DE60013338D1 - Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin Komplex - Google Patents

Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin Komplex

Info

Publication number
DE60013338D1
DE60013338D1 DE60013338T DE60013338T DE60013338D1 DE 60013338 D1 DE60013338 D1 DE 60013338D1 DE 60013338 T DE60013338 T DE 60013338T DE 60013338 T DE60013338 T DE 60013338T DE 60013338 D1 DE60013338 D1 DE 60013338D1
Authority
DE
Germany
Prior art keywords
polyoxyalkylene
hemoglobin complex
nitric monoxide
monoxide metabolite
metabolite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60013338T
Other languages
English (en)
Other versions
DE60013338T2 (de
Inventor
Akira Kitabatake
Ichiro Sakuma
Kunihiko Nakai
Tohru Yasukohchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
NOF Corp
Original Assignee
Hokkaido University NUC
NOF Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, NOF Corp filed Critical Hokkaido University NUC
Application granted granted Critical
Publication of DE60013338D1 publication Critical patent/DE60013338D1/de
Publication of DE60013338T2 publication Critical patent/DE60013338T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE60013338T 1999-02-08 2000-02-08 Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin Komplex Expired - Fee Related DE60013338T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6723999 1999-02-08
JP11067239A JP2000230000A (ja) 1999-02-08 1999-02-08 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体

Publications (2)

Publication Number Publication Date
DE60013338D1 true DE60013338D1 (de) 2004-10-07
DE60013338T2 DE60013338T2 (de) 2005-09-08

Family

ID=13339178

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60013338T Expired - Fee Related DE60013338T2 (de) 1999-02-08 2000-02-08 Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin Komplex

Country Status (4)

Country Link
US (1) US6667292B1 (de)
EP (1) EP1029551B1 (de)
JP (1) JP2000230000A (de)
DE (1) DE60013338T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4841066B2 (ja) * 2000-09-01 2011-12-21 ライスユニバーシティ 酸化窒素生成ヒドロゲル物質
JP4412461B2 (ja) * 2002-11-20 2010-02-10 日油株式会社 修飾された生体関連物質、その製造方法および中間体
US8003117B2 (en) * 2002-11-20 2011-08-23 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance
US8828373B2 (en) * 2002-11-20 2014-09-09 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance
HUE051389T2 (hu) * 2013-10-15 2021-03-01 Seagen Inc Pegilezett gyógyszer-linkerek ligandum-gyógyszer konjugátum javított farmakokinetikájához
GB201506236D0 (en) * 2015-04-13 2015-05-27 Jellagen Pty Ltd Modified collagen, methods of manufacture thereof
SG11201807827VA (en) 2016-03-25 2018-10-30 Seattle Genetics Inc Process for the preparation of pegylated drug-linkers and intermediates thereof
JP2020512312A (ja) 2017-03-24 2020-04-23 シアトル ジェネティックス， インコーポレイテッド グルクロニド薬物−リンカーの調製のためのプロセスおよびその中間体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPS6153223A (ja) 1984-08-22 1986-03-17 Ajinomoto Co Inc ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法
EP0206448B1 (de) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
WO1996030006A1 (en) * 1995-03-24 1996-10-03 Brigham And Women's Hospital Nitrosylated blood substitutes
WO1997018000A1 (en) 1995-11-13 1997-05-22 Brigham And Women's Hospital S-nitroso-hemoglobin and therapeutic uses thereof
AU6150298A (en) * 1997-02-06 1998-08-26 Duke University Medical Center No-modified hemoglobins and uses therefor

Also Published As

Publication number Publication date
DE60013338T2 (de) 2005-09-08
US6667292B1 (en) 2003-12-23
JP2000230000A (ja) 2000-08-22
EP1029551A3 (de) 2001-03-07
EP1029551B1 (de) 2004-09-01
EP1029551A2 (de) 2000-08-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee