DE3884551D1 - Radioaktive benzodiazepinderivate und verfahren zu ihrer herstellung. - Google Patents

Radioaktive benzodiazepinderivate und verfahren zu ihrer herstellung.

Info

Publication number
DE3884551D1
DE3884551D1 DE88309717T DE3884551T DE3884551D1 DE 3884551 D1 DE3884551 D1 DE 3884551D1 DE 88309717 T DE88309717 T DE 88309717T DE 3884551 T DE3884551 T DE 3884551T DE 3884551 D1 DE3884551 D1 DE 3884551D1
Authority
DE
Germany
Prior art keywords
production
benzodiazepine derivatives
radioactive benzodiazepine
radioactive
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88309717T
Other languages
English (en)
Other versions
DE3884551T2 (de
Inventor
Iwao Nakatsuka
Masami Okuno
Kunio Shiba
Akira Yoshitake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Application granted granted Critical
Publication of DE3884551D1 publication Critical patent/DE3884551D1/de
Publication of DE3884551T2 publication Critical patent/DE3884551T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE88309717T 1987-10-19 1988-10-17 Radioaktive Benzodiazepinderivate und Verfahren zu ihrer Herstellung. Expired - Fee Related DE3884551T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62263543A JPH0780858B2 (ja) 1987-10-19 1987-10-19 放射性ベンゾジアゼピン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
DE3884551D1 true DE3884551D1 (de) 1993-11-04
DE3884551T2 DE3884551T2 (de) 1994-02-17

Family

ID=17391000

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88309717T Expired - Fee Related DE3884551T2 (de) 1987-10-19 1988-10-17 Radioaktive Benzodiazepinderivate und Verfahren zu ihrer Herstellung.

Country Status (7)

Country Link
US (1) US4885152A (de)
EP (1) EP0313291B1 (de)
JP (1) JPH0780858B2 (de)
KR (1) KR960006732B1 (de)
AU (1) AU610254B2 (de)
CA (1) CA1304364C (de)
DE (1) DE3884551T2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1318668C (en) * 1988-08-05 1993-06-01 Heinz Carmann Radioiodine benzodiazepine derivatives
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
JPH04135825U (ja) * 1991-06-12 1992-12-17 市光工業株式会社 ラジエータグリル
JPH0520914U (ja) * 1991-08-30 1993-03-19 市光工業株式会社 ラジエータグリル
JP2586411B2 (ja) * 1995-03-03 1997-02-26 住友化学工業株式会社 放射性ベンゾジアゼピン誘導体およびその製造法
US6171578B1 (en) 1999-04-14 2001-01-09 Diatide, Inc. Benzodiazepine derivatives for imaging thrombi

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT314541B (de) * 1970-10-19 1974-04-10 Sumitomo Chemical Co Verfahren zur Herstellung von neuen Benzodiazepinen und ihren Salzen
JPS50116485A (de) * 1974-02-27 1975-09-11
US4083948A (en) * 1977-04-04 1978-04-11 Hoffmann-La Roche, Inc. Benzodiazepine radioimmunoassay using I125-label
FR2415303A1 (fr) * 1978-05-31 1979-08-17 Ferrosan As Procede pour la determination de la concentration de benzodiazepines dans un fluide de l'organisme
US4606908A (en) * 1983-10-04 1986-08-19 Washington Research Foundation Methods and compositions for plasma and organ imaging
BE899739A (nl) * 1984-05-24 1984-11-26 Univ Bruxelles Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.

Also Published As

Publication number Publication date
AU2335288A (en) 1989-04-20
DE3884551T2 (de) 1994-02-17
CA1304364C (en) 1992-06-30
US4885152A (en) 1989-12-05
JPH01106875A (ja) 1989-04-24
KR890006598A (ko) 1989-06-14
EP0313291B1 (de) 1993-09-29
KR960006732B1 (ko) 1996-05-23
JPH0780858B2 (ja) 1995-08-30
AU610254B2 (en) 1991-05-16
EP0313291A1 (de) 1989-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SUMITOMO CHEMICAL CO. LTD., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee