DE4318369C1 - Verwendung von makrocyclischen Metallkomplexen als Temperatursonden - Google Patents

Verwendung von makrocyclischen Metallkomplexen als Temperatursonden

Info

Publication number
DE4318369C1
DE4318369C1 DE4318369A DE4318369A DE4318369C1 DE 4318369 C1 DE4318369 C1 DE 4318369C1 DE 4318369 A DE4318369 A DE 4318369A DE 4318369 A DE4318369 A DE 4318369A DE 4318369 C1 DE4318369 C1 DE 4318369C1
Authority
DE
Germany
Prior art keywords
complex
tris
mmol
temperature
carboxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE4318369A
Other languages
German (de)
English (en)
Inventor
Johannes Dr Platzek
Bernd Dr Raduechel
Ulrich Dr Niedballa
Hanns-Joachim Dr Weinmann
Hans Dr Bauer
Klaus Prof Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE4318369A priority Critical patent/DE4318369C1/de
Application filed by Schering AG filed Critical Schering AG
Priority to EP94915565A priority patent/EP0700392B1/de
Priority to JP7500147A priority patent/JPH08511247A/ja
Priority to PCT/EP1994/001376 priority patent/WO1994027977A1/de
Priority to DE59407453T priority patent/DE59407453D1/de
Priority to CA002163763A priority patent/CA2163763A1/en
Priority to AT94915565T priority patent/ATE174331T1/de
Priority to US08/549,803 priority patent/US5747000A/en
Application granted granted Critical
Publication of DE4318369C1 publication Critical patent/DE4318369C1/de
Priority to NO954830A priority patent/NO300377B1/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE4318369A 1993-05-28 1993-05-28 Verwendung von makrocyclischen Metallkomplexen als Temperatursonden Expired - Lifetime DE4318369C1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE4318369A DE4318369C1 (de) 1993-05-28 1993-05-28 Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
JP7500147A JPH08511247A (ja) 1993-05-28 1994-04-29 温度探査子としての大環状金属錯体の利用
PCT/EP1994/001376 WO1994027977A1 (de) 1993-05-28 1994-04-29 Verwendung von makrocyclischen metallkomplexen als temperatursonden
DE59407453T DE59407453D1 (de) 1993-05-28 1994-04-29 Verwendung von makrocyclischen metallkomplexen als temperatursonden
EP94915565A EP0700392B1 (de) 1993-05-28 1994-04-29 Verwendung von makrocyclischen metallkomplexen als temperatursonden
CA002163763A CA2163763A1 (en) 1993-05-28 1994-04-29 Use of macrocyclic metal complexes as temperature probes
AT94915565T ATE174331T1 (de) 1993-05-28 1994-04-29 Verwendung von makrocyclischen metallkomplexen als temperatursonden
US08/549,803 US5747000A (en) 1993-05-28 1994-04-29 Use of macrocyclic metal complexes as temperature sensors
NO954830A NO300377B1 (no) 1993-05-28 1995-11-28 Anvendelse av makrosykliske metallkomplekser som temperatursonder

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4318369A DE4318369C1 (de) 1993-05-28 1993-05-28 Verwendung von makrocyclischen Metallkomplexen als Temperatursonden

Publications (1)

Publication Number Publication Date
DE4318369C1 true DE4318369C1 (de) 1995-02-09

Family

ID=6489487

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4318369A Expired - Lifetime DE4318369C1 (de) 1993-05-28 1993-05-28 Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
DE59407453T Expired - Lifetime DE59407453D1 (de) 1993-05-28 1994-04-29 Verwendung von makrocyclischen metallkomplexen als temperatursonden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59407453T Expired - Lifetime DE59407453D1 (de) 1993-05-28 1994-04-29 Verwendung von makrocyclischen metallkomplexen als temperatursonden

Country Status (8)

Country Link
US (1) US5747000A (no)
EP (1) EP0700392B1 (no)
JP (1) JPH08511247A (no)
AT (1) ATE174331T1 (no)
CA (1) CA2163763A1 (no)
DE (2) DE4318369C1 (no)
NO (1) NO300377B1 (no)
WO (1) WO1994027977A1 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019038428A2 (de) 2017-08-25 2019-02-28 Christian-Albrechts-Universität Zu Kiel Neuartiges mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung

