DE4040874A1 - Lipolytische enzyminhibitoren und sie enthaltende diaetische agentien und lebensmittel- und futterzusaetze - Google Patents
Lipolytische enzyminhibitoren und sie enthaltende diaetische agentien und lebensmittel- und futterzusaetzeInfo
- Publication number
- DE4040874A1 DE4040874A1 DE4040874A DE4040874A DE4040874A1 DE 4040874 A1 DE4040874 A1 DE 4040874A1 DE 4040874 A DE4040874 A DE 4040874A DE 4040874 A DE4040874 A DE 4040874A DE 4040874 A1 DE4040874 A1 DE 4040874A1
- Authority
- DE
- Germany
- Prior art keywords
- inhibiting substance
- lysine
- basic
- poly
- purothionin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000002366 lipolytic effect Effects 0.000 title claims description 19
- 239000003795 chemical substances by application Substances 0.000 title claims description 14
- 235000013305 food Nutrition 0.000 title claims description 6
- 239000003674 animal food additive Substances 0.000 title claims description 4
- 239000002778 food additive Substances 0.000 title claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 230000002401 inhibitory effect Effects 0.000 claims description 26
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 22
- 239000004472 Lysine Substances 0.000 claims description 21
- 229960003646 lysine Drugs 0.000 claims description 21
- 229920001184 polypeptide Polymers 0.000 claims description 20
- 102000004169 proteins and genes Human genes 0.000 claims description 20
- 108090000623 proteins and genes Proteins 0.000 claims description 20
- 229920000656 polylysine Polymers 0.000 claims description 18
- 239000003112 inhibitor Substances 0.000 claims description 16
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 claims description 14
- 238000006116 polymerization reaction Methods 0.000 claims description 14
- 102000004190 Enzymes Human genes 0.000 claims description 13
- 108090000790 Enzymes Proteins 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 108010039918 Polylysine Proteins 0.000 claims description 10
- 239000002532 enzyme inhibitor Substances 0.000 claims description 10
- 108010033040 Histones Proteins 0.000 claims description 9
- 235000005911 diet Nutrition 0.000 claims description 9
- 230000000378 dietary effect Effects 0.000 claims description 9
- 108010026134 purothionin Proteins 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 8
- 230000000996 additive effect Effects 0.000 claims description 8
- 102000007327 Protamines Human genes 0.000 claims description 7
- 108010007568 Protamines Proteins 0.000 claims description 7
- 229940048914 protamine Drugs 0.000 claims description 7
- 229920001347 α-poly-L-lysine Polymers 0.000 claims description 7
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims description 6
- 102000006947 Histones Human genes 0.000 claims description 5
- 229920001338 α-poly-D-lysine Polymers 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 229940125532 enzyme inhibitor Drugs 0.000 claims description 4
- 108010011110 polyarginine Proteins 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims 16
- 150000001412 amines Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 description 45
- 239000000839 emulsion Substances 0.000 description 32
- 230000000694 effects Effects 0.000 description 25
- 238000002360 preparation method Methods 0.000 description 25
- 239000004367 Lipase Substances 0.000 description 20
- 108090001060 Lipase Proteins 0.000 description 19
- 102000004882 Lipase Human genes 0.000 description 19
- 229940040461 lipase Drugs 0.000 description 19
- 235000019421 lipase Nutrition 0.000 description 19
- 235000018102 proteins Nutrition 0.000 description 17
- 239000000758 substrate Substances 0.000 description 15
- 229940116369 pancreatic lipase Drugs 0.000 description 14
- 108050006759 Pancreatic lipases Proteins 0.000 description 13
- 102000019280 Pancreatic lipases Human genes 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 239000013068 control sample Substances 0.000 description 11
- 229940088598 enzyme Drugs 0.000 description 11
- 239000004006 olive oil Substances 0.000 description 11
- 235000008390 olive oil Nutrition 0.000 description 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 10
- 150000002632 lipids Chemical class 0.000 description 10
- 235000018977 lysine Nutrition 0.000 description 10
- 108010055297 Sterol Esterase Proteins 0.000 description 7
- 102000000019 Sterol Esterase Human genes 0.000 description 7
- 239000007983 Tris buffer Substances 0.000 description 7
- 239000003613 bile acid Substances 0.000 description 7
- 239000008057 potassium phosphate buffer Substances 0.000 description 7
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 7
- 235000019766 L-Lysine Nutrition 0.000 description 6
- 102000008192 Lactoglobulins Human genes 0.000 description 6
- 108010060630 Lactoglobulins Proteins 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 101000693922 Bos taurus Albumin Proteins 0.000 description 5
- 108010058846 Ovalbumin Proteins 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 235000019626 lipase activity Nutrition 0.000 description 5
- 229940092253 ovalbumin Drugs 0.000 description 5
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 150000001413 amino acids Chemical group 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229940086609 Lipase inhibitor Drugs 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 3
- RJECHNNFRHZQKU-UHFFFAOYSA-N Oelsaeurecholesterylester Natural products C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCC=CCCCCCCCC)C2 RJECHNNFRHZQKU-UHFFFAOYSA-N 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- RJECHNNFRHZQKU-RMUVNZEASA-N cholesteryl oleate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)C1 RJECHNNFRHZQKU-RMUVNZEASA-N 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 235000021588 free fatty acids Nutrition 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 3
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229920001351 ε-poly-L-lysine Polymers 0.000 description 3
- PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical compound [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000031891 intestinal absorption Effects 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- STTGYIUESPWXOW-UHFFFAOYSA-N 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline Chemical compound C=12C=CC3=C(C=4C=CC=CC=4)C=C(C)N=C3C2=NC(C)=CC=1C1=CC=CC=C1 STTGYIUESPWXOW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229940119495 Cholesterol esterase inhibitor Drugs 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000017286 Histone H2A Human genes 0.000 description 1
- 108050005231 Histone H2A Proteins 0.000 description 1
- 229940127470 Lipase Inhibitors Drugs 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 101001134452 Sus scrofa Pancreatic triacylglycerol lipase Proteins 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 235000021434 dietary agent Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940070376 protein Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 201000009482 yaws Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33288489 | 1989-12-25 | ||
| JP7560090 | 1990-03-27 | ||
| JP2194782A JP2960947B2 (ja) | 1989-12-25 | 1990-07-25 | 脂質分解酵素阻害剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE4040874A1 true DE4040874A1 (de) | 1991-06-27 |
Family
ID=27301886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4040874A Ceased DE4040874A1 (de) | 1989-12-25 | 1990-12-20 | Lipolytische enzyminhibitoren und sie enthaltende diaetische agentien und lebensmittel- und futterzusaetze |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE4040874A1 (enExample) |
| FR (1) | FR2656311A1 (enExample) |
| GB (1) | GB2239455B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0589105A1 (en) * | 1991-04-08 | 1994-03-30 | Ohta's Isan Co., Ltd. | Improvement in livestock raising |
| EP0575846A3 (de) * | 1992-06-24 | 1994-12-21 | Hoffmann La Roche | Lipasehemmer enthaltende Nahrungsmittel und Futtermittel. |
| EP0631727A1 (en) * | 1993-06-25 | 1995-01-04 | Yakurigaku Chuo Kenkyusho | Lipase inhibitor derived from a defatted rice germ |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2758724B1 (fr) * | 1997-01-24 | 1999-04-23 | Javenech | Composition topique a base de protamine pour le traitement de la cellulite et des surcharges ponderales |
| JPWO2009107660A1 (ja) * | 2008-02-25 | 2011-07-07 | 味の素株式会社 | 糖尿病又は肥満病の予防又は治療剤 |
| CN117003845B (zh) * | 2022-12-26 | 2024-03-29 | 中国农业大学 | 小米醇溶蛋白肽及其在治疗高脂血症中的用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0288965A2 (de) * | 1987-04-29 | 1988-11-02 | Hoechst Aktiengesellschaft | Peptide mit Phospholipase A2- hemmender Wirkung |
-
1990
- 1990-12-17 GB GB9027268A patent/GB2239455B/en not_active Expired - Fee Related
- 1990-12-20 DE DE4040874A patent/DE4040874A1/de not_active Ceased
- 1990-12-21 FR FR9016069A patent/FR2656311A1/fr active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0589105A1 (en) * | 1991-04-08 | 1994-03-30 | Ohta's Isan Co., Ltd. | Improvement in livestock raising |
| EP0575846A3 (de) * | 1992-06-24 | 1994-12-21 | Hoffmann La Roche | Lipasehemmer enthaltende Nahrungsmittel und Futtermittel. |
| US5447953A (en) * | 1992-06-24 | 1995-09-05 | Hoffmann-La Roche Inc. | Biomasses to treat non-human animals |
| EP0631727A1 (en) * | 1993-06-25 | 1995-01-04 | Yakurigaku Chuo Kenkyusho | Lipase inhibitor derived from a defatted rice germ |
| US5503831A (en) * | 1993-06-25 | 1996-04-02 | Yakurigaku Chuo Kenkyusho | Lipase inhibitor derived from a defatted rice germ |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2239455A (en) | 1991-07-03 |
| GB2239455B (en) | 1993-12-15 |
| GB9027268D0 (en) | 1991-02-06 |
| FR2656311A1 (fr) | 1991-06-28 |
| FR2656311B1 (enExample) | 1995-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8127 | New person/name/address of the applicant |
Owner name: NISSHIN SEIFUN GROUP INC., TOKIO/TOKYO, JP |
|
| 8131 | Rejection |