DE524561C - Process for the preparation of a compound of humic acid with formaldehyde and ammonia - Google Patents
Process for the preparation of a compound of humic acid with formaldehyde and ammoniaInfo
- Publication number
- DE524561C DE524561C DEH115219D DEH0115219D DE524561C DE 524561 C DE524561 C DE 524561C DE H115219 D DEH115219 D DE H115219D DE H0115219 D DEH0115219 D DE H0115219D DE 524561 C DE524561 C DE 524561C
- Authority
- DE
- Germany
- Prior art keywords
- ammonia
- formaldehyde
- humic acid
- compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H99/00—Subject matter not provided for in other groups of this subclass, e.g. flours, kernels
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Verfahren zur Herstellung einer Verbindung von Huminsäure mit Formaldehyd und Ammoniak Die Erfindung betrifft ein Verfahren zur Herstellung einer Verbindung von Huminsäure mit Formaldehyd und Ammoniak, welche sich durch ein hohes Löslichkeitsvermögen für Harnsäure auszeichnet und für therapeutische Zwecke Verwendung finden soll.Process for the preparation of a compound of humic acid with formaldehyde and ammonia. The invention relates to a method of making a compound of humic acid with formaldehyde and ammonia, which are characterized by a high solubility for uric acid and is said to be used for therapeutic purposes.
Das Verfahren besteht im wesentlichen darin, daß man Huminsäure mit Formaldehyd im Lberschuß versetzt und alsdann der Flüssigkeit portionsweise unter Schütteln Ammoniak bis zur geringen übersättigung zufügt. Es resultiert eine Flüssigkeit, die beim langsamen Verdunsten auf Petrischalen bei Zimmertemperatur eine kristallinische Masse hinterläßt. Diese zeigt unter dem Mikroskop ein nadel- bzw. farnblattartiges Gefüge. In Wasser und Alkohol ist die Verbindung leicht löslich, während sie in Aceton, Benzol und Petroläther unlöslich ist. Der Schmelzpunkt liegt bei etwa zoo°. Beim Erhitzen über den Schmelzpunkt tritt unter Aufschäumen Zersetzung .ein.The process consists essentially in that one humic acid with Formaldehyde was added in excess and then added in portions to the liquid Shake ammonia until it is slightly oversaturated. The result is a liquid a crystalline one when evaporating slowly on Petri dishes at room temperature Leaves mass. Under the microscope this shows something like a needle or fern leaf Structure. The compound is easily soluble in water and alcohol, while in Acetone, benzene and petroleum ether are insoluble. The melting point is around zoo °. When heated above the melting point, decomposition occurs with foaming.
Bekanntlich bildet sich bei der Einwirkung von Ammoniak auf Formaldehyd Hexamethylentetramin, welches in kurzen sechsseitigen Säulen kristallisiert. Die vollkommen abweichende Kristallstruktur des nach dem obigen Verfahren erhaltenen Präparates zeigt, daß es sich um eine neue chemische Verbindung handelt, die durch Eintritt des Huminsäuremoleküls in die Hexamethylentetramingruppe entstanden ist. Hierfür sprechen auch die abweichenden chemischen, physikalischen und physiologischen Eigenschaften des neuen Körpers. Zur Herstellung des Präparates kann zahlenmäßig wie folgt verfahren werden: i kg Casselerbraun, welches zu 96 % aus Huminsäure und anderen Humusstoffen besteht, wird mit der doppelten Menge Formaldehydlösung übergossen und durch Schütteln fein aufgeschlemmt. Hierauf setzt man der Flüssigkeit unter weiterem Schütteln i,3 kg Ammoniak vom spezifischen Gewicht o,9io in kleinen Portionen so lange zu, bis eine vollständige Neutralisation eingetreten ist. Man übersättigt nun mit einer Spur von Ammoniak und setzt der Flüssigkeit etwa die Hälfte ihres Gewichts Wasser zu und ferner 96%igen Alkohol in einer Menge, die der Hälfte des Gesamtgewichts der ganzen Flüssigkeit entspricht. Man dickt hierauf die Flüssigkeit bei einer q.o bis 5o° nicht übersteigenden Temperatur zur Trockene ein. Die Ausbeute beträgt etwa 2 kg feste Substanz. Das Präparat kann leicht zerbröckelt und gepulvert werden und enthält einen hohen Prozentsatz der neuen Verbindung.It is known that the action of ammonia on formaldehyde forms hexamethylenetetramine, which crystallizes in short six-sided columns. The completely different crystal structure of the preparation obtained by the above process shows that it is a new chemical compound that has been formed by the entry of the humic acid molecule into the hexamethylenetetramine group. This is also supported by the different chemical, physical and physiological properties of the new body. To produce the preparation, the following procedure can be carried out numerically: 1 kg of Casseler's brown, which consists of 96% humic acid and other humus substances, is doused with twice the amount of formaldehyde solution and finely slurried by shaking. Then 1.3 kg of ammonia with a specific gravity of 0.3 kg are added to the liquid in small portions, with further shaking, until complete neutralization has taken place. One then over-saturates with a trace of ammonia and adds about half its weight of water to the liquid and also 96% alcohol in an amount which corresponds to half of the total weight of the whole liquid. The liquid is then thickened to dryness at a temperature not exceeding qo to 50 °. The yield is about 2 kg of solid substance. The preparation can be easily crumbled and powdered and contains a high percentage of the new compound.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEH115219D DE524561C (en) | 1928-02-12 | 1928-02-12 | Process for the preparation of a compound of humic acid with formaldehyde and ammonia |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEH115219D DE524561C (en) | 1928-02-12 | 1928-02-12 | Process for the preparation of a compound of humic acid with formaldehyde and ammonia |
Publications (1)
Publication Number | Publication Date |
---|---|
DE524561C true DE524561C (en) | 1931-05-07 |
Family
ID=7172248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEH115219D Expired DE524561C (en) | 1928-02-12 | 1928-02-12 | Process for the preparation of a compound of humic acid with formaldehyde and ammonia |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE524561C (en) |
-
1928
- 1928-02-12 DE DEH115219D patent/DE524561C/en not_active Expired
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