DE3884672D1 - Ein synthetisches Nonapeptid zur Verwendung als Adjuvant. - Google Patents

Ein synthetisches Nonapeptid zur Verwendung als Adjuvant.

Info

Publication number
DE3884672D1
DE3884672D1 DE88830056T DE3884672T DE3884672D1 DE 3884672 D1 DE3884672 D1 DE 3884672D1 DE 88830056 T DE88830056 T DE 88830056T DE 3884672 T DE3884672 T DE 3884672T DE 3884672 D1 DE3884672 D1 DE 3884672D1
Authority
DE
Germany
Prior art keywords
adjuvant
thymo
synthetic nonapeptide
peptide
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88830056T
Other languages
English (en)
Other versions
DE3884672T2 (de
Inventor
Luciano Nencioni
Guido Antoni
Diana Boraschi
Aldo Tagliabue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo SpA filed Critical Sclavo SpA
Application granted granted Critical
Publication of DE3884672D1 publication Critical patent/DE3884672D1/de
Publication of DE3884672T2 publication Critical patent/DE3884672T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE88830056T 1987-02-20 1988-02-16 Ein synthetisches Nonapeptid zur Verwendung als Adjuvant. Expired - Fee Related DE3884672T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19434/87A IT1217314B (it) 1987-02-20 1987-02-20 Nonapeptide sintetico ad attivita'adiuvante capace di potenziare in vivo la risposta anticorporale

Publications (2)

Publication Number Publication Date
DE3884672D1 true DE3884672D1 (de) 1993-11-11
DE3884672T2 DE3884672T2 (de) 1994-04-28

Family

ID=11157912

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88830056T Expired - Fee Related DE3884672T2 (de) 1987-02-20 1988-02-16 Ein synthetisches Nonapeptid zur Verwendung als Adjuvant.

Country Status (7)

Country Link
US (1) US5206014A (de)
EP (1) EP0293333B1 (de)
JP (1) JPS63301829A (de)
AT (1) ATE95422T1 (de)
DE (1) DE3884672T2 (de)
ES (1) ES2059562T3 (de)
IT (1) IT1217314B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3392860B2 (ja) * 1989-05-25 2003-03-31 スローン−ケツテリング・インステイテユート・フオー・キヤンサー・リサーチ スフィンゴ糖脂質に対する免疫応答を誘導する抗イディオタイプ抗体及びその使用
US6432402B1 (en) 1989-05-25 2002-08-13 Sloan-Kettering Institute For Cancer Research Anti-idiotypic antibody which induces an immune response against a glycosphingolipid and use thereof
IT1262898B (it) * 1992-03-23 1996-07-22 Antigeni ricombinanti proteici ad aumentata immunogenicita' contenenti il peptide rappresentato dalla sequenza vqgeesndk
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
US6656462B2 (en) 1999-12-03 2003-12-02 Richard S. Dondero Interleukin-1 muteins useful as vaccine adjuvants

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283328A (en) * 1979-10-01 1981-08-11 Research Corporation Preparation of dehydropeptides
EP0033384B1 (de) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunstimulierender Wirkung, und Thymosin-alpha-1-Fragmente
JPS57197223A (en) * 1981-05-27 1982-12-03 Eisai Co Ltd Immunoenhancing agent containing ricin b chain
DE3224379A1 (de) * 1982-06-30 1984-01-12 Hoechst Ag, 6230 Frankfurt Nonapeptid mit immunstimulierender wirkung, verfahren zu dessen herstellung und dessen verwendung
DE3230151A1 (de) * 1982-08-13 1984-02-16 Hoechst Ag, 6230 Frankfurt Neues polypeptid mit wirkung auf das immunsystem, verfahren zu seiner isolierung und reinigung, seine verwendung, dieses enthaltende mittel sowie seine spaltprodukte, deren verwendung und diese enthaltende mittel
US4845079A (en) * 1985-01-23 1989-07-04 Luly Jay R Peptidylaminodiols
IT1188550B (it) * 1986-02-07 1988-01-14 Sclavo Spa Peptide sintetico ad attivita' interleukina 1 umana

Also Published As

Publication number Publication date
DE3884672T2 (de) 1994-04-28
JPS63301829A (ja) 1988-12-08
IT8719434A0 (it) 1987-02-20
IT1217314B (it) 1990-03-22
EP0293333A2 (de) 1988-11-30
ATE95422T1 (de) 1993-10-15
EP0293333B1 (de) 1993-10-06
US5206014A (en) 1993-04-27
EP0293333A3 (en) 1990-09-19
ES2059562T3 (es) 1994-11-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee