Æo farmac-utica inibidores de protease de quimase de desgranula-Æo de mastÄcitos ou de libera-Æo de histamina de mastÄcitos e de ativa-Æo de eosinÄfilo ou de libera-Æo de oxig-nio ativo de eosinÄfilo e processo para produzir os dervados de acetamida |
| AU728006B2 (en) | 1997-03-24 | 2001-01-04 | Merck & Co., Inc. | Thrombin inhibitors |
| US5866573A (en) | 1997-04-21 | 1999-02-02 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| EP1017393A4 (en) | 1997-09-05 | 2002-01-23 | Merck & Co Inc | PYRAZINONE THROMBINE INHIBITORS |
| ATE344249T1 (de) * | 1999-07-19 | 2006-11-15 | Merck Frosst Canada Ltd | Pyrazinone, diese verbindungen enthaltende zusammenstellungen |
-
2000
- 2000-07-17 AT AT00947711T patent/ATE344249T1/de not_active IP Right Cessation
- 2000-07-17 EP EP00947711A patent/EP1202976B1/en not_active Expired - Lifetime
- 2000-07-17 DE DE60031686T patent/DE60031686T2/de not_active Expired - Lifetime
- 2000-07-17 JP JP2001511433A patent/JP4749640B2/ja not_active Expired - Lifetime
- 2000-07-17 ES ES00947711T patent/ES2274795T3/es not_active Expired - Lifetime
- 2000-07-17 CA CA002378834A patent/CA2378834C/en not_active Expired - Lifetime
- 2000-07-17 WO PCT/CA2000/000833 patent/WO2001005772A1/en not_active Ceased
- 2000-07-17 AU AU61432/00A patent/AU773317B2/en not_active Expired
- 2000-07-19 US US09/618,875 patent/US6444811B1/en not_active Expired - Lifetime
-
2002
- 2002-07-25 US US10/202,817 patent/US6699856B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60031686D1 (de) | 2006-12-14 |
| ES2274795T3 (es) | 2007-06-01 |
| WO2001005772A1 (en) | 2001-01-25 |
| JP2003505378A (ja) | 2003-02-12 |
| AU773317B2 (en) | 2004-05-20 |
| JP4749640B2 (ja) | 2011-08-17 |
| CA2378834C (en) | 2009-07-07 |
| EP1202976B1 (en) | 2006-11-02 |
| CA2378834A1 (en) | 2001-01-25 |
| ATE344249T1 (de) | 2006-11-15 |
| US20030236402A1 (en) | 2003-12-25 |
| EP1202976A1 (en) | 2002-05-08 |
| US6444811B1 (en) | 2002-09-03 |
| AU6143200A (en) | 2001-02-05 |
| US6699856B2 (en) | 2004-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3130583B1 (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| DE69404324T2 (de) | Matrix metallprotease inhibitoren | |
| EP2797892B1 (de) | Pyridinonderivate als gewebetransglutaminaseinhibitoren | |
| DE4134467A1 (de) | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung | |
| DE69833774T2 (de) | Prostaglandin endoperoxyde h synthase biosynthese inhibitoren | |
| DE60030768T2 (de) | Nitrilderivate als cathepsin k hemmer | |
| EP2751086A1 (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| DE60210612T2 (de) | N-formylhydroxylamin verbindungen als inhibitoren von pdf | |
| US6699856B2 (en) | Pyrazinones, compositions containing such compounds and methods of use | |
| DE69405572T2 (de) | Matrix-metalloprotease inhibitoren | |
| JP2002539193A (ja) | カスパーゼ−３阻害薬としてのγ−ケト酸ジペプチド類 | |
| EP3126339A1 (de) | 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung | |
| JP2002531464A (ja) | カスパーゼ−３阻害薬としてのγ−ケト酸テトラペプチド類 | |
| US6525025B2 (en) | Gamma-ketoacid dipeptides as inhibitors of caspase-3 | |
| DE102008052013A1 (de) | 4-(4-Cyano-2-thioaryl)-dihydropyrimidinone und ihre Verwendung | |
| US20030045478A1 (en) | Gamma-ketoacid dipeptide derivatives as inhibitors of caspase-3 | |
| DE3432307A1 (de) | Aminosaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen | |
| EP2558462B1 (de) | Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren | |
| DE60011473T2 (de) | Diazepinecarboxamidderivate, verfahren zu ihrer herstellung ,ihre verwendung als arzneimittel, pharmazeutische zubereitungen und ihre verwendung | |
| DE4036130A1 (de) | Neue peptidderivate, die als bakterienkollagenase-inhibitoren verwendbar sind, und sie enthaltende pharmazeutische zusammensetzung | |
| HK1233253B (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| HK1233253A1 (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |