DE557307C - Process for the production of irritant-free, long-lasting morphine solutions - Google Patents

Process for the production of irritant-free, long-lasting morphine solutions

Info

Publication number
DE557307C
DE557307C DEW75814D DEW0075814D DE557307C DE 557307 C DE557307 C DE 557307C DE W75814 D DEW75814 D DE W75814D DE W0075814 D DEW0075814 D DE W0075814D DE 557307 C DE557307 C DE 557307C
Authority
DE
Germany
Prior art keywords
morphine
free
lasting
irritant
long
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEW75814D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WOELM AKT GES M
Original Assignee
WOELM AKT GES M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WOELM AKT GES M filed Critical WOELM AKT GES M
Priority to DEW75814D priority Critical patent/DE557307C/en
Application granted granted Critical
Publication of DE557307C publication Critical patent/DE557307C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung. von reizlosen, längere Zeit haltbaren Morphiumlösungen Es ist eine bekannte Tatsache, daß Morphiumlösungen nicht reizlos injiziert werden können, da sie sauer reagieren. Um diesem Übelstand zu begegnen, hat man bisher Na-. triumbicarbonat zum Abstumpfen der sauren Lösungen benutzt. Die Verwendung des Natriumbicarbonats hat aber den Nachteil, daß sich die so behandelten Lösungen alsbald trüben und dann nicht mehr zu Injektionen verwendet werden können.Method of manufacture. of irritant-free, long-lasting morphine solutions It is a known fact that morphine solutions are not injected without irritation because they react sourly. So far, one has to counter this evil N / A-. trium bicarbonate is used to blunt acidic solutions. The usage of the sodium bicarbonate has the disadvantage that the solutions treated in this way soon become cloudy and can then no longer be used for injections.

Es wurde nun gefunden, daß man reizlose,, dabei längere Zeit haltbare Morphiumlösungen erhalten kann, wenn man denselben so viel Dinatriumphosphat zusetzt, bis sie die Wasserstoffionenkonzentration des Blutes (7,z bis 7,5) erreicht haben, ohne daß Abscheidurigen der Base erfolgen.It has now been found that irritation-free, long-lasting Morphine solutions can be obtained by adding so much disodium phosphate to them, until they have reached the hydrogen ion concentration in the blood (7, z to 7.5), without the base being deposited.

Um eine Zersetzung der Lösungen durch längeres Lagern auszuschalten, werden die einzelnen Lösungskomponenten in den Teilbehältern eines geschlossenen, an sich bekannten Doppelampullensystems getrennt aufbewahrt und erst kurz vor dem Gebrauch zusammengebracht.To avoid decomposition of the solutions due to prolonged storage, the individual solution components are stored in the partial containers of a closed, per se known double ampoule system stored separately and only shortly before Use matched.

Die Morphiumkomponente kann dabei als Lösung oder auch in trockener Form in dem einen Teilbehälter der Doppelampulle untergebracht sein und die wässerige Dinatriumphosphatlösung in dem andern Teilbehälter derselben. Die Verwendung der Morphiumsalzlösung bietet derjenigen von Morphiumtrockensubstanz gegenüber den Vorteil einfacherer und zuverlässigerer Dosierung; dagegen hat die letztere vor ersterer den. Vorzug, sich nicht so leicht zu verfärben.The morphine component can be used as a solution or in a dry form Form to be housed in the one part container of the double ampoule and the aqueous one Disodium phosphate solution in the other partial container of the same. Using the Morphine salt solution has the advantage over that of dry morphine substance easier and more reliable dosing; on the other hand, the latter has before the former the. Advantage of not staining easily.

Als Doppelampullen finden vorteilhaft die an sich bekannten, mit zwei voneinander getrennten Teilbehältern Verwendung, deren Trennwand beim Zusammenbringen der beiden Komponenten geöffnet wird. Die Füllung der beiden Teilbehälter erfolgt zweckmäßig von ihren äußeren freien, zunächst offenen Enden aus, die dann nach erfolgter Füllung zugeschmolzen werden.The double ampoules which are known per se, with two, are advantageous separate partial containers use, their partition when brought together of the two components is opened. The two partial containers are filled expediently from their outer free, initially open ends, which then after Filling are melted shut.

Claims (3)

PATENTANSPRÜCHE: r. Verfahren zur Herstellung von reizlosen, längere Zeit haltbaren Morphiumlösungen, dadurch gekennzeichnet, daß man einer Morphiumsalzlösung so viel Dinatriumphosphat zufügt, bis die Wasserstoff ionenkonzentration der Lösung derjenigen des Blutes entspricht (7,2 bis 7t5). PATENT CLAIMS: r. Process for the preparation of irritant-free, longer-lasting morphine solutions, characterized in that enough disodium phosphate is added to a morphine salt solution until the hydrogen ion concentration of the solution corresponds to that of the blood (7.2 to 7t5). 2. Verfahren zur Herstellung von reizlosen, längere Zeit haltbaren Morphiumlösungen nach Anspruch r, dadurch gekennzeichnet, daß man die Lösungskomponenten bis zur Injektion in an sich bekannter Weise in den Teilbehältern eines geschlossenen Doppelampullensystems aufbewahrt. 2. Process for the production of Irritant-free, long-lasting morphine solutions according to claim r, characterized in that that the solution components are known per se up to the injection way stored in the partial containers of a closed double ampoule system. 3. Verfahren zur Herstellung von reizlosen, längere Zeit haltbaren Morphiüm-Lösungen nach den Ansprüchen r und a, dadurch gekennzeichnet, daß die Morphiumsubstanz in trockener Form in einem der Teilbehälter einer Doppelampulle untergebracht ist.3. Procedure for the production of irritant-free, long-lasting morphine solutions according to the Claims r and a, characterized in that the morphine substance in dry Form is housed in one of the partial containers of a double ampoule.
DEW75814D 1927-05-03 1927-05-03 Process for the production of irritant-free, long-lasting morphine solutions Expired DE557307C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEW75814D DE557307C (en) 1927-05-03 1927-05-03 Process for the production of irritant-free, long-lasting morphine solutions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEW75814D DE557307C (en) 1927-05-03 1927-05-03 Process for the production of irritant-free, long-lasting morphine solutions

Publications (1)

Publication Number Publication Date
DE557307C true DE557307C (en) 1933-08-18

Family

ID=7609982

Family Applications (1)

Application Number Title Priority Date Filing Date
DEW75814D Expired DE557307C (en) 1927-05-03 1927-05-03 Process for the production of irritant-free, long-lasting morphine solutions

Country Status (1)

Country Link
DE (1) DE557307C (en)

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