DE3885959D1 - Cyclosporine. - Google Patents

Cyclosporine.

Info

Publication number
DE3885959D1
DE3885959D1 DE88306697T DE3885959T DE3885959D1 DE 3885959 D1 DE3885959 D1 DE 3885959D1 DE 88306697 T DE88306697 T DE 88306697T DE 3885959 T DE3885959 T DE 3885959T DE 3885959 D1 DE3885959 D1 DE 3885959D1
Authority
DE
Germany
Prior art keywords
amino
group
methylamino
mercapto
acid residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88306697T
Other languages
English (en)
Other versions
DE3885959T2 (de
Inventor
Ian James Galpin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Publication of DE3885959D1 publication Critical patent/DE3885959D1/de
Application granted granted Critical
Publication of DE3885959T2 publication Critical patent/DE3885959T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE88306697T 1987-07-22 1988-07-21 Cyclosporine. Expired - Fee Related DE3885959T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878717300A GB8717300D0 (en) 1987-07-22 1987-07-22 Cyclosporins

Publications (2)

Publication Number Publication Date
DE3885959D1 true DE3885959D1 (de) 1994-01-13
DE3885959T2 DE3885959T2 (de) 1994-03-24

Family

ID=10621087

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88306697T Expired - Fee Related DE3885959T2 (de) 1987-07-22 1988-07-21 Cyclosporine.

Country Status (6)

Country Link
US (1) US5079341A (de)
EP (1) EP0300785B1 (de)
JP (1) JPH01151600A (de)
AT (1) ATE97916T1 (de)
DE (1) DE3885959T2 (de)
GB (2) GB8717300D0 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH679119A5 (de) * 1988-05-13 1991-12-31 Sandoz Ag
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
EP0484281B2 (de) * 1990-11-02 2000-11-22 Novartis AG Zyklosporine
US5362629A (en) * 1991-08-05 1994-11-08 President And Fellows Of Harvard College Detection of immunosuppressants
WO1993017701A1 (en) * 1992-03-12 1993-09-16 The Administrators Of The Tulane Educational Fund Endothelin receptor-binding peptides
ATE152734T1 (de) * 1992-05-30 1997-05-15 Sikiric Predrag Bpc-peptide, deren herstellung und verwendung
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DK0991660T3 (da) 1997-10-08 2006-02-13 Isotechnika Inc Deuterede og udeuterede cyclosporinanaloger og deres anvendelse som immunmodulerende midler
US6790935B1 (en) 1999-02-05 2004-09-14 Debiopharm S.A. Cyclosporin derivatives and method for the production of said derivatives
PL210841B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny izomerów (E) i (Z) ISATX247
NZ594755A (en) 2009-01-30 2013-12-20 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
EP3461835A1 (de) 2010-12-15 2019-04-03 ContraVir Pharmaceuticals, Inc. An den aminosäuren 1 und 3 modifizierte cyclosporin-analog-moleküle
WO2012145427A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
AU2014311346A1 (en) 2013-08-26 2016-03-17 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455859C2 (de) * 1973-12-06 1983-12-15 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin

Also Published As

Publication number Publication date
GB2208294A (en) 1989-03-22
EP0300785B1 (de) 1993-12-01
GB8817434D0 (en) 1988-08-24
GB2208294B (en) 1991-04-24
GB8717300D0 (en) 1987-08-26
DE3885959T2 (de) 1994-03-24
EP0300785A2 (de) 1989-01-25
JPH01151600A (ja) 1989-06-14
EP0300785A3 (en) 1990-05-23
ATE97916T1 (de) 1993-12-15
US5079341A (en) 1992-01-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee