DE60020526D1 - Osteogene pastenzusammensetzungen und ihre verwendung - Google Patents

Osteogene pastenzusammensetzungen und ihre verwendung

Info

Publication number
DE60020526D1
DE60020526D1 DE60020526T DE60020526T DE60020526D1 DE 60020526 D1 DE60020526 D1 DE 60020526D1 DE 60020526 T DE60020526 T DE 60020526T DE 60020526 T DE60020526 T DE 60020526T DE 60020526 D1 DE60020526 D1 DE 60020526D1
Authority
DE
Germany
Prior art keywords
compositions
osteogenic
methods
bone
paste compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60020526T
Other languages
English (en)
Other versions
DE60020526T2 (de
Inventor
F Mckay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warsaw Orthopedic Inc
Original Assignee
SDGI Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SDGI Holdings Inc filed Critical SDGI Holdings Inc
Publication of DE60020526D1 publication Critical patent/DE60020526D1/de
Application granted granted Critical
Publication of DE60020526T2 publication Critical patent/DE60020526T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
DE60020526T 1999-02-04 2000-02-04 Osteogene pastenzusammensetzungen und ihre verwendung Expired - Lifetime DE60020526T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11861499P 1999-02-04 1999-02-04
US118614P 1999-02-04
PCT/US2000/003024 WO2000045870A1 (en) 1999-02-04 2000-02-04 Osteogenic paste compositions and uses thereof

Publications (2)

Publication Number Publication Date
DE60020526D1 true DE60020526D1 (de) 2005-07-07
DE60020526T2 DE60020526T2 (de) 2006-05-11

Family

ID=22379688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60020526T Expired - Lifetime DE60020526T2 (de) 1999-02-04 2000-02-04 Osteogene pastenzusammensetzungen und ihre verwendung

Country Status (9)

Country Link
US (2) US7172629B2 (de)
EP (1) EP1150725B1 (de)
JP (1) JP4732587B2 (de)
AT (1) ATE296643T1 (de)
AU (1) AU770196B2 (de)
CA (1) CA2362046A1 (de)
DE (1) DE60020526T2 (de)
ES (1) ES2242600T3 (de)
WO (1) WO2000045870A1 (de)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US7045141B2 (en) * 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US20030147860A1 (en) 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
CA2377435A1 (en) 1999-06-29 2001-01-04 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
IT1311576B1 (it) 1999-10-25 2002-03-13 Ghimas Spa Dispositivo medico invasivo, in particolare per la rigenerazionetissutale guidata.
JP2002058736A (ja) * 2000-08-17 2002-02-26 Seikagaku Kogyo Co Ltd 骨充填用組成物、骨充填用医療用具及び骨充填用キット
ATE494014T1 (de) 2000-10-24 2011-01-15 Cryolife Inc Bioprothetischer füller und methoden, insbesondere für die bildung von bandscheibenbioprothesen in situ
US7226615B2 (en) 2000-11-07 2007-06-05 Cryolife, Inc. Expandable foam-like biomaterials and methods
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
JP5007476B2 (ja) * 2001-03-23 2012-08-22 オリンパス株式会社 人工骨材
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2003043673A1 (en) 2001-11-19 2003-05-30 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties
US8313742B2 (en) * 2002-03-29 2012-11-20 Depuy Acromed, Inc. Cell-containing bone graft material
TW200400062A (en) * 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
CA2483778A1 (en) * 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US8876532B2 (en) 2002-07-31 2014-11-04 Dentsply International Inc. Bone repair putty
US7842300B2 (en) * 2002-07-31 2010-11-30 Dentsply International, Inc. Bone repair putty
PT1539261E (pt) 2002-09-10 2006-08-31 Scil Technology Gmbh Implante metalico revestido sob concentracao reduzida de oxigenio com proteina osteoindutiva
AU2004229502C1 (en) * 2003-04-11 2011-02-24 Etex Corporation Osteoinductive bone material
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
US8153591B2 (en) 2003-08-26 2012-04-10 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
NZ545953A (en) 2003-09-30 2010-09-30 Snow Brand Milk Products Co Ltd Agent for promoting osteogenesis and/or inhibiting bone resorption
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
AU2004296851A1 (en) * 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
EP1701729B1 (de) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Verbesserte knochenmatrixzusammensetzungen und verfahren
JP4944010B2 (ja) 2004-03-10 2012-05-30 サイル テクノロジー ゲーエムベーハー コーティングされたインプラント、その製造および使用
WO2005117919A2 (en) * 2004-04-15 2005-12-15 Etex Corporation Delayed-setting calcium phosphate pastes
US7758896B2 (en) * 2004-04-16 2010-07-20 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
EP1604693A1 (de) * 2004-06-09 2005-12-14 Scil Technology GmbH In-situ hergestelltes Gerüst, dessen Herstellungsverfahren und dessen Verwendung
US20060074422A1 (en) * 2004-09-27 2006-04-06 Story Brooks J Suture anchor and void filler combination
US20060067971A1 (en) * 2004-09-27 2006-03-30 Story Brooks J Bone void filler
US7670384B2 (en) 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
WO2006063381A1 (en) * 2004-12-15 2006-06-22 John Watts Improvements in quilting machines
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
KR100759388B1 (ko) 2005-08-02 2007-09-19 유형근 치조골 골수 유래 성체 줄기세포의 골아세포 분화 방법
US8911759B2 (en) * 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
WO2007056872A1 (en) 2005-11-15 2007-05-24 Dr.H.C. Robert Mathys Stiftung Bone repair material
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US8690957B2 (en) * 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
US7824703B2 (en) 2006-02-01 2010-11-02 Warsaw Orthopedics, Inc. Medical implants with reservoir(s), and materials preparable from same
US7939092B2 (en) * 2006-02-01 2011-05-10 Warsaw Orthopedic, Inc. Cohesive osteogenic putty and materials therefor
US7833270B2 (en) * 2006-05-05 2010-11-16 Warsaw Orthopedic, Inc Implant depots to deliver growth factors to treat osteoporotic bone
EP2046350A4 (de) * 2006-06-22 2011-09-14 Biosurface Eng Tech Inc Zusammensetzungen und verfahren zur freisetzung eines bmp-2-amplifikators/coaktivators für verstärkte osteogenese
US20100047235A1 (en) * 2006-07-07 2010-02-25 Gorman James R Novel regimens for treating diseases and disorders
US20080031914A1 (en) * 2006-08-02 2008-02-07 Drapeau Susan J Flowable biomaterial composition
US7671014B2 (en) * 2006-08-14 2010-03-02 Warsaw Orthopedic, Inc. Flowable carrier matrix and methods for delivering to a patient
US20080112874A1 (en) * 2006-08-31 2008-05-15 Burkes Douglas E Method for producing calcium phosphate powders using an auto-ignition combustion synthesis reaction
US8388626B2 (en) * 2006-11-08 2013-03-05 Warsaw Orthopedic, Inc. Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
EP2148708A4 (de) * 2007-04-18 2012-12-05 Univ Mcgill Zusammensetzung für verstärkte knochenbildung
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9358113B2 (en) 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
US20090110637A1 (en) * 2007-10-26 2009-04-30 Warsaw Orthopedic, Inc. LMP and Regulation of Tissue Growth
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
US20090131950A1 (en) * 2007-11-16 2009-05-21 Liu Y King Vertebroplasty method with enhanced control
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
US20090131867A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US9056150B2 (en) 2007-12-04 2015-06-16 Warsaw Orthopedic, Inc. Compositions for treating bone defects
WO2009073209A1 (en) * 2007-12-06 2009-06-11 Osseon Therapeutics, Inc. Vertebroplasty implant with enhanced interfacial shear strength
WO2009086483A2 (en) * 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein particles, particle devices and methods thereof
US8293813B2 (en) * 2008-03-05 2012-10-23 Biomet Manufacturing Corporation Cohesive and compression resistant demineralized bone carrier matrix
US8840913B2 (en) * 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
US9095569B2 (en) 2008-04-18 2015-08-04 Collplant Ltd. Methods of generating and using procollagen
US8999001B2 (en) * 2008-04-21 2015-04-07 Ao Technology Ag Biocompatible implant
US8039433B2 (en) 2008-08-19 2011-10-18 Warsaw Orthopedic, Inc. Osteogenic compositions containing a coloring agent
US9161903B2 (en) * 2008-10-31 2015-10-20 Warsaw Orthopedic, Inc. Flowable composition that hardens on delivery to a target tissue site beneath the skin
WO2010057177A2 (en) 2008-11-17 2010-05-20 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US9320761B2 (en) 2008-12-18 2016-04-26 Vivex Biomedical, Inc. Bone induction system and methods
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
US20100298832A1 (en) 2009-05-20 2010-11-25 Osseon Therapeutics, Inc. Steerable curvable vertebroplasty drill
US8994666B2 (en) * 2009-12-23 2015-03-31 Colin J. Karpfinger Tactile touch-sensing interface system
US20110223156A1 (en) * 2010-03-11 2011-09-15 Raibekas Andrei A Reversible gel protein formulation
US9125671B2 (en) 2010-04-29 2015-09-08 Dfine, Inc. System for use in treatment of vertebral fractures
WO2011143226A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
WO2012061024A1 (en) * 2010-10-25 2012-05-10 Musculoskeletal Transplant Foundation Demineralized cortical bone implants
US8926710B2 (en) 2010-10-25 2015-01-06 Warsaw Orthopedic, Inc. Osteoinductive bone graft injectable cement
CN103313733A (zh) 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 骨空隙填充剂
WO2013006798A1 (en) 2011-07-06 2013-01-10 University Of Medicine And Dentistry Of New Jersey Vandium compounds as therapeutic adjuncts for cartilage regeneration and repair
US20140322292A1 (en) * 2010-12-10 2014-10-30 Rutgers, The State University Of New Jersey Insulin-mimetics as therapeutic adjuncts for bone regeneration
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
US8998925B2 (en) 2011-06-20 2015-04-07 Rdc Holdings, Llc Fixation system for orthopedic devices
WO2012177759A1 (en) 2011-06-20 2012-12-27 Rdc Holdings, Llc System and method for repairing joints
US8920511B2 (en) 2011-11-17 2014-12-30 Allosource Multi-piece machine graft systems and methods
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
US8697107B2 (en) 2012-04-27 2014-04-15 Warsaw Orthopedic, Inc. Flowable implant with crosslinkable surface membrane
NZ701667A (en) * 2012-05-30 2017-05-26 Klox Tech Inc Compositions and methods for biophotonic bone reconstruction
CA2897855A1 (en) 2013-03-07 2014-09-12 Allosource Consistent calcium content bone allograft systems and methods
KR102312720B1 (ko) 2013-03-15 2021-10-13 알로소스 연조직 회복 및 재생을 위한 세포 재배치된 콜라겐 매트릭스
KR20160042064A (ko) * 2013-08-09 2016-04-18 군제 가부시키가이샤 골 재생 재료 키트, 페이스트상 골 재생 재료, 골 재생 재료 및 골 접합재
US9730796B2 (en) 2014-05-16 2017-08-15 Allosource Composite bone constructs and methods
US10130678B2 (en) 2014-12-29 2018-11-20 Bioventus, LLC. Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2016187413A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
CN109862834B (zh) 2016-10-27 2022-05-24 Dfine有限公司 具有接合剂递送通道的可弯曲的骨凿
AU2017363356B2 (en) 2016-11-28 2023-02-09 Dfine, Inc. Tumor ablation devices and related methods
EP3551100B1 (de) 2016-12-09 2021-11-10 Dfine, Inc. Medizinische vorrichtungen zur behandlung von hartgeweben
WO2018129180A1 (en) 2017-01-06 2018-07-12 Dfine, Inc. Osteotome with a distal portion for simultaneous advancement and articulation
EP3645066A1 (de) 2017-06-30 2020-05-06 Allosource Zelluläre knochentransplantate, verfahren zur herstellung und verwendung
BR112021006752A2 (pt) 2018-10-12 2021-07-13 Theradaptive, Inc. polipeptídeos incluindo uma sequência de ligação de betafosfato tricálcico e usos dos mesmos
US11937864B2 (en) 2018-11-08 2024-03-26 Dfine, Inc. Ablation systems with parameter-based modulation and related devices and methods
CN113908341A (zh) * 2021-10-26 2022-01-11 深圳市迈捷生命科学有限公司 一种可注射型骨诱导修复材料及其制备方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789663A (en) 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US4888366A (en) 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
CA1260391A (en) 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US5246457A (en) 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US4774227A (en) 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
US5904718A (en) * 1986-03-27 1999-05-18 Biocoll Laboratories, Inc. Delayed drug delivery system
US4865602A (en) 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
WO1989004646A1 (en) * 1987-11-13 1989-06-01 Jefferies Steven R Bone repair material and delayed drug delivery
US5024841A (en) 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
DE69331096T2 (de) * 1992-02-28 2002-08-14 Cohesion Tech Inc Injektierbare, keramische verbindungen sowie verfahren zur deren herstellung und anwendung
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
IT1260148B (it) * 1992-04-17 1996-03-28 Fidia Spa Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
US5532217A (en) 1992-04-24 1996-07-02 Silver; Frederick H. Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
US5343877A (en) * 1992-09-09 1994-09-06 University Of Iowa Research Foundation Orthopedic implant and method
US5525148A (en) * 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5507813A (en) * 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
AU3795395A (en) * 1994-11-30 1996-06-06 Ethicon Inc. Hard tissue bone cements and substitutes
US5636594A (en) 1995-06-05 1997-06-10 Servando R. Pina Portable cat litter case and travel kit
WO1996039203A1 (en) * 1995-06-06 1996-12-12 Gensci Regeneration Laboratories, Inc. Modified osteogenic materials
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5702449A (en) * 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
ES2329953T3 (es) * 1996-04-19 2009-12-02 Osiris Therapeutics, Inc. Regeneracion e incremento de hueso utilizando celulas madre mesenquimales.
AU734950B2 (en) * 1996-10-24 2001-06-28 Warsaw Orthopedic, Inc. Ceramic fusion implants and compositions containing osteoinductive factors
US6083522A (en) 1997-01-09 2000-07-04 Neucoll, Inc. Devices for tissue repair and methods for preparation and use thereof
WO1998034655A1 (en) * 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6679918B1 (en) 1997-02-13 2004-01-20 Centerpulse Biologics Inc. Implantable putty material
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
US5977204A (en) 1997-04-11 1999-11-02 Osteobiologics, Inc. Biodegradable implant material comprising bioactive ceramic
US20020076429A1 (en) * 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US6328765B1 (en) 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
ATE253385T1 (de) 1999-02-04 2003-11-15 Sdgi Holdings Inc Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being

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CA2362046A1 (en) 2000-08-10
AU2756400A (en) 2000-08-25
JP2002536076A (ja) 2002-10-29
US20040002558A1 (en) 2004-01-01
EP1150725A1 (de) 2001-11-07
ES2242600T3 (es) 2005-11-16
AU770196B2 (en) 2004-02-12
WO2000045870A1 (en) 2000-08-10
DE60020526T2 (de) 2006-05-11
US8101676B2 (en) 2012-01-24
JP4732587B2 (ja) 2011-07-27
ATE296643T1 (de) 2005-06-15
EP1150725B1 (de) 2005-06-01
US20070128249A1 (en) 2007-06-07
US7172629B2 (en) 2007-02-06

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