DE406867C - Process for the preparation of easily soluble organic bismuth compounds - Google Patents
Process for the preparation of easily soluble organic bismuth compoundsInfo
- Publication number
- DE406867C DE406867C DER57306D DER0057306D DE406867C DE 406867 C DE406867 C DE 406867C DE R57306 D DER57306 D DE R57306D DE R0057306 D DER0057306 D DE R0057306D DE 406867 C DE406867 C DE 406867C
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- soluble organic
- easily soluble
- compounds
- organic bismuth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 4
- 150000001622 bismuth compounds Chemical class 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- 150000001621 bismuth Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 239000000084 colloidal system Substances 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000007857 degradation product Substances 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 108010010803 Gelatin Proteins 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- RXPAJWPEYBDXOG-UHFFFAOYSA-N hydron;methyl 4-methoxypyridine-2-carboxylate;chloride Chemical compound Cl.COC(=O)C1=CC(OC)=CC=N1 RXPAJWPEYBDXOG-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229940049676 bismuth hydroxide Drugs 0.000 description 1
- TZSXPYWRDWEXHG-UHFFFAOYSA-K bismuth;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Bi+3] TZSXPYWRDWEXHG-UHFFFAOYSA-K 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Darstellung leicht löslicher organischer Wismutverbindungen. Die Wismutsalze der Oxymercurisalicylsäure und ihrer Derivate stellen in Wasser unlösliche Verbindungen vor. Für therapeutische Zwecke ist es aber wünschenswert, sie in wasserlöslicher Form zu erhalten.Process for the preparation of easily soluble organic bismuth compounds. The bismuth salts of oxymercurisalicylic acid and its derivatives put in water insoluble compounds. For therapeutic purposes, however, it is desirable to get them in water-soluble form.
Gegenstand der vorliegenden Erfindung ist ein Verfahren, durch: welches dieses Ziel erreicht wird. Dies ist nämlich möglich, indem man. die Verbindungen in Gegenwart von Eiweißstoffen oder deren Abbauprodukten, insbesondere von Spaltungsprodukten der Gelatine, erzeugt oder die frisch gefällten Salze mit Lösungen dieser Schutzkolloide behandelt. Man erhält auf diese Weise trotz der bekannten Neigung der Wismutsalze, mit Wasser basische unlösliche Salze abzuscheiden, :haltbare Lösungen, aus denen man beim Eindunsten oder beim Versetzen mit organischen Lösungsmitteln, z. B. Aceton oder Alkohol, die Verbindungen in fester Form gewinnen kann. Sie stellen schwach gefärbte Produkte vor, die mit Wasser wieder restlos in Lösung gehen, worauf man in der Durchsicht klare, im auffallenden Licht milchigtrübe Lösungen erhält.The present invention is a method by: which this goal is achieved. Namely, this is possible by. the connections in the presence of proteins or their breakdown products, in particular of decomposition products the gelatine, or the freshly precipitated salts with solutions of these protective colloids treated. In this way, despite the known tendency of the bismuth salts, to deposit insoluble salts with basic water: durable solutions from which when evaporating or when adding organic solvents such. B. acetone or alcohol, which can extract compounds in solid form. They make weak colored products that go completely back into solution with water, whereupon one Obtains clear solutions when viewed through, and milky solutions when viewed from the light.
Beispiel i.Example i.
17 Teile Oxymercurisalicylsäureanlzydrid werden unter Zusatz von Natronlauge in Wasser gelöst und mit einer aus 17o Teilen Gelatine durch: Aufspaltung mit Salzsäure gewonnenen. neutralisierten, Gelatinelösung versetzt. Man gibt nun unter Rühren allmählich eine konzentrierte wäßrige glycerinhaltige Lösung von 8,5 Teilen Wismutnitrat zu, wobei keine oder nur eine sofort wieder verschwindende Ausfällung eintritt. Aus der Lösung gewinnt man, gegebenenfalls nach vorherigem Dialysieren, durch: vorsichtiges Eindunsten das . Wismutsalz der Oxymercurisalicylsäure in Form einer anscheinend komplexen Verbindung in Gestalt von Lamellen, die. reit MTasser wieder leicht in Lösung zu bringen sind.17 parts of Oxymercurisalicylsäureanlzydrid are with the addition of caustic soda dissolved in water and treated with a gelatin of 170 parts by: splitting with hydrochloric acid won. neutralized, gelatin solution added. It is now added with stirring gradually a concentrated aqueous glycerol-containing solution of 8.5 parts of bismuth nitrate to, with no precipitation or only one which immediately disappears again. The solution is obtained, if necessary after previous dialysis, by: careful Evaporate that. Bismuth salt of oxymercuric salicylic acid in the form of an apparently complex connection in the form of slats that. MTasser easily rides in again Solution are to be brought.
Beispiel e.Example e.
Man löst 44 Teile cyanmercurisalicylsaures Kalium in einer aus 3 oo g Gelatine durch Hydrolyse mit Wasser dargestellten wäßrigen Gelatöse und versetzt diese Lösung mit aus 17 Teilen Wismutnitrat frisch dargestelltem Wismuthydroxyd. Es entsteht eine im auffallenden Licht milchige, im durchfallenden Licht klare Lösung. Versetzt man diese mit Aceton, so erhält man eine Fällung, welche nach Abtrennung von des Lösung mit Aceton gewaschen wird. Auch dieses Produkt ist nach dem Trocknen in Wasser löslich.44 parts of potassium cyanohydric salicylate are dissolved in one of 3,000 g of gelatin prepared by hydrolysis with water and added to aqueous gelatin this solution with bismuth hydroxide freshly prepared from 17 parts of bismuth nitrate. The result is a milky solution in incident light and clear in transmitted light. If this is mixed with acetone, a precipitate is obtained, which after separation is washed from the solution with acetone. This product is also after drying soluble in water.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DER57306D DE406867C (en) | 1922-12-01 | 1922-12-01 | Process for the preparation of easily soluble organic bismuth compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DER57306D DE406867C (en) | 1922-12-01 | 1922-12-01 | Process for the preparation of easily soluble organic bismuth compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE406867C true DE406867C (en) | 1924-11-29 |
Family
ID=7410493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DER57306D Expired DE406867C (en) | 1922-12-01 | 1922-12-01 | Process for the preparation of easily soluble organic bismuth compounds |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE406867C (en) |
-
1922
- 1922-12-01 DE DER57306D patent/DE406867C/en not_active Expired
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