DE60016226D1 - Cyklische amide und imide und deren verwendung als alpha-1d adrenergische rezeptor-antagonisten - Google Patents
Cyklische amide und imide und deren verwendung als alpha-1d adrenergische rezeptor-antagonistenInfo
- Publication number
- DE60016226D1 DE60016226D1 DE60016226T DE60016226T DE60016226D1 DE 60016226 D1 DE60016226 D1 DE 60016226D1 DE 60016226 T DE60016226 T DE 60016226T DE 60016226 T DE60016226 T DE 60016226T DE 60016226 D1 DE60016226 D1 DE 60016226D1
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- alkyl
- halogen
- compounds
- adrenergic receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001578A ITMI991578A1 (it) | 1999-07-15 | 1999-07-15 | Amidi e imidi cicliche dotate di attivita' antagonista selettiva per il recettore adrenergico |
PCT/EP2000/006738 WO2001005765A1 (en) | 1999-07-15 | 2000-07-14 | Cyclic amides and imides having selective antagonist activity at alpha-1d adrenergic receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60016226D1 true DE60016226D1 (de) | 2004-12-30 |
Family
ID=11383356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60016226T Expired - Lifetime DE60016226D1 (de) | 1999-07-15 | 2000-07-14 | Cyklische amide und imide und deren verwendung als alpha-1d adrenergische rezeptor-antagonisten |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1200406B1 (de) |
JP (1) | JP2003505375A (de) |
AT (1) | ATE283261T1 (de) |
AU (1) | AU5985000A (de) |
DE (1) | DE60016226D1 (de) |
IT (1) | ITMI991578A1 (de) |
WO (1) | WO2001005765A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2338037A1 (en) | 1998-07-17 | 2000-01-27 | Synaptic Pharmaceutical Corporation | Compounds specific for the human .alpha.1d adrenergic receptor and uses thereof |
WO2003084928A1 (en) * | 2002-04-08 | 2003-10-16 | Ranbaxy Laboratories Limited | Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers |
WO2005037281A1 (en) * | 2003-10-15 | 2005-04-28 | Ranbaxy Laboratories Limited | 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist |
WO2008050732A1 (fr) * | 2006-10-23 | 2008-05-02 | Takeda Pharmaceutical Company Limited | Dérivé de l'iminopyridine et son utilisation |
US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
WO2010137620A1 (ja) * | 2009-05-27 | 2010-12-02 | 武田薬品工業株式会社 | フェノキシエチルアミン誘導体 |
CN110229140B (zh) * | 2013-04-12 | 2022-06-10 | 制药有限责任公司 | 戊二酰亚胺衍生物、其用途、基于所述衍生物的药物组合物及戊二酰亚胺衍生物的制备方法 |
WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
AR116020A1 (es) | 2018-09-03 | 2021-03-25 | Bayer Ag | COMPUESTOS DE 3,9-DIAZAESPIRO[5.5]UNDECANO COMO INHIBIDORES DE GGTasa I Y SU USO PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0911330B1 (de) * | 1997-10-22 | 2007-12-12 | Council of Scientific & Industrial Research | 1-(4-Arylpiperazin-1-yl)-3-(2-oxopyrrolidin/piperidin-1-yl)propane als therapeutische Mittel bei Bluthochdruck, Ischämie,kardiovaskulären und anderen,mit adrenergenen Rezeptoren im Zusammenhang stehenden Störungen |
CA2338037A1 (en) * | 1998-07-17 | 2000-01-27 | Synaptic Pharmaceutical Corporation | Compounds specific for the human .alpha.1d adrenergic receptor and uses thereof |
-
1999
- 1999-07-15 IT IT1999MI001578A patent/ITMI991578A1/it unknown
-
2000
- 2000-07-14 DE DE60016226T patent/DE60016226D1/de not_active Expired - Lifetime
- 2000-07-14 EP EP00945917A patent/EP1200406B1/de not_active Expired - Lifetime
- 2000-07-14 AU AU59850/00A patent/AU5985000A/en not_active Abandoned
- 2000-07-14 JP JP2001511426A patent/JP2003505375A/ja active Pending
- 2000-07-14 AT AT00945917T patent/ATE283261T1/de not_active IP Right Cessation
- 2000-07-14 WO PCT/EP2000/006738 patent/WO2001005765A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE283261T1 (de) | 2004-12-15 |
WO2001005765A1 (en) | 2001-01-25 |
ITMI991578A1 (it) | 2001-01-15 |
JP2003505375A (ja) | 2003-02-12 |
EP1200406A1 (de) | 2002-05-02 |
EP1200406B1 (de) | 2004-11-24 |
AU5985000A (en) | 2001-02-05 |
ITMI991578A0 (it) | 1999-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |