DE3888404D1 - Verfahren zur Unterdrückung des thermischen Abbaus der Urokinase. - Google Patents

Verfahren zur Unterdrückung des thermischen Abbaus der Urokinase.

Info

Publication number
DE3888404D1
DE3888404D1 DE88305555T DE3888404T DE3888404D1 DE 3888404 D1 DE3888404 D1 DE 3888404D1 DE 88305555 T DE88305555 T DE 88305555T DE 3888404 T DE3888404 T DE 3888404T DE 3888404 D1 DE3888404 D1 DE 3888404D1
Authority
DE
Germany
Prior art keywords
urokinase
suppressing
thermal degradation
degradation
thermal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88305555T
Other languages
English (en)
Other versions
DE3888404T2 (de
Inventor
Hajime Hiratani
Satoshi Nishimuro
Koichiro Nakanishi
Masaichi Ota
Hiroshi Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Original Assignee
JCR Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd filed Critical JCR Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of DE3888404D1 publication Critical patent/DE3888404D1/de
Publication of DE3888404T2 publication Critical patent/DE3888404T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DE3888404T 1987-06-18 1988-06-17 Verfahren zur Unterdrückung des thermischen Abbaus der Urokinase. Expired - Fee Related DE3888404T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62153043A JP2545231B2 (ja) 1987-06-18 1987-06-18 ウロキナ−ゼの加熱による低分子化抑制法

Publications (2)

Publication Number Publication Date
DE3888404D1 true DE3888404D1 (de) 1994-04-21
DE3888404T2 DE3888404T2 (de) 1994-06-30

Family

ID=15553722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888404T Expired - Fee Related DE3888404T2 (de) 1987-06-18 1988-06-17 Verfahren zur Unterdrückung des thermischen Abbaus der Urokinase.

Country Status (4)

Country Link
US (1) US4946785A (de)
EP (1) EP0295940B1 (de)
JP (1) JP2545231B2 (de)
DE (1) DE3888404T2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405767A (en) * 1992-04-08 1995-04-11 Solvay Enzymes, Inc. Purified enzyme concentrate and method of preparation
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
CN110082865B (zh) * 2011-02-17 2022-03-01 科姆斯科普连通比利时公司 用于将连接器附接到光纤上的便携设备

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2855698A1 (de) * 1978-12-22 1980-07-03 Green Cross Corp Verfahren zur herstellung eines urokinase mit einem molekulargewicht von 54 000 + 10 000 enthaltenden praeparats und seine verwendung als fibrinolytikum und thrombolytikum
JPS56106594A (en) * 1980-01-25 1981-08-24 Green Cross Corp:The Stabilizing method of plasminogen
DE3043857A1 (de) * 1980-11-21 1982-07-08 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii
CA1336585C (en) * 1985-04-16 1995-08-08 Kazuo Morimoto Method of stabilizing urokinase precursor and dry preparation containing said precursor

Also Published As

Publication number Publication date
DE3888404T2 (de) 1994-06-30
JPS63317084A (ja) 1988-12-26
EP0295940B1 (de) 1994-03-16
EP0295940A2 (de) 1988-12-21
EP0295940A3 (en) 1989-05-31
US4946785A (en) 1990-08-07
JP2545231B2 (ja) 1996-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee