DE3877036T2 - Biologisch aktive verbindungen. - Google Patents

Biologisch aktive verbindungen.

Info

Publication number
DE3877036T2
DE3877036T2 DE8888303064T DE3877036T DE3877036T2 DE 3877036 T2 DE3877036 T2 DE 3877036T2 DE 8888303064 T DE8888303064 T DE 8888303064T DE 3877036 T DE3877036 T DE 3877036T DE 3877036 T2 DE3877036 T2 DE 3877036T2
Authority
DE
Germany
Prior art keywords
group
compound according
pyrid
residue
butanoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888303064T
Other languages
German (de)
English (en)
Other versions
DE3877036D1 (de
Inventor
David Gwyn Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Application granted granted Critical
Publication of DE3877036D1 publication Critical patent/DE3877036D1/de
Publication of DE3877036T2 publication Critical patent/DE3877036T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE8888303064T 1987-04-07 1988-04-06 Biologisch aktive verbindungen. Expired - Fee Related DE3877036T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878708233A GB8708233D0 (en) 1987-04-07 1987-04-07 Pharmaceutically active compounds

Publications (2)

Publication Number Publication Date
DE3877036D1 DE3877036D1 (de) 1993-02-11
DE3877036T2 true DE3877036T2 (de) 1993-05-19

Family

ID=10615351

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888303064T Expired - Fee Related DE3877036T2 (de) 1987-04-07 1988-04-06 Biologisch aktive verbindungen.

Country Status (13)

Country Link
US (1) US4902698A (https=)
EP (1) EP0287270B1 (https=)
JP (1) JPS63267760A (https=)
AT (1) ATE84028T1 (https=)
AU (1) AU598654B2 (https=)
CA (1) CA1330343C (https=)
DE (1) DE3877036T2 (https=)
DK (1) DK189988A (https=)
ES (1) ES2052711T3 (https=)
GB (1) GB8708233D0 (https=)
GR (1) GR3007089T3 (https=)
PT (1) PT87162B (https=)
ZA (1) ZA882374B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3932403A1 (de) * 1989-05-12 1991-04-11 Thomae Gmbh Dr K Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5153214A (en) * 1989-06-28 1992-10-06 Ciba-Geigy Corporation Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
US5025025A (en) * 1989-06-28 1991-06-18 Ciba-Geigy Corporation (Arylsulfonamido- and pyridyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
DE4037112A1 (de) * 1990-11-22 1992-05-27 Thomae Gmbh Dr K Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5286736A (en) * 1990-11-22 1994-02-15 Dr. Karl Thomae Gmbh Pyridyl compounds and pharmaceutical compositions containing these compounds
WO1996019455A1 (en) * 1994-12-20 1996-06-27 F. Hoffmann-La Roche Ag Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists
US6653331B2 (en) * 1996-07-03 2003-11-25 Pharmacia & Upjohn Company Targeted drug delivery using sulfonamide derivatives
US6048861A (en) * 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122313C (https=) * 1963-07-11
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4210759A (en) * 1978-05-24 1980-07-01 Henkel Corporation Benzene sulfonamido pyridine derivatives
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3139970A1 (de) * 1981-10-08 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0194548A3 (de) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3535167A1 (de) * 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions
GB8528398D0 (en) * 1985-11-19 1985-12-24 Glaxo Group Ltd Chemical compounds
DE3610643A1 (de) * 1986-03-29 1987-10-01 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeure-derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
IL83230A (en) * 1986-08-06 1992-06-21 Tanabe Seiyaku Co Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3629929A1 (de) * 1986-09-03 1988-03-10 Thomae Gmbh Dr K Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PT87162B (pt) 1992-07-31
AU598654B2 (en) 1990-06-28
DK189988A (da) 1988-10-08
EP0287270B1 (en) 1992-12-30
EP0287270A1 (en) 1988-10-19
PT87162A (pt) 1988-05-01
ES2052711T3 (es) 1994-07-16
DK189988D0 (da) 1988-04-07
US4902698A (en) 1990-02-20
GR3007089T3 (https=) 1993-07-30
JPS63267760A (ja) 1988-11-04
ATE84028T1 (de) 1993-01-15
DE3877036D1 (de) 1993-02-11
ZA882374B (en) 1989-03-29
AU1406888A (en) 1988-10-13
CA1330343C (en) 1994-06-21
GB8708233D0 (en) 1987-05-13

Similar Documents

Publication Publication Date Title
EP0908456B1 (de) Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE60017582T2 (de) Tricyclische derivate der pyrazolcarbonsäure, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
CH660731A5 (de) Aminderivate und deren salze.
DD270304A5 (de) Verfahren zur herstellung von 5-alkylbenzimidazolen
EP0041215B1 (de) Imidazoazolalkensäureamide, neue Zwischenprodukte zu ihrer Herstellung, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE69312567T2 (de) 2-Formylpyridin-Thiosemicarbazonderivate, ihre Herstellung und ihre Verwendung als Antitumor Mittel
DE3877036T2 (de) Biologisch aktive verbindungen.
DE3850308T2 (de) Tetrahydroisochinolin-2-yl-Derivate als Thromboxan A2-Antagonisten.
DE69112074T2 (de) Disubstituierte arylverbindungen welche eine selektive leukotrien-b4 antagonistische aktivität aufweisen.
DE3830060A1 (de) 2-phenylbenzimidazole - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3306146A1 (de) Pyridin-derivate und ihre verwendung als arzneimittel
CA1222249A (en) Bactericidal agents based on quinolonecarboxylic acids
DE1620016C3 (de) 3-{Piperazinoalkyl)-pyrazole und Verfahren zu ihrer Herstellung
DE3871705T2 (de) 2,4-disubstituierte tetrahydrofuranderivate.
DD238790A5 (de) Verfahren zur herstellung von 3-amino carbonylmethoxy-5-phenylpyrazol-verbindungen
DE3889208T2 (de) Thioformamid-Derivate.
DE3804346A1 (de) Tert.-butylphenyl-pyridyl-amide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE68924416T2 (de) Carboximidamid-Derivate.
DE2656227C2 (de) Basisch alkylierte Diphenyldisulfid-2,2'-biscarbonsäureamide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
EP0581797B1 (de) Neue thiophen-2-carbonsäurederivate und verfahren zu deren herstellung
DE3217206C2 (https=)
DE3710254A1 (de) Antiulcusmittel
DE2319281A1 (de) Diuretisches und antihypertensives mittel
DE68921175T2 (de) Benzopyrantyp-Verbindungen.
DE69422038T2 (de) Benzopyranderivate

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee