DE545265C - Process for the preparation of 2-nitroacridine - Google Patents
Process for the preparation of 2-nitroacridineInfo
- Publication number
- DE545265C DE545265C DE1930545265D DE545265DD DE545265C DE 545265 C DE545265 C DE 545265C DE 1930545265 D DE1930545265 D DE 1930545265D DE 545265D D DE545265D D DE 545265DD DE 545265 C DE545265 C DE 545265C
- Authority
- DE
- Germany
- Prior art keywords
- nitroacridine
- preparation
- acridine
- sulfuric acid
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung von 2-Nitroacridin Bei der bekannten Nitrierung von Acridin mit heißer Salpetersäure bzw. Salpeter-Schwefelsäure in der Wärme entsteht ein Gemisch zweier Mononitroderivate und ein Dinitroderivat (vgl.Annalen 158 [1871] S. 275; Berichte 6o [z927] S. 137o).Process for the preparation of 2-nitroacridine In the known nitration from acridine with hot nitric acid or nitric-sulfuric acid in the heat a mixture of two mononitro derivatives and one dinitro derivative (see Annalen 158 [1871] P. 275; Reports 6o [z927] p. 137o).
Es wurde nun gefunden, daß man ein einheitliches Nitroacridin, und zwar das a-Nitroacridin, erhält, wenn man Acridin in konzentrierter Schwefelsäure bei Temperaturen unter 25° nitriert.It has now been found that a uniform nitroacridine, and a-nitroacridine is obtained when acridine is added to concentrated sulfuric acid nitrided at temperatures below 25 °.
Beispiel 17,9 Teile Acridin werden in Zoo Teilen konzentrierter Schwefelsäure gelöst, auf o° gekühlt und bei o bis 5 ° 13,8 Teile einer Nitriersäure, welche 43,6 °/o HNO., enthält, langsam zufließen gelassen. Nach Entfernung des Kühlmittels wird noch ungefähr 2 Stunden bei 15° gerührt, dasNitriergemisch dann in Eiswasser eingetragen, die Lösung filtriert und durch Zugabe von Natronlauge neutralisiert, wobei sich das gelbe 2-Nitroacridin abscheidet. Nach dem Absaugen, Auswaschen und Trocknen kristallisiert man es aus Chlorbenzol um und erhält goldgelbe Blättchen vom F. 216° in einer Ausbeute von 5 % der Theorie.EXAMPLE 17.9 parts of acridine are dissolved in zoo parts of concentrated sulfuric acid, cooled to 0 ° and 13.8 parts of a nitrating acid which contains 43.6% HNO., Are slowly allowed to flow in at 0 ° to 5 °. After removing the coolant, the mixture is stirred for about 2 hours at 15 °, the nitration mixture is then poured into ice water, the solution is filtered and neutralized by adding sodium hydroxide solution, the yellow 2-nitroacridine separating out. After suctioning off, washing out and drying, it is recrystallized from chlorobenzene and golden yellow flakes with a melting point of 216 ° are obtained in a yield of 5 % of theory.
Das erhaltene Nitroacridin kann in vielfacher technischer Hinsicht verwendet werden.The nitroacridine obtained can be used in many technical respects be used.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE545265T | 1930-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE545265C true DE545265C (en) | 1932-02-27 |
Family
ID=6560724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1930545265D Expired DE545265C (en) | 1930-12-23 | 1930-12-23 | Process for the preparation of 2-nitroacridine |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE545265C (en) |
-
1930
- 1930-12-23 DE DE1930545265D patent/DE545265C/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE545265C (en) | Process for the preparation of 2-nitroacridine | |
| DE485275C (en) | Process for the production of nitrogen-containing anthraquinone derivatives | |
| DE679279C (en) | Process for the preparation of a tetraalkylated dinitrobenzene | |
| DE615528C (en) | Process for the preparation of aminopyrene sulfonic acids | |
| AT112133B (en) | Process for the preparation of nitropyridinarsinic acids. | |
| DE812078C (en) | Process for the preparation of 4-nitro-1-amino-naphthalene-5-sulfonic acid | |
| DE245536C (en) | ||
| DE347375C (en) | Process for the preparation of nitro-3-quinolines | |
| DE512228C (en) | Process for the preparation of 2-halo-5-nitro-1,4-benzenedicarboxylic acids | |
| DE638601C (en) | Process for the preparation of anthraquinone dyes | |
| DE508694C (en) | Process for the preparation of triarylmethane dyes | |
| DE767510C (en) | Process for the preparation of 1, 3, 5-trichloro-2, 4, 6-trinitrobenzene | |
| DE701135C (en) | Process for the preparation of 1- (4'-nitrophenyl) -3-methyl-5-pyrazolone | |
| DE510435C (en) | Process for the preparation of negatively substituted carbazoles | |
| DE626788C (en) | Process for the preparation of pure 2-acetylamino-3-chloroanthraquinone | |
| DE495714C (en) | Process for the preparation of multiply halogen-substituted quinoline carboxylic acids | |
| DE417444C (en) | Process for the preparation of 3-amino-5 (?) - nitro-6-oxy-1-acetylbenzene | |
| DE740445C (en) | Process for the preparation of p, p-diaminodiphenyl sulfone | |
| DE510449C (en) | Process for the preparation of 6-oxybenzylamine-3-arsinic acids and their acyl derivatives | |
| DE523523C (en) | Process for the preparation of 1,2-diaminoanthraquinone | |
| DE397079C (en) | Process for the preparation of diarylantimony compounds | |
| DE476663C (en) | Process for the preparation of N-methylsulfurous acid salts of secondary aromatic-aliphatic amines | |
| AT162164B (en) | Process for the preparation of α, α-di (nitrophenyl) -β, β, β-trichloroethanes. | |
| DE527860C (en) | Process for the preparation of 1,5-dinitro-8-chloro- and 1,8-dinitro-4-chloroanthraquinone | |
| DE488605C (en) | Process for the preparation of tetranitrodianthrone |