DE60029591D1 - Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen - Google Patents

Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen

Info

Publication number
DE60029591D1
DE60029591D1 DE60029591T DE60029591T DE60029591D1 DE 60029591 D1 DE60029591 D1 DE 60029591D1 DE 60029591 T DE60029591 T DE 60029591T DE 60029591 T DE60029591 T DE 60029591T DE 60029591 D1 DE60029591 D1 DE 60029591D1
Authority
DE
Germany
Prior art keywords
cyclooxygenase
pain
treatment
linolic acid
mediated inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60029591T
Other languages
English (en)
Other versions
DE60029591T2 (de
Inventor
E Cook
D Whigham
W Pariza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE60029591D1 publication Critical patent/DE60029591D1/de
Publication of DE60029591T2 publication Critical patent/DE60029591T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60029591T 1999-07-20 2000-03-24 Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen Expired - Lifetime DE60029591T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US357268 1999-07-20
US09/357,268 US6077868A (en) 1999-07-20 1999-07-20 Selective inhibition of cyclooxygenase-2
PCT/US2000/007824 WO2001005395A1 (en) 1999-07-20 2000-03-24 Selective inhibition of cyclooxygenase-2

Publications (2)

Publication Number Publication Date
DE60029591D1 true DE60029591D1 (de) 2006-09-07
DE60029591T2 DE60029591T2 (de) 2007-08-09

Family

ID=23404937

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60029591T Expired - Lifetime DE60029591T2 (de) 1999-07-20 2000-03-24 Konjugierte linolensäure zur behandlung von cyclooxygenase-2 vermittelten entzündungen und schmerzen

Country Status (8)

Country Link
US (1) US6077868A (de)
EP (1) EP1196161B1 (de)
AT (1) ATE333874T1 (de)
AU (1) AU3772000A (de)
CA (1) CA2379649C (de)
DE (1) DE60029591T2 (de)
ES (1) ES2269122T3 (de)
WO (1) WO2001005395A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
WO2001003688A2 (en) * 1999-07-09 2001-01-18 Pharmacia Corporation Treatment of cyclooxygenase-2 mediated disorders using conjugated fatty acid compounds
EP1097708B1 (de) * 1999-11-02 2003-09-17 Loders Croklaan B.V. Verwendung von trans-trans-Isomeren von konjugierter Linolsäure
ATE283048T1 (de) * 1999-12-08 2004-12-15 Pharmacia Corp Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7695736B2 (en) 2001-04-03 2010-04-13 Pfizer Inc. Reconstitutable parenteral composition
US7365099B2 (en) 2001-05-31 2008-04-29 Wisconsin Alumni Research Foundation Animal body fat control
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
KR20090118994A (ko) 2002-12-13 2009-11-18 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
US20040220155A1 (en) * 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
WO2005009342A2 (en) * 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050014832A1 (en) * 2003-07-16 2005-01-20 Lc Usa Llc Treatment
DE10332712A1 (de) * 2003-07-18 2005-02-10 Cognis Deutschland Gmbh & Co. Kg Verwendung von c9,t11-Isomeren der konjugierten Linolsäure
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
WO2005023189A2 (en) * 2003-09-03 2005-03-17 Pharmacia Corporation Method of cox-2 selective inhibitor and nitric oxide-donating agent
US20050154059A1 (en) * 2004-01-13 2005-07-14 Cook Mark E. Method of treating type III hypersensitive reaction-related diseases and conditions by using conjugated linoleic acid
EP1708718A1 (de) 2004-01-22 2006-10-11 Pfizer Limited Triazol-derivate zur hemmung der vasopressing-antagonistischen aktivität
BRPI0510340A (pt) * 2004-04-28 2007-10-30 Pfizer derivados de 3-heterociclil-4-feniltriazol como inibidores do receptor via da vasopressina
US20070281044A1 (en) * 2006-06-02 2007-12-06 Mueller Mark J Use of cold-pressed edible seed oils, flours, and/or blends thereof as anti-inflammatory and cox-2 inhibitory agents
UA94979C2 (uk) 2006-12-22 2011-06-25 Рекордати Айеленд Лимитед КОМБІНОВАНА ТЕРАПІЯ ПОРУШЕНЬ НИЖНІХ СЕЧОВИВІДНИХ ШЛЯХІВ ЛІГАНДАМИ α2δ І НПЗП

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434101A (en) * 1981-09-14 1984-02-28 Hoffmann-La Roche Inc. Inhibitors of SRS-synthesis
US5070104A (en) * 1989-02-17 1991-12-03 Wisconsin Alumni Research Foundation Methods of chelating metal and novel compositions therefor
US5017614A (en) * 1989-02-17 1991-05-21 Wisconsin Alumni Research Foundation Methods of preventing oxidation, quenching singlet oxygen and inhibiting mold growth and novel compositions therefor
US5554646A (en) * 1992-04-29 1996-09-10 Wisconsin Alumni Research Foundation Method for reducing body fat in animals
US5430066A (en) * 1992-04-29 1995-07-04 Wisconsin Alumni Research Foundation Methods for preventing weight loss, reduction in weight gain, and anorexia due to immune stimulation
US5428072A (en) * 1992-04-29 1995-06-27 Wisconsin Alumni Research Foundation Method of increasing the efficiency of feed conversion in animals
US5760082C1 (en) * 1994-08-29 2001-03-06 Wisconsin Alumni Res Found Dietetic foods containing conjugated linoleic acids
US5747537A (en) * 1995-09-05 1998-05-05 Washington University Method of inhibiting parasitic activity
US5585400A (en) * 1996-02-27 1996-12-17 Wisconsin Alumni Research Foundation Methods of attenuating the allergic response in animals
US5914346A (en) * 1996-11-05 1999-06-22 Wisconsin Alumni Research Foundation Methods of treating animals to enhance natural killer lymphocyte function
US5851572A (en) * 1997-04-25 1998-12-22 Wisconsin Alumni Research Foundation Method of increasing fat firmness and improving meat quality in animals with conjugated linolenic acid
US6136985A (en) * 1997-12-23 2000-10-24 Dcv, Inc. CLA esters and uses thereof
US6077525A (en) * 1998-04-10 2000-06-20 The George Washington University Use of conjugated linoleic acids

Also Published As

Publication number Publication date
EP1196161B1 (de) 2006-07-26
CA2379649C (en) 2009-03-10
WO2001005395A1 (en) 2001-01-25
EP1196161A1 (de) 2002-04-17
US6077868A (en) 2000-06-20
CA2379649A1 (en) 2001-01-25
DE60029591T2 (de) 2007-08-09
ATE333874T1 (de) 2006-08-15
AU3772000A (en) 2001-02-05
ES2269122T3 (es) 2007-04-01

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