DE60022021D1 - Zubereitungen enthaltend Apomorphin und Sildenafil und ihre Verwendung zur Behandlung von erektiler Dysfunktion - Google Patents

Zubereitungen enthaltend Apomorphin und Sildenafil und ihre Verwendung zur Behandlung von erektiler Dysfunktion

Info

Publication number
DE60022021D1
DE60022021D1 DE60022021T DE60022021T DE60022021D1 DE 60022021 D1 DE60022021 D1 DE 60022021D1 DE 60022021 T DE60022021 T DE 60022021T DE 60022021 T DE60022021 T DE 60022021T DE 60022021 D1 DE60022021 D1 DE 60022021D1
Authority
DE
Germany
Prior art keywords
sildenafil
treatment
apomorphine
administered
erectile dysfunction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60022021T
Other languages
English (en)
Other versions
DE60022021T2 (de
Inventor
Ragab El-Rashidy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pentech Pharmaceuticals Inc
Original Assignee
Pentech Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentech Pharmaceuticals Inc filed Critical Pentech Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60022021D1 publication Critical patent/DE60022021D1/de
Publication of DE60022021T2 publication Critical patent/DE60022021T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60022021T 1999-03-16 2000-03-14 Zubereitungen enthaltend Apomorphin und Sildenafil und ihre Verwendung zur Behandlung von erektiler Dysfunktion Expired - Fee Related DE60022021T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/270,035 US6087362A (en) 1999-03-16 1999-03-16 Apomorphine and sildenafil composition
US270035 1999-03-16
PCT/US2000/006654 WO2000054774A1 (en) 1999-03-16 2000-03-14 Apomorphine and sildenafil composition

Publications (2)

Publication Number Publication Date
DE60022021D1 true DE60022021D1 (de) 2005-09-22
DE60022021T2 DE60022021T2 (de) 2006-06-08

Family

ID=23029614

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022021T Expired - Fee Related DE60022021T2 (de) 1999-03-16 2000-03-14 Zubereitungen enthaltend Apomorphin und Sildenafil und ihre Verwendung zur Behandlung von erektiler Dysfunktion

Country Status (21)

Country Link
US (1) US6087362A (de)
EP (1) EP1173178B1 (de)
JP (1) JP2002539163A (de)
CN (1) CN1350454A (de)
AT (1) ATE302003T1 (de)
AU (1) AU3744500A (de)
BR (1) BR0009016A (de)
CA (1) CA2367605A1 (de)
CZ (1) CZ20013344A3 (de)
DE (1) DE60022021T2 (de)
DK (1) DK1173178T3 (de)
ES (1) ES2244418T3 (de)
HU (1) HUP0200549A3 (de)
IL (1) IL145487A0 (de)
MX (1) MXPA01009332A (de)
NO (1) NO324511B1 (de)
NZ (1) NZ514464A (de)
PL (1) PL350313A1 (de)
PT (1) PT1173178E (de)
WO (1) WO2000054774A1 (de)
ZA (1) ZA200107920B (de)

