DE575970C - Method for the preparation of masses for the preparation of thyroxine solutions which remain clear for a long time - Google Patents
Method for the preparation of masses for the preparation of thyroxine solutions which remain clear for a long timeInfo
- Publication number
- DE575970C DE575970C DE1930575970D DE575970DD DE575970C DE 575970 C DE575970 C DE 575970C DE 1930575970 D DE1930575970 D DE 1930575970D DE 575970D D DE575970D D DE 575970DD DE 575970 C DE575970 C DE 575970C
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- thyroxine
- masses
- long time
- remain clear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 title claims description 16
- 229940034208 thyroxine Drugs 0.000 title claims description 15
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 title claims description 15
- 238000002360 preparation method Methods 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 2
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 2
- 239000004571 lime Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000007774 longterm Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 4
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- -1 B. urea Chemical compound 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000003165 hydrotropic effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229940077386 sodium benzenesulfonate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical compound [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung von Massen für die Bereitung lange Zeit klarbleibender Thyroxinlösungen In der letzten Zeit hat sich das Thyroxin als Mittel zur Beeinflussung des Stoffwechsels immer mehr in den Arzneischatz eingebürgert. Die übliche Darreichungsform ist die Injektion. Doch fehlte es auch nicht an Versuchen, das Thyroxin peroral zu geben.Method of representing masses for the preparation long time Thyroxine solutions which remain clear In the last time the thyroxine has been used as a means to influence the metabolism more and more naturalized in the medicinal treasure. The usual form of administration is injection. But there was also no lack of attempts To give thyroxine inside.
Eine leicht lösliche Thyroxintablette fehlte bisher hauptsächlich wohl deshalb, weil die im gewöhnlichen Trinkwasser stets enthaltenen Kalksalze sich mit dem Thyroxinsalz umsetzen und zu Ausfällungen Veranlassung geben, die die gewünschte Wirksamkeit stark herabsetzen und den Lösungen ein unschönes Aussehen geben.An easily soluble thyroxine tablet was mainly missing up to now probably because the calcium salts always contained in ordinary drinking water are react with the thyroxine salt and cause precipitations that cause the desired Greatly reduce the effectiveness and give the solutions an unattractive appearance.
Es wurde gefunden, daß man Massen, die zur Bereitung auch bei Gegenwart von Kalksalzen lange Zeit klarbleibender Thyroxinlösungen geeignet sind, erhalten kann, wenn man dem Thyroxin oder seinen Salzen hydrotrope Substanzen, z. B. die Sulfosäuren aromatischer Kohlenwasserstoffe und ihre Derivate, oder die Amide der Kohlensäure, wie z. B. Harnstoff, oder die Äther der Amide der Kohlensäure, wie Urethan, zusetzt. Diese Massen, die zweckmäßig in Tabletten gepreßt werden, geben auch mit gewöhnlichem Trinkwasser Lösungen des Thyroxins, die lange klar bleiben und in denen das Thyroxin in leicht resorbierbarer Form enthalten ist, so daß keine Überdosierung an Hormon zur Erreichung der vollen Wirkung notwendig ist.It has been found that you can use masses for preparation even at the present of lime salts of thyroxine solutions which remain clear for a long time are obtained can, if the thyroxine or its salts hydrotropic substances such. B. the Sulphonic acids of aromatic hydrocarbons and their derivatives, or the amides of Carbonic acid, such as B. urea, or the ethers of the amides of carbonic acid, such as Urethane, adds. These masses, which are expediently compressed into tablets, give solutions of thyroxine, which remain clear for a long time, also with ordinary drinking water and in which the thyroxine is contained in an easily absorbable form, so that none Overdosage of hormone is necessary to achieve the full effect.
Durch Zumischung von kohlensäureentwikkelnden Substanzen zu diesen Massen kann die Auflösung der Tabletten in Wasser sehr beschleunigt werden.By adding carbonic acid developing substances to them By mass, the dissolution of the tablets in water can be greatly accelerated.
Beispiel i Th;roxin als Mono- oder Dinatriumsalz ioo mg, benzolsulfosaures Natrium 309, daraus ioo Tabletten.Example i Th; roxine as the mono- or disodium salt 100 mg, sodium benzenesulfonate 309, from it 100 tablets.
Beispiel 2 Thyroxin, wie oben, ioo mg, Urethan 3o g, daraus ioo Tabletten.Example 2 Thyroxine, as above, 100 mg, urethane 30 g, from it 100 tablets.
Beispiel 3 Thyroxin ioo mg, wie oben, Urethan 18 g, calc. Soda i g, Weinsäure i g, daraus ioo Tabletten.Example 3 thyroxine ioo mg, as above, urethane 1 8 g, calc. Soda ig, tartaric acid ig, from them 100 tablets.
Beispiel q.Example q.
ioo rng Thyroxin werden als Mono- oder Dinatriumsalz mit :2o g salicylsaurem Natrium vermischt. Aus dem Gemisch werden ioo Tabletten gepreßt. Beispiels Man prellt 9 g Thyroxin, . 9 g NatriumhydroxYd, 450g Kochsalz und 4509 I-larnstoff zu Tabletten ä o,3 g.100 mg of thyroxine are mixed as the mono- or disodium salt with: 2o g of sodium salicylic acid. 100 tablets are pressed from the mixture. Example One bounces 9 g of thyroxine,. 9 g of sodium hydroxide, 450 g of table salt and 4509 of I-larnstoff in tablets of 0.3 g.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE575970T | 1930-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE575970C true DE575970C (en) | 1933-05-05 |
Family
ID=6569848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1930575970D Expired DE575970C (en) | 1930-12-09 | 1930-12-09 | Method for the preparation of masses for the preparation of thyroxine solutions which remain clear for a long time |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE575970C (en) |
-
1930
- 1930-12-09 DE DE1930575970D patent/DE575970C/en not_active Expired
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