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IT1265440B1 (it) * 1993-12-24 1996-11-22 Bracco Spa Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse
IT1291624B1 (it) 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
EP1069888B1 (en) * 1998-04-09 2004-09-22 Amersham Health AS Use of particulate contrast agents in diagnostic imaging for studying physiological parameters
DE19816917A1 (de) * 1998-04-16 1999-10-28 Siemens Ag Verfahren zur räumlich aufgelösten Temperaturüberwachung, Suspension von ferromagnetischen Mikropartikeln und Verwendung dieser Suspension
GB9823175D0 (en) * 1998-10-22 1998-12-16 Nycomed Imaging As Compound
US6342598B1 (en) * 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
US6132958A (en) * 1999-05-27 2000-10-17 The Rockefeller University Fluorescent bead for determining the temperature of a cell and methods of use thereof
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
CN101090739B (zh) * 2004-07-02 2012-10-10 伯拉考成像股份公司 磁共振成像中用作高弛豫造影剂配体的1，4-二（羧甲基）氨基-6-甲基-全氢-1，4-二氮杂*（aazta)衍生物
EP3386954B1 (en) * 2015-12-10 2020-12-02 Bracco Imaging SpA Dimeric contrast agents
PT3519394T (pt) 2016-09-27 2020-08-03 Bayer Pharma AG Método para produzir a forma cristalina de modificação a de calcobutrol

Citations (8)

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Publication number Priority date Publication date Assignee Title
DE3401052A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Diagnostische mittel
EP0255371A1 (en) * 1986-08-01 1988-02-03 Ici Americas Inc. Polyureas prepared from a mixture of polyamines and a polyisocyanate
EP0299795A2 (en) * 1987-07-16 1989-01-18 Nycomed As Aminopolycarboxylic acids and derivatives thereof
EP0413405A2 (de) * 1989-08-16 1991-02-20 Schering Aktiengesellschaft Verwendung von Amid-Komplexverbindungen
EP0434346A1 (en) * 1989-12-22 1991-06-26 E.R. SQUIBB & SONS, INC. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane
EP0434345A1 (en) * 1989-12-22 1991-06-26 E.R. SQUIBB & SONS, INC. 10-(2'-hydroxy-3'-alkoxy)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecanes
EP0450742A1 (de) * 1990-04-06 1991-10-09 Schering Aktiengesellschaft DTPA-Monoamide, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen

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US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4558279A (en) * 1983-03-07 1985-12-10 University Of Cincinnati Methods for detecting and imaging a temperature of an object by nuclear magnetic resonance
US4767611A (en) * 1984-07-03 1988-08-30 Gordon Robert T Method for affecting intracellular and extracellular electric and magnetic dipoles
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds
US5236694A (en) * 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2672051B1 (fr) * 1991-01-24 1993-05-21 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique.
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5490840A (en) * 1994-09-26 1996-02-13 General Electric Company Targeted thermal release of drug-polymer conjugates

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3401052A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Diagnostische mittel
EP0255371A1 (en) * 1986-08-01 1988-02-03 Ici Americas Inc. Polyureas prepared from a mixture of polyamines and a polyisocyanate
EP0299795A2 (en) * 1987-07-16 1989-01-18 Nycomed As Aminopolycarboxylic acids and derivatives thereof
EP0413405A2 (de) * 1989-08-16 1991-02-20 Schering Aktiengesellschaft Verwendung von Amid-Komplexverbindungen
EP0434346A1 (en) * 1989-12-22 1991-06-26 E.R. SQUIBB & SONS, INC. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane
EP0434345A1 (en) * 1989-12-22 1991-06-26 E.R. SQUIBB & SONS, INC. 10-(2'-hydroxy-3'-alkoxy)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecanes
EP0450742A1 (de) * 1990-04-06 1991-10-09 Schering Aktiengesellschaft DTPA-Monoamide, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen

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Title
BERKOWITZ, B.A., MANDA, J. T., WILSON, C.A.: NMR in Biomedicine 5, 65 (1992) *
COMBRISSON, S., PRANGE, T.: J. Magn. Res. 19, 108 (1973) *
J. Chem. Soc. Perkin Trans. I, 12, p. 3329, (1991) *
SCHNEIDER, M.J., FREITAG, W., SCHOMMER, M.: J. Magn. Res. 18, 393 (1973) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019038428A2 (de) 2017-08-25 2019-02-28 Christian-Albrechts-Universität Zu Kiel Neuartiges mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung
DE102017119482A1 (de) 2017-08-25 2019-02-28 Christian-Albrechts-Universität Zu Kiel Neuartiges MRT-Kontrastmittel, Verwendung zur Temperaturmessung und Verfahren zur Temperaturmessung

Also Published As

Publication number Publication date
NO954830D0 (no) 1995-11-28
US5747000A (en) 1998-05-05
DE59407453D1 (de) 1999-01-21
EP0700392B1 (de) 1998-12-09
CA2163763A1 (en) 1994-12-08
NO954830L (no) 1995-11-28
JPH08511247A (ja) 1996-11-26
EP0700392A1 (de) 1996-03-13
NO300377B1 (no) 1997-05-20
WO1994027977A1 (de) 1994-12-08
ATE174331T1 (de) 1998-12-15

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8330 Complete renunciation