DE515545C - Process for the preparation of betaine rhodanide - Google Patents
Process for the preparation of betaine rhodanideInfo
- Publication number
- DE515545C DE515545C DEI31542D DEI0031542D DE515545C DE 515545 C DE515545 C DE 515545C DE I31542 D DEI31542 D DE I31542D DE I0031542 D DEI0031542 D DE I0031542D DE 515545 C DE515545 C DE 515545C
- Authority
- DE
- Germany
- Prior art keywords
- betaine
- rhodanide
- weight
- parts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Es wurde gefunden, daß man durch Vereinigung von Betain (Trimethylglykokoll) mit Rhodanwasserstoffsäure oder durch Umsetzung von Betainsalzen mit geeigneten Salzen der Rhodanwasserstoffsäure zum Betainrhodanid gelangt.It has been found that by combining betaine (trimethyl glycol) with Rhodanic acid or by reacting betaine salts with suitable salts of the Rhodanic acid reaches the betaine rhodanide.
Diese Verbindung hat wertvolle Vorzüge vor den bekannten, in der Therapie verwendeten Verbindungen der Rhodanwasserstoffsäure, dennThis compound has valuable advantages over the known ones used in therapy Compounds of hydrofluoric acid, because
ίο einerseits kommt in ihr die reine Wirkung dieser Säure zur Auswertung, da das Betain zum Teil vom Organismus verbrannt, zum Teil unverändert ausgeschieden wird, anderseits wird außer der Kochsalz- auch die Harnstoffausscheidung des Körpers erheblich gesteigert, was bei manchen Erkrankungen von Wert ist.On the one hand, the pure effect of this comes in it Acid for evaluation, since the betaine is partly burned by the organism, partly unchanged is excreted, on the other hand, in addition to table salt, urea is also excreted of the body is significantly increased, which is of value in some diseases.
Beispiel ιExample ι
135 Gewichtsteile kristallisiertes Betain oder 117 Gewichtsteile wasserfreies Betain werden unter Rühren in 480 Gewichtsteilen wäßriger Rhodanwasserstoffsäure mit einem Gehalt von 8,3 % Rhodanwasserstoff gelöst. Die Lösung wird abgekühlt, wobei ein Teil des Betainrhodanids auskristallisiert. Nachdem vom Auskristallisierten abgesaugt ist, wird die Mutterlauge im Vakuum bei einer 100 ° nicht übersteigenden Temperatur auf ein kleines Volumen eingedampft, abgekühlt und nochmals abgesaugt. Durch Umkristallisieren aus Alkohol oder Wasser wird das Betainrhodanid völlig rein erhalten. Es schmilzt bei 167 ° unter Zersetzung. 135 parts by weight of crystallized betaine or 117 parts by weight of anhydrous betaine will be with stirring in 480 parts by weight of aqueous hydrothodanic acid containing 8.3% dissolved hydrogen rhodanide. The solution is cooled, with some of the betaine rhodanide crystallized out. After the crystallized material has been filtered off with suction, the mother liquor becomes in a vacuum at a temperature not exceeding 100 ° to a small volume evaporated, cooled and sucked off again. By recrystallizing from alcohol or water, the betaine rhodanide is kept completely pure. It melts at 167 ° with decomposition.
76 Gewichtsteile Ammoniumrhodanid werden in 33 Gewichtsteilen Wasser heiß gelöst, worauf die Lösung mit einer kochend heißen Lösung von 153,5 Gewichtsteilen Betainhydrochlorid in 200 Gewichtsteilen Wasser vermischt wird. Nach dem Erkalten wird das auskristallisierte Betainrhodanid abgesaugt. Das Rohprodukt wird von etwa noch beigemengten geringen Mengen Ammoniumchlorid durch Auswaschen mit Alkohol oder Umkristallisieren aus Wasser befreit.76 parts by weight of ammonium rhodanide are dissolved in 33 parts by weight of hot water, whereupon the solution with a boiling hot solution of 153.5 parts by weight of betaine hydrochloride in 200 parts by weight of water is mixed. After cooling, the crystallized betaine rhodanide becomes sucked off. The crude product is made from small amounts of ammonium chloride that are still added by washing with alcohol or recrystallization from water.
76 Gewichtsteile Ammoniumrhodanid werden in 150 Gewichtsteilen Alkohol heiß gelöst. Die Lösung wird mit einer heiß bereiteten Lösung von 153,5 Gewichtsteilen Betainhydrochlorid in 150 Gewichtsteilen Wasser vermischt, worauf beim Erkalten das Betainrhodanid auskristallisiert. Die Reinigung erfolgt wie in Beispiel 2.76 parts by weight of ammonium thiocyanate are dissolved in 150 parts by weight of hot alcohol. the Solution is prepared with a hot solution of 153.5 parts by weight betaine hydrochloride in 150 parts by weight of water mixed, whereupon the betaine rhodanide crystallizes out on cooling. The cleaning is carried out as in example 2.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI31542D DE515545C (en) | 1927-06-29 | 1927-06-29 | Process for the preparation of betaine rhodanide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI31542D DE515545C (en) | 1927-06-29 | 1927-06-29 | Process for the preparation of betaine rhodanide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE515545C true DE515545C (en) | 1931-01-08 |
Family
ID=7187906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEI31542D Expired DE515545C (en) | 1927-06-29 | 1927-06-29 | Process for the preparation of betaine rhodanide |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE515545C (en) |
-
1927
- 1927-06-29 DE DEI31542D patent/DE515545C/en not_active Expired
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