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US20040063719A1 (en) * 1998-08-26 2004-04-01 Queen's University At Kingston Combination therapy using antihypertensive agents and endothelin antagonists
US6428769B1 (en) * 1999-05-04 2002-08-06 Aradigm Corporation Acute testosterone administration
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
US20030139384A1 (en) * 2000-08-30 2003-07-24 Dudley Robert E. Method for treating erectile dysfunction and increasing libido in men
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
WO2002017927A1 (en) * 2000-08-30 2002-03-07 Unimed Pharmaceuticals, Inc. Method for treating erectile dysfunction and increasing libido in men
US6821978B2 (en) * 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
BR0207024A (pt) * 2001-02-08 2004-02-25 Pharmacia Corp Global Patent D Medicamento com ação inicial rápida para o tratamento de disfunção sexual
ES2180446B1 (es) * 2001-07-02 2004-01-16 Esteve Labor Dr Empleo de derivados de acidos 2,5-dihidroxibencenosulfonicos en la elaboracion de un medicamento para potenciar el efecto de otros farmacos en el tratamiento de la disfuncion erectil.
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
CN1781920A (zh) * 2001-08-28 2006-06-07 先灵公司 多环鸟嘌呤磷酸二酯酶v抑制剂
US20030114469A1 (en) * 2001-09-27 2003-06-19 Cohen David Saul Combinations
US20030216407A1 (en) * 2002-01-31 2003-11-20 Pfizer Inc. Use of PDE5 inhibitors in the treatment of scarring
CN1720054A (zh) * 2002-03-19 2006-01-11 布雷恩及比扬德生物科技公司 阿朴吗啡和其类似物的糖苷和原酸酯糖苷衍生物及其用途
US8821915B2 (en) 2002-08-09 2014-09-02 Veroscience, Llc Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
US7037257B1 (en) * 2002-08-22 2006-05-02 Koenig J Frank Erectile dysfuction treatments comprising momentary vacuum therapy alone or with medications
TWI330529B (en) * 2003-01-13 2010-09-21 Horphag Res Luxembourg Holding Sa A preparation for improving sperm quality or fertility,a kit comprising the same and uses thereof
GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) * 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
DE10325813B4 (de) 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
KR101292492B1 (ko) * 2004-05-11 2013-08-01 이모셔널 브레인 비.브이. 약제학적 제형물 및 여성 성기능 부전의 치료에서 그것의용도
EP1802312B1 (de) 2004-10-20 2015-09-16 Endorecherche Inc. Vorläufer von sexualsteroiden in kombination mit einem selektiven östrogen-rezeptor-modulator zur prophylaxe und behandlung von vaginaler atrophie bei postmenopausalen frauen
GEP20125432B (en) 2005-10-12 2012-03-26 Unimed Pharmaceuticals Llc Improved testosterone gel and use thereof
NZ579170A (en) * 2007-02-12 2012-05-25 Dmi Biosciences Inc Reducing side effects of tramadol
EP2120570B1 (de) * 2007-02-12 2012-05-16 DMI Biosciences, Inc. Behandlung frühzeitiger comorbid-ejakulation und erektiler dysfunktion
US8741918B2 (en) 2007-06-21 2014-06-03 Veroscience Llc Parenteral formulations of dopamine agonists
US20100035886A1 (en) 2007-06-21 2010-02-11 Veroscience, Llc Parenteral formulations of dopamine agonists
GB0715285D0 (en) * 2007-08-06 2007-09-12 Britannia Pharmaceuticals Ltd Improvements in or relating to powdered medicaments for nasal delivery
US8268806B2 (en) 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
AR069978A1 (es) * 2007-12-26 2010-03-03 Dana Farber Cancer Inst Inc Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd 138
JP5817034B2 (ja) * 2007-12-26 2015-11-18 バイオテスト・アクチエンゲゼルシヤフト Ｃｄ１３８を標的とする免疫複合体及びその使用
EP2238168B8 (de) * 2007-12-26 2014-07-23 Biotest AG Auf cd138 zielende mittel und anwendungen davon
JP2011507933A (ja) * 2007-12-26 2011-03-10 バイオテスト・アクチエンゲゼルシヤフト 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法
US20090246298A1 (en) * 2008-03-31 2009-10-01 Ceola P. Steele Viagra
WO2010070617A1 (en) 2008-12-19 2010-06-24 Shimoda Biotech (Pty) Ltd Inclusion complexes of alpha-cyclodextrin and sildenafil salt
BRPI1013990A2 (pt) * 2009-05-06 2019-04-30 Biotest Ag método para tratar uma doença , e, combinação anticâncer
US9352025B2 (en) 2009-06-05 2016-05-31 Veroscience Llc Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders
KR102017009B1 (ko) 2009-06-12 2019-09-02 선오비온 파마슈티컬스 인코포레이티드 설하 아포모르핀
WO2012000634A1 (de) 2010-06-29 2012-01-05 Georg Bambach Pharmazeutische zusammensetzung zur behandlung von erektiler dysfunktion
TWI462739B (zh) 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
EA031156B1 (ru) 2010-12-16 2018-11-30 Суновион Фармасьютикалз Инк. Сублингвальные пленки
KR20140100571A (ko) 2011-12-08 2014-08-14 바이오테스트 아게 Ｃｄ１３８을 타겟팅하는 면역접합체의 용도
WO2016172095A1 (en) 2015-04-21 2016-10-27 Cynapsus Therapeutics, Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256652A (en) * 1987-11-12 1993-10-26 Pharmedic Co. Topical compositions and methods for treatment of male impotence
DE69534693T2 (de) * 1994-04-22 2006-08-31 Pentech Pharmaceuticals, Inc., Wheeling Sublinguale Zusammensetzung enthaltend Apomorphine zur Diagnose der funktionellen Impotenz
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
EP0996447B1 (de) * 1997-05-19 2006-07-19 Zonagen, Inc. Kombinationstherapie zur modulation der humanen sexualreaktion
US6037346A (en) * 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6200591B1 (en) * 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction

Also Published As

Publication number Publication date
US6087362A (en) 2000-07-11
EP1173178B1 (de) 2005-08-17
NO20014519D0 (no) 2001-09-17
JP2002539163A (ja) 2002-11-19
NZ514464A (en) 2004-01-30
NO20014519L (no) 2001-10-25
ATE302003T1 (de) 2005-09-15
MXPA01009332A (es) 2002-06-21
IL145487A0 (en) 2002-06-30
ZA200107920B (en) 2003-03-26
PT1173178E (pt) 2005-11-30
BR0009016A (pt) 2002-04-16
EP1173178A1 (de) 2002-01-23
AU3744500A (en) 2000-10-04
NO324511B1 (no) 2007-11-05
DK1173178T3 (da) 2005-11-07
DE60022021T2 (de) 2006-06-08
WO2000054774A1 (en) 2000-09-21
CA2367605A1 (en) 2000-09-21
CN1350454A (zh) 2002-05-22
PL350313A1 (en) 2002-12-02
ES2244418T3 (es) 2005-12-16
HUP0200549A3 (en) 2004-07-28
CZ20013344A3 (cs) 2002-08-14
EP1173178A4 (de) 2002-09-04
HUP0200549A2 (hu) 2002-07-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee