DE3867822D1 - Zwischenprodukte und verfahren fuer 6-carboxy-hmg-coa-reduktase-inhibitoren. - Google Patents

Zwischenprodukte und verfahren fuer 6-carboxy-hmg-coa-reduktase-inhibitoren.

Info

Publication number
DE3867822D1
DE3867822D1 DE8888202761T DE3867822T DE3867822D1 DE 3867822 D1 DE3867822 D1 DE 3867822D1 DE 8888202761 T DE8888202761 T DE 8888202761T DE 3867822 T DE3867822 T DE 3867822T DE 3867822 D1 DE3867822 D1 DE 3867822D1
Authority
DE
Germany
Prior art keywords
hmg
coa
carboxy
reductase inhibitors
intermediate products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888202761T
Other languages
English (en)
Inventor
Ta Jyh Lee
William F Hoffman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3867822D1 publication Critical patent/DE3867822D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
DE8888202761T 1987-12-11 1988-12-02 Zwischenprodukte und verfahren fuer 6-carboxy-hmg-coa-reduktase-inhibitoren. Expired - Fee Related DE3867822D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/131,695 US4841074A (en) 1987-12-11 1987-12-11 Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors

Publications (1)

Publication Number Publication Date
DE3867822D1 true DE3867822D1 (de) 1992-02-27

Family

ID=22450612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888202761T Expired - Fee Related DE3867822D1 (de) 1987-12-11 1988-12-02 Zwischenprodukte und verfahren fuer 6-carboxy-hmg-coa-reduktase-inhibitoren.

Country Status (5)

Country Link
US (1) US4841074A (de)
EP (1) EP0320052B1 (de)
JP (1) JPH01265084A (de)
CA (1) CA1307264C (de)
DE (1) DE3867822D1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4940727A (en) * 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US5116870A (en) * 1986-06-23 1992-05-26 Merck & Co., Inc. HMG-CoA reductase inhibitors
USRE36481E (en) * 1986-06-23 2000-01-04 Merck & Co., Inc. HMG-CoA reductase inhibitors
US5173487A (en) * 1989-11-13 1992-12-22 E. R. Squibb & Sons, Inc. Mevinic acid derivatives
WO2016161085A1 (en) 2015-04-01 2016-10-06 Cedars-Sinai Medical Center Anti-methanogenic lovastatin analogs or derivatives and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS5815968A (ja) * 1981-07-21 1983-01-29 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製法
JPS5855443A (ja) * 1981-09-25 1983-04-01 Sankyo Co Ltd オクタヒドロナフタリン誘導体およびその製造法
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4584389A (en) * 1983-10-11 1986-04-22 Merck & Co., Inc. Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
US4738982A (en) * 1986-04-28 1988-04-19 Merck & Co., Inc. HMG-CoA reductase inhibitors
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4719229A (en) * 1987-05-13 1988-01-12 Merck & Co., Inc. Antihypercholesterolemic agents
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors

Also Published As

Publication number Publication date
EP0320052A2 (de) 1989-06-14
CA1307264C (en) 1992-09-08
EP0320052B1 (de) 1992-01-15
US4841074A (en) 1989-06-20
EP0320052A3 (en) 1989-08-16
JPH01265084A (ja) 1989-10-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee