DE4040056A1 - Saeureamide - Google Patents

Saeureamide

Info

Publication number
DE4040056A1
DE4040056A1 DE4040056A DE4040056A DE4040056A1 DE 4040056 A1 DE4040056 A1 DE 4040056A1 DE 4040056 A DE4040056 A DE 4040056A DE 4040056 A DE4040056 A DE 4040056A DE 4040056 A1 DE4040056 A1 DE 4040056A1
Authority
DE
Germany
Prior art keywords
amino
alkyl
methyl
phe
diol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4040056A
Other languages
German (de)
English (en)
Inventor
Horst Dr Juraszyk
Claus J Dr Schmitges
Klaus-Otto Dr Minck
Peter Dr Raddatz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE4040056A priority Critical patent/DE4040056A1/de
Priority to EP19910120848 priority patent/EP0490259A3/de
Priority to AU89614/91A priority patent/AU8961491A/en
Priority to TW080109734A priority patent/TW205505B/zh
Priority to CS913775A priority patent/CS377591A3/cs
Priority to CA002057534A priority patent/CA2057534A1/en
Priority to PT99810A priority patent/PT99810A/pt
Priority to ZA919851A priority patent/ZA919851B/xx
Priority to HU913942A priority patent/HUT62012A/hu
Priority to JP3360893A priority patent/JPH0733724A/ja
Priority to IE435991A priority patent/IE914359A1/en
Priority to KR1019910022878A priority patent/KR920012109A/ko
Publication of DE4040056A1 publication Critical patent/DE4040056A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE4040056A 1990-12-14 1990-12-14 Saeureamide Withdrawn DE4040056A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE4040056A DE4040056A1 (de) 1990-12-14 1990-12-14 Saeureamide
EP19910120848 EP0490259A3 (en) 1990-12-14 1991-12-04 Aminoacid and peptid derivatives with renin inhibiting properties
AU89614/91A AU8961491A (en) 1990-12-14 1991-12-11 Acid amides
TW080109734A TW205505B (https=) 1990-12-14 1991-12-11
CS913775A CS377591A3 (en) 1990-12-14 1991-12-12 Acid amides, process of their preparation and pharmaceutical compositionsbased thereon
CA002057534A CA2057534A1 (en) 1990-12-14 1991-12-12 Acid amides
PT99810A PT99810A (pt) 1990-12-14 1991-12-13 Processo para a preparacao de amidas de amino cidos substituidos
ZA919851A ZA919851B (en) 1990-12-14 1991-12-13 Acid amides
HU913942A HUT62012A (en) 1990-12-14 1991-12-13 Process for producing acid amides and peptides
JP3360893A JPH0733724A (ja) 1990-12-14 1991-12-13 酸アミド
IE435991A IE914359A1 (en) 1990-12-14 1991-12-13 Acid amides
KR1019910022878A KR920012109A (ko) 1990-12-14 1991-12-13 산 아미드 유도체

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4040056A DE4040056A1 (de) 1990-12-14 1990-12-14 Saeureamide

Publications (1)

Publication Number Publication Date
DE4040056A1 true DE4040056A1 (de) 1992-06-17

Family

ID=6420387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4040056A Withdrawn DE4040056A1 (de) 1990-12-14 1990-12-14 Saeureamide

Country Status (12)

Country Link
EP (1) EP0490259A3 (https=)
JP (1) JPH0733724A (https=)
KR (1) KR920012109A (https=)
AU (1) AU8961491A (https=)
CA (1) CA2057534A1 (https=)
CS (1) CS377591A3 (https=)
DE (1) DE4040056A1 (https=)
HU (1) HUT62012A (https=)
IE (1) IE914359A1 (https=)
PT (1) PT99810A (https=)
TW (1) TW205505B (https=)
ZA (1) ZA919851B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09177352A (ja) * 1995-12-25 1997-07-08 Harumi Onishi 駐車装置
CA2785673C (en) 2009-12-28 2015-07-21 Mitsubishi Gas Chemical Company, Inc. Polyamide compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
CA2023099A1 (en) * 1989-09-04 1991-03-05 Quirico Branca Amino acid derivatives

Also Published As

Publication number Publication date
CS377591A3 (en) 1992-09-16
AU8961491A (en) 1992-06-18
HUT62012A (en) 1993-03-29
KR920012109A (ko) 1992-07-25
EP0490259A2 (de) 1992-06-17
IE914359A1 (en) 1992-06-17
HU913942D0 (en) 1992-02-28
PT99810A (pt) 1992-12-31
JPH0733724A (ja) 1995-02-03
EP0490259A3 (en) 1993-05-12
TW205505B (https=) 1993-05-11
CA2057534A1 (en) 1992-06-15
ZA919851B (en) 1992-09-30

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee