DE60004652D1 - Verfahren zur herstellung von gabapentin - Google Patents

Verfahren zur herstellung von gabapentin

Info

Publication number
DE60004652D1
DE60004652D1 DE60004652T DE60004652T DE60004652D1 DE 60004652 D1 DE60004652 D1 DE 60004652D1 DE 60004652 T DE60004652 T DE 60004652T DE 60004652 T DE60004652 T DE 60004652T DE 60004652 D1 DE60004652 D1 DE 60004652D1
Authority
DE
Germany
Prior art keywords
gabapentin
retentate
solution
unsalified
addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004652T
Other languages
English (en)
Other versions
DE60004652T2 (de
Inventor
Franco Tenconi
Cristiana Giordani
Nicola Caraccia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOINDUSTRIA LAB ITALIANO MEDI
Original Assignee
BIOINDUSTRIA LAB ITALIANO MEDI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOINDUSTRIA LAB ITALIANO MEDI filed Critical BIOINDUSTRIA LAB ITALIANO MEDI
Publication of DE60004652D1 publication Critical patent/DE60004652D1/de
Application granted granted Critical
Publication of DE60004652T2 publication Critical patent/DE60004652T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Pyridine Compounds (AREA)
DE60004652T 1999-03-26 2000-03-16 Verfahren zur herstellung von gabapentin Expired - Lifetime DE60004652T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI000625A IT1311984B1 (it) 1999-03-26 1999-03-26 Procedimento per la preparzione di gabapentin.
ITMI990625 1999-03-26
PCT/EP2000/002345 WO2000058268A1 (en) 1999-03-26 2000-03-16 A process for the preparation of gabapentin

Publications (2)

Publication Number Publication Date
DE60004652D1 true DE60004652D1 (de) 2003-09-25
DE60004652T2 DE60004652T2 (de) 2004-06-24

Family

ID=11382457

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004652T Expired - Lifetime DE60004652T2 (de) 1999-03-26 2000-03-16 Verfahren zur herstellung von gabapentin

Country Status (11)

Country Link
US (1) US6576790B1 (de)
EP (1) EP1165489B1 (de)
AT (1) ATE247628T1 (de)
AU (1) AU3290400A (de)
CA (1) CA2368476C (de)
DE (1) DE60004652T2 (de)
DK (1) DK1165489T3 (de)
ES (1) ES2204533T3 (de)
IT (1) IT1311984B1 (de)
PT (1) PT1165489E (de)
WO (1) WO2000058268A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228771B1 (en) * 1998-05-15 2013-05-28 Warner Lambert Co Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same
ITMI20012750A1 (it) 2001-12-21 2003-06-21 Procos Spa Processo per la produzione dell'acido 1-(amminometil)-cicloesil-acetico in forma pura
US20040034248A1 (en) * 2002-04-16 2004-02-19 Taro Pharmaceutical Industries, Ltd. Process for preparing gabapentin
US7196216B2 (en) * 2002-11-18 2007-03-27 Nicholas Piramal India Limited Process for preparation of Gabapentin
ES2339756T3 (es) 2002-11-20 2010-05-25 Hikal Ltd. Procedimiento mejorado para la preparacion de acidos aminometilcicloalcanaceticos.
US20070043236A1 (en) * 2003-05-19 2007-02-22 Chandiran Thakashina M Process for preparation of gabapentin
ITMI20031247A1 (it) * 2003-06-20 2004-12-21 Zambon Spa Processo per la purificazione di gabapentina
US20050187295A1 (en) * 2004-02-19 2005-08-25 Surendra Kalyan Processes for the preparation of gabapentin
ITMI20040579A1 (it) 2004-03-25 2004-06-25 Zambon Spa Processo di preparazione di gabapentina
ES2246159B1 (es) * 2004-07-22 2007-03-16 Menadiona, S.L. Procedimiento para la obtencion de aminoacidos ciclicos.
CN116693410A (zh) * 2023-06-08 2023-09-05 浙江竹子制药有限公司 一种粒径可控的加巴喷丁制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4960931A (en) * 1988-05-02 1990-10-02 Warner-Lambert Company Gabapentin mohohydrate and a process for producing the same
US4894476A (en) * 1988-05-02 1990-01-16 Warner-Lambert Company Gabapentin monohydrate and a process for producing the same
DE3928184A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
US5491259A (en) * 1994-09-13 1996-02-13 The Dow Chemical Company Process to produce aminocarboxylic acids containing low residual salt
IL119890A (en) * 1996-12-24 2002-03-10 Teva Pharma Gabapentin form iii and preparation of gabapentin form ii

Also Published As

Publication number Publication date
CA2368476A1 (en) 2000-10-05
US6576790B1 (en) 2003-06-10
EP1165489A1 (de) 2002-01-02
WO2000058268A1 (en) 2000-10-05
ITMI990625A1 (it) 2000-09-26
ATE247628T1 (de) 2003-09-15
ES2204533T3 (es) 2004-05-01
AU3290400A (en) 2000-10-16
CA2368476C (en) 2009-12-08
EP1165489B1 (de) 2003-08-20
PT1165489E (pt) 2003-12-31
DE60004652T2 (de) 2004-06-24
IT1311984B1 (it) 2002-03-22
DK1165489T3 (da) 2003-12-15

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