DE60023020T2 - Positive modulatoren von nicotinrezeptor-agonisten - Google Patents

Positive modulatoren von nicotinrezeptor-agonisten Download PDF

Info

Publication number
DE60023020T2
DE60023020T2 DE60023020T DE60023020T DE60023020T2 DE 60023020 T2 DE60023020 T2 DE 60023020T2 DE 60023020 T DE60023020 T DE 60023020T DE 60023020 T DE60023020 T DE 60023020T DE 60023020 T2 DE60023020 T2 DE 60023020T2
Authority
DE
Germany
Prior art keywords
receptor agonists
nicotine receptor
positive modulators
modulators
positive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60023020T
Other languages
German (de)
English (en)
Other versions
DE60023020D1 (de
Inventor
Michael Balestra
David Gurley
James Rosamond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60023020D1 publication Critical patent/DE60023020D1/de
Publication of DE60023020T2 publication Critical patent/DE60023020T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
DE60023020T 1999-11-03 2000-11-01 Positive modulatoren von nicotinrezeptor-agonisten Expired - Fee Related DE60023020T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903996A SE9903996D0 (sv) 1999-11-03 1999-11-03 New compounds
PCT/SE2000/002149 WO2001032620A1 (en) 1999-11-03 2000-11-01 Positive modulators of nicotinic receptor agonists

Publications (2)

Publication Number Publication Date
DE60023020D1 DE60023020D1 (de) 2006-02-16
DE60023020T2 true DE60023020T2 (de) 2006-06-14

Family

ID=20417606

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60023020T Expired - Fee Related DE60023020T2 (de) 1999-11-03 2000-11-01 Positive modulatoren von nicotinrezeptor-agonisten

Country Status (10)

Country Link
US (1) US6756398B1 (enExample)
EP (1) EP1230217B1 (enExample)
JP (1) JP2003513072A (enExample)
AR (1) AR026286A1 (enExample)
AT (1) ATE305925T1 (enExample)
AU (1) AU1745501A (enExample)
CO (1) CO5280192A1 (enExample)
DE (1) DE60023020T2 (enExample)
SE (1) SE9903996D0 (enExample)
WO (1) WO2001032620A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
SE0202598D0 (sv) * 2002-09-02 2002-09-02 Astrazeneca Ab Alpha-7 Nicotinic receptor agonists and statins in combination
US20070134169A1 (en) * 2005-12-11 2007-06-14 Rabinoff Michael D Methods for smoking cessation or alcohol cessation or other addiction cessation
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
TWI519532B (zh) 2010-05-17 2016-02-01 艾維沃製藥公司 (R)-7-氯-N-(啶-3-基)苯並[b]噻吩-2-羧醯胺鹽酸鹽單水合物之結晶形體
RU2017136693A (ru) 2012-05-08 2019-02-08 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2731223A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives bi-tryptaminiques, leur procede de preparation et leur utilisation a titre de medicaments
EP1083918A1 (en) 1998-06-08 2001-03-21 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors

Also Published As

Publication number Publication date
AR026286A1 (es) 2003-02-05
US6756398B1 (en) 2004-06-29
CO5280192A1 (es) 2003-05-30
JP2003513072A (ja) 2003-04-08
WO2001032620A1 (en) 2001-05-10
EP1230217B1 (en) 2005-10-05
SE9903996D0 (sv) 1999-11-03
DE60023020D1 (de) 2006-02-16
AU1745501A (en) 2001-05-14
ATE305925T1 (de) 2005-10-15
EP1230217A1 (en) 2002-08-14

Similar Documents

Publication Publication Date Title
NO20022105D0 (no) Positive modulatorer av nikotinreseptoragonister
NO20022009D0 (no) Positive modulatorer av nikotiniske reseptoragonister
CY2012029I1 (el) Νεα μορφη της s-ομεπραζολης
EE05584B1 (et) Glkokortikoidretseptori modulaatorid
ID24481A (id) Gastrokinetik monosiklik benzamida dari derivat-3-atau-tersubstitusi 4-(aminometil)-piperidin
NO20013183D0 (no) Azabicykloalkaner som CCR5-modulatorer
NO20016116D0 (no) Substituerte heterocykliske fuserte gamma-karboliner
NO996440D0 (no) Omeprazol-natriumsalt
EE200200355A (et) EP4 retseptori selektiivsed agonistid osteoporoosi raviks
FI991485A0 (fi) Uusi farmaseuttinen koostumus
IS5245A (is) Lyfjablanda úr ómeprasól
DE69719191D1 (de) Tetrahydroisoquinoline derivate als modulatoren von dopamine d3 rezeptoren
EE200100395A (et) (S)-omeprasooli kaaliumisool
NO20013456D0 (no) Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer
DE60028368D1 (de) Agonisten des peroxisom aktivator-responsiven rezeptors
DE60023020D1 (de) Positive modulatoren von nicotinrezeptor-agonisten
ATE254929T1 (de) Oralverabreichbare lösung von prucaloprid
ID30056A (id) Agonis-agonis 5-htif
DE69903627D1 (de) Tetrahydroisochinolinderivate als modulatoren von dopamin d3 rezeptoren
ID30381A (id) Penggunaan arilalkanoilpiridazina
FR2798731B1 (fr) Gyroscope vibrant
NO20022142L (no) Anvendelse av dopamin-D3 reseptor agonister for behandling av saltavhengig hypertensjon
DE69825688D1 (de) Einrichtung zur Trocknung von Zucker
SE9903009D0 (sv) Use of new responsive elements
SE9904269D0 (sv) Use of new responsive elements

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee