DE60017551D1 - Stickstoff-senf-verbindungen und prodrugs dafür - Google Patents
Stickstoff-senf-verbindungen und prodrugs dafürInfo
- Publication number
- DE60017551D1 DE60017551D1 DE60017551T DE60017551T DE60017551D1 DE 60017551 D1 DE60017551 D1 DE 60017551D1 DE 60017551 T DE60017551 T DE 60017551T DE 60017551 T DE60017551 T DE 60017551T DE 60017551 D1 DE60017551 D1 DE 60017551D1
- Authority
- DE
- Germany
- Prior art keywords
- nitrogen
- compounds
- senf
- connections
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9907414.8A GB9907414D0 (en) | 1999-03-31 | 1999-03-31 | Improvements relating to prodrugs |
GB9907414 | 1999-03-31 | ||
PCT/GB2000/001194 WO2000058271A1 (en) | 1999-03-31 | 2000-03-29 | Nitrogen mustard compounds and prodrugs therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60017551D1 true DE60017551D1 (de) | 2005-02-24 |
DE60017551T2 DE60017551T2 (de) | 2006-01-12 |
Family
ID=10850714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60017551T Expired - Fee Related DE60017551T2 (de) | 1999-03-31 | 2000-03-29 | Stickstoff-senf-verbindungen und prodrugs dafür |
Country Status (10)
Country | Link |
---|---|
US (1) | US6852755B1 (de) |
EP (1) | EP1165493B1 (de) |
JP (1) | JP2002540186A (de) |
AT (1) | ATE287391T1 (de) |
AU (1) | AU3974600A (de) |
CA (1) | CA2364622A1 (de) |
DE (1) | DE60017551T2 (de) |
GB (1) | GB9907414D0 (de) |
NZ (1) | NZ513759A (de) |
WO (1) | WO2000058271A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0220319D0 (en) | 2002-09-02 | 2002-10-09 | Cancer Res Campaign Tech | Enzyme activated self-immolative nitrogen mustard drugs |
WO2008041059A1 (en) | 2006-10-03 | 2008-04-10 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
GB8820850D0 (en) | 1988-09-05 | 1988-10-05 | Cancer Res Campaign Tech | Improvements relating to pro-drugs |
CA2066053C (en) | 1989-08-18 | 2001-12-11 | Harry E. Gruber | Recombinant retroviruses delivering vector constructs to target cells |
GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
GB8920011D0 (en) | 1989-09-05 | 1989-10-18 | Mann J | New route of synthesis for tertiary butyl esters |
EP0572401B2 (de) | 1991-02-19 | 2007-11-07 | The Regents of the University of California | Viruspartikel mit veraendertem wirtspektrum |
CA2117303C (en) | 1991-11-29 | 2000-10-17 | Sunil Chada | Anti-cancer immunotherapeutic vector constructs |
GB9314960D0 (en) | 1992-07-23 | 1993-09-01 | Zeneca Ltd | Chemical compounds |
GB9308957D0 (en) * | 1993-04-30 | 1993-06-16 | Cancer Res Campaign Tech | Novel produgs |
DE69435224D1 (de) | 1993-09-15 | 2009-09-10 | Novartis Vaccines & Diagnostic | Rekombinante Alphavirus-Vektoren |
KR960703172A (ko) | 1993-11-18 | 1996-06-19 | 스티븐 제이. 멘토 | 조건적으로 치사적인 유전자를 활용하기 위한 조성물 및 방법(Compositions and methods for utilizing conditionally lethal genes) |
GB9415167D0 (en) | 1994-07-27 | 1994-09-14 | Springer Caroline J | Improvements relating to cancer therapy |
GB9501052D0 (en) | 1995-01-19 | 1995-03-08 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
GB9514993D0 (en) * | 1995-07-21 | 1995-09-20 | Pharmacia Spa | Site specific phenyl nitrogen mustards |
GB9601640D0 (en) | 1996-01-26 | 1996-03-27 | Cancer Res Campaign Tech | Ligand directed enzyme prodrug therapy |
-
1999
- 1999-03-31 GB GBGB9907414.8A patent/GB9907414D0/en not_active Ceased
-
2000
- 2000-03-29 EP EP00918981A patent/EP1165493B1/de not_active Expired - Lifetime
- 2000-03-29 US US09/937,714 patent/US6852755B1/en not_active Expired - Lifetime
- 2000-03-29 DE DE60017551T patent/DE60017551T2/de not_active Expired - Fee Related
- 2000-03-29 JP JP2000607975A patent/JP2002540186A/ja active Pending
- 2000-03-29 WO PCT/GB2000/001194 patent/WO2000058271A1/en active IP Right Grant
- 2000-03-29 NZ NZ513759A patent/NZ513759A/xx not_active Application Discontinuation
- 2000-03-29 AU AU39746/00A patent/AU3974600A/en not_active Abandoned
- 2000-03-29 CA CA002364622A patent/CA2364622A1/en not_active Abandoned
- 2000-03-29 AT AT00918981T patent/ATE287391T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2002540186A (ja) | 2002-11-26 |
AU3974600A (en) | 2000-10-16 |
WO2000058271A1 (en) | 2000-10-05 |
EP1165493B1 (de) | 2005-01-19 |
US6852755B1 (en) | 2005-02-08 |
GB9907414D0 (en) | 1999-05-26 |
DE60017551T2 (de) | 2006-01-12 |
CA2364622A1 (en) | 2000-10-05 |
NZ513759A (en) | 2001-09-28 |
ATE287391T1 (de) | 2005-02-15 |
EP1165493A1 (de) | 2002-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |