DE3887875T2 - Verfahren zur vorbeugung einer von blutplättchen abhängigen gefässthrombose. - Google Patents

Verfahren zur vorbeugung einer von blutplättchen abhängigen gefässthrombose.

Info

Publication number
DE3887875T2
DE3887875T2 DE3887875T DE3887875T DE3887875T2 DE 3887875 T2 DE3887875 T2 DE 3887875T2 DE 3887875 T DE3887875 T DE 3887875T DE 3887875 T DE3887875 T DE 3887875T DE 3887875 T2 DE3887875 T2 DE 3887875T2
Authority
DE
Germany
Prior art keywords
dependent
platelets
vascular thrombosis
preventing vascular
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3887875T
Other languages
English (en)
Other versions
DE3887875D1 (de
Inventor
Laurence Harker
Stephen Hanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Application granted granted Critical
Publication of DE3887875D1 publication Critical patent/DE3887875D1/de
Publication of DE3887875T2 publication Critical patent/DE3887875T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE3887875T 1987-11-25 1988-11-23 Verfahren zur vorbeugung einer von blutplättchen abhängigen gefässthrombose. Expired - Lifetime DE3887875T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12517887A 1987-11-25 1987-11-25
US07/275,330 US4929602A (en) 1987-11-25 1988-11-22 Method of inhibiting platelet dependent arterial thrombosis
PCT/US1988/004210 WO1989005148A1 (en) 1987-11-25 1988-11-23 A method of inhibiting platelet dependent arterial thrombosis

Publications (2)

Publication Number Publication Date
DE3887875D1 DE3887875D1 (de) 1994-03-24
DE3887875T2 true DE3887875T2 (de) 1994-08-18

Family

ID=26823342

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887875T Expired - Lifetime DE3887875T2 (de) 1987-11-25 1988-11-23 Verfahren zur vorbeugung einer von blutplättchen abhängigen gefässthrombose.

Country Status (8)

Country Link
US (1) US4929602A (de)
EP (1) EP0343241B1 (de)
JP (1) JP2758953B2 (de)
AT (1) ATE101522T1 (de)
AU (1) AU599280B2 (de)
CA (1) CA1335075C (de)
DE (1) DE3887875T2 (de)
WO (1) WO1989005148A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
US5760015A (en) * 1988-01-19 1998-06-02 The Trustees Of The University Of Pennsylvania Cyclodextrin compounds and methods of making and use thereof
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
US5637575A (en) * 1988-01-19 1997-06-10 The Trustees Of The University Of Pennsylvania Methods of inhibiting restenosis
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
US5354770A (en) * 1989-02-27 1994-10-11 Daiichi Pharmaceutical Co., Ltd. Using imidazolyl tetrahydronaphthalene carboxylic acids to inhibit restenosis
US6146358A (en) * 1989-03-14 2000-11-14 Cordis Corporation Method and apparatus for delivery of therapeutic agent
US5242397A (en) * 1989-06-20 1993-09-07 Cedars-Sinai Medical Center Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9024129D0 (en) * 1990-11-06 1990-12-19 Thrombosis Research Trust Inhibitors and substrates of thrombin
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
US5990095A (en) 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
FR2695562B1 (fr) * 1992-09-11 1994-10-14 Synthelabo Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique.
US6387881B1 (en) 1992-09-19 2002-05-14 Trigen Ltd Inhibitors and substrates of thrombin
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
EP1826280A3 (de) 1992-09-25 2007-12-05 Boston Scientific Limited Therapeutische Konjugate zum Hemmen von glatten Gefäßmuskelzellen
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
ATE485825T1 (de) 1993-01-28 2010-11-15 Boston Scient Ltd Therapeutische inhibitoren der zellen der glatten gefässmuskulatur
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US6197789B1 (en) 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US5639726A (en) * 1994-09-30 1997-06-17 The Regents Of The University Of Michigan Peptide mediated enhancement of thrombolysis methods and compositions
US5643580A (en) * 1994-10-17 1997-07-01 Surface Genesis, Inc. Biocompatible coating, medical device using the same and methods
US5730698A (en) * 1995-05-09 1998-03-24 Fischell; Robert E. Balloon expandable temporary radioisotope stent system
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
ES2226120T3 (es) 1997-03-31 2005-03-16 Boston Scientific Limited Inhibidor terapeutico de celulas del musculo liso vascular.
AU9016898A (en) 1997-08-07 1999-03-01 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Methods and compositions for treatment of restenosis
US6187038B1 (en) 1998-04-08 2001-02-13 Sulzer Carbomedics Inc. Small bore biologic graft with therapeutic delivery system
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US431890A (en) * 1890-07-08 Tool for extracting drill-rods
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel

Also Published As

Publication number Publication date
ATE101522T1 (de) 1994-03-15
EP0343241B1 (de) 1994-02-16
US4929602A (en) 1990-05-29
EP0343241A4 (en) 1991-07-31
AU3286489A (en) 1989-07-05
WO1989005148A1 (en) 1989-06-15
CA1335075C (en) 1995-04-04
JP2758953B2 (ja) 1998-05-28
DE3887875D1 (de) 1994-03-24
JPH04501848A (ja) 1992-04-02
AU599280B2 (en) 1990-07-12
EP0343241A1 (de) 1989-11-29

Similar Documents

Publication Publication Date Title
DE3887875T2 (de) Verfahren zur vorbeugung einer von blutplättchen abhängigen gefässthrombose.
DE59101695D1 (de) Verfahren zur Erzeugung von niederen Olefinen.
DE3777417D1 (de) Verfahren zur kryokonservierung von herzklappen.
DE69019753D1 (de) Verfahren zur verwendung von gashilfe während des giessens von kunststoffgegenständen.
DE69100197T2 (de) Verfahren zur Verhinderung von Hydraten.
DE59404520D1 (de) Verfahren zur Hydroformylierung von Butadien-1.3
DE59402292D1 (de) Verfahren zur Herstellung von 1,3,5-Triazinen
DE68921582D1 (de) Verfahren zur Herstellung von funktionellen Isothiocyanatometallkomplexen.
DE69202115T2 (de) Verfahren zur Darstellung von 1,2-Naphtho-Chinondiazido-5-Sulfonylchlorid.
DE69002330D1 (de) Verfahren und befestigungsweise zur verbindung von karosserieteilen.
DE59006645D1 (de) Verfahren zur kontinuierlichen herstellung von 3,3'-dichlor-benzidin-dihidrochlorid.
DE69207648D1 (de) Verfahren zur Herstellung von Pfropfcopolymeren
DE59309002D1 (de) Verfahren zur Herstellung von 6-Chlor-(6H)-dibenz-(c,e)(1,2)-oxaphosphorin
DE68905393D1 (de) Verfahren zur oxydierung von ungesaettigten aromatischen verbindungen.
DE58901165D1 (de) Verfahren zur herstellung von 2,4-dihydroxybenzoesaeure.
DE68923159D1 (de) Verfahren zur Herstellung von 1,4-Dihydropyridin-Derivaten.
DE69214974D1 (de) Verfahren zur Herstellung von 9-Amino-1,2,3,4-tetrahydroacridin
DE59103040D1 (de) Verfahren zur Herstellung von symmetrischen 2,2'-Methylen-bis-benztriazolylphenolen.
DE69205870D1 (de) Verfahren zur selektiven Reduktion von 4-Halogenatom in 2,4-Dihaloaniline.
DE69104648D1 (de) Verfahren zur Herstellung von Ketonen.
DE59300178D1 (de) Verfahren zur Herstellung von 2,5-disubstituierten Pyridinen.
DE59104842D1 (de) Verfahren zur Herstellung von 2,3-Dibrompropionylchlorid.
DE68909118D1 (de) Verfahren zur Ausscheidung von 2,6-Dimethylnaphthalin.
DE3879789T2 (de) Verfahren zur Herstellung von 2,6-Dichlorpyridin.
DE59201646D1 (de) Verfahren zur Herstellung von Dihydroxyaceton.